A5019109535- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Prostate Cancer Treatment and Research
- Electrowetting and Microfluidic Technologies
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Electrostatics and Colloid Interactions
- Electrohydrodynamics and Fluid Dynamics
- Nanopore and Nanochannel Transport Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Spectroscopy and Laser Applications
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Atmospheric and Environmental Gas Dynamics
- Sports Performance and Training
- Pharmacological Effects and Toxicity Studies
- Platelet Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Laser Design and Applications
- Mass Spectrometry Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Chronic Lymphocytic Leukemia Research
Cornell University
2014-2025
Gilead Sciences (United States)
2015-2023
The University of Texas MD Anderson Cancer Center
2023
Weill Cornell Medicine
2016-2022
Gossamer Bio (United States)
2022
Columbia University
2022
Brookhaven College
2020
Sibley Memorial Hospital
2008-2019
Ithaca College
2010-2018
Sidney Kimmel Comprehensive Cancer Center
2017
Geometrically enhanced differential immunocapture (GEDI) and an antibody for prostate-specific membrane antigen (PSMA) are used high-efficiency high-purity capture of prostate circulating tumor cells from peripheral whole blood samples castrate-resistant cancer patients.
Recent determinations of the temperature dependence acetone fluorescence have permitted application planar laser-induced imaging, which was already popular for mapping concentration, to measurement temperature. With a view toward developing temperature-imaging diagnostics, we present atmospheric-pressure and absorption results acquired with excitation at eight wavelengths across feature temperatures from 300 1000 K. Modeling yield is shown be useful in explaining both these variation...
The objectives of the study were to evaluate effects pregnancy on CYP3A and P-glycoprotein (P-gp) activities, as measured by disposition midazolam digoxin, respectively. Thirteen women received digoxin (0.25 mg p.o.) (2 in random order, separated 1-2 weeks at 28-32 gestation, same order was repeated 6-10 postpartum. Plasma urine concentrations determined liquid chromatography-mass spectrometry analyzed noncompartmental methods. Midazolam CL/F(unbound) (593 +/- 237 l/min vs. 345 103 l/min; P...
Cancer metastasis accounts for the majority of cancer-related deaths owing to poor response anticancer therapies. Molecular understanding metastasis-associated drug resistance remains elusive due scarcity available tumor tissue. Isolation circulating cells (CTCs) from peripheral blood patients has emerged as a valid alternative source tissue that can be subjected molecular characterization. However, issues with low purity and sensitivity have impeded adoption clinical practice. Here we...
Abstract This paper combines new experimental data for electrokinetic characterization of hydrophobic polymers with a detailed discussion the putative origins charge at water‐hydrophobe interfaces. Complexities in determining origin are discussed context design and modeling challenges actuation microfluidic devices aqueous working fluids. Measurements interfacial complicated by slip water structuring phenomena (see Part 2, this issue). Despite these complexities, it is shown that (i) several...
We show that rubidium vapor can be produced within the core of a photonic band-gap fiber yielding an optical depth in excess 2,000. Our technique for producing is based on coating inner walls with organosilane and using light-induced atomic desorption to release Rb atoms into core. As initial demonstration potential this system supporting ultralow-level nonlinear interactions, we perform electromagnetically induced transparency control-field powers nanowatt regime, which represents more than...
Methods for seeding high-viability (>85%) three-dimensional (3D) alginate–chondrocyte hydrogel scaffolds are presented that employ photocrosslinking of methacrylate-modified alginate with the photoinitiator VA-086. Comparison results from several other photoinitiators, including Irgacure 2959, highlights role solvent, ultraviolet exposure, and cytotoxicity on process viability bovine chondrocytes in two-dimensional culture. The radicals generated VA-086 photodissociation shown to be...
This paper examined the influence of different statistical modeling techniques on interpretation peak ˙VO2 data in groups prepubertal, circumpubertal, and adult males (group 1M, N = 29; group 2M, 26; 3M, 8) females 1F,N 33; 2F, 34; 3F, 16). Conventional comparisons simple per-body-mass ratio(ml·kg-1·min-1) revealed no significant differences between three male (P < 0.05). In females, a decline 2F 3F was observed (P< Both linear log-linear (allometric) models increases across all for adjusted...
We present the development of a continuous-flow, "dielectrophoretic spectrometer" based on insulative DEP techniques and three-dimensional geometric design. Hot-embossed thermoplastic devices allow for high-throughput analysis control electric fields via ridged microstructures patterned in high width-to-depth aspect ratio (250:1) channel. manipulate particles with dc-biased, ac generate continuous-output streams transverse outlet position specified by linear nonlinear particle mobilities....
Electronic polarization effects play an important role in the interactions of charged species biologically relevant aqueous solutions, such as those involving salt ions, proteins, nucleic acids, or phospholipid membranes. Explicit inclusion electronic molecular modeling is tedious both from point view force field parametrization and actual performance simulations. Therefore, vast majority biomolecular simulations performed using nonpolarizable fields, which can lead to artifacts dramatically...
Optimization of pancreatic CTC immunocapture and phenotyping in a microfluidic device.
•Sofosbuvir/velpatasvir (SOF/VEL) is approved for patients with HCV infection.•There no dosing recommendation SOF-based regimens HCV-infected on dialysis.•We evaluated SOF/VEL 12 weeks in end-stage renal disease dialysis.•SOF/VEL was safe and well tolerated, a cure rate of 95% our study. Background & AimsAlthough off-label use sofosbuvir-containing occurs regularly hepatitis C virus (HCV) infection undergoing dialysis severe impairment or (ESRD), these are not licensed this indication, there...
Children with chronic hepatitis C virus infection have limited treatment options. We evaluated the all-oral combination of sofosbuvir and ribavirin in adolescents aged 12-17 genotype 2 or 3 (ClinicalTrials.gov NCT02175758). Fifty-two patients received 400 mg once daily weight-based twice for 12 (genotype 2) 24 3) weeks. The pharmacokinetics its metabolite GS-331007 were by intensive plasma sampling at day 7 first 10 enrolled sparse all throughout treatment. primary efficacy endpoint was...
Biomarkers aiding treatment optimization in metastatic castration-resistant prostate cancer (mCRPC) are scarce. The presence or absence of androgen receptor (AR) splice variants, AR-V7 and AR
Significance Statement Findings in animal models of diabetic kidney disease identified selonsertib, a selective inhibitor apoptosis signal–regulating kinase 1 (ASK1), as potential therapeutic agent. In randomized, dose-ranging, placebo-controlled phase 2 trial evaluating selonsertib’s safety and efficacy patients with moderate-to-advanced disease, the authors found that selonsertib appeared safe, no dose-dependent adverse effects over 48 weeks, including for 18-mg daily dose thought to...
Laser-patterning of nanoporous membranes at the junction a cross channel in microchip is used to integrate protein concentration with an electrokinetic injection scheme. Upon application voltage, linear electrophoretic charged proteins achieved membrane surface because buffer ions can easily pass through while larger than molecular weight cutoff (>5700) are retained. Simple systems be used, and results constitute outward evidence that uniformity ion maintained throughout process. Local...