A5005839481- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Vaccine Coverage and Hesitancy
- Gallbladder and Bile Duct Disorders
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Transplantation: Methods and Outcomes
- Adolescent and Pediatric Healthcare
- Respiratory viral infections research
- Hematopoietic Stem Cell Transplantation
- Animal Virus Infections Studies
- Mobile Health and mHealth Applications
- Neonatal Health and Biochemistry
- COVID-19 Clinical Research Studies
- Drug Transport and Resistance Mechanisms
- COVID-19 Impact on Reproduction
- Liver Diseases and Immunity
- Childhood Cancer Survivors' Quality of Life
University of Colorado Denver
2015-2025
Children's Hospital Colorado
2015-2025
University of Colorado Anschutz Medical Campus
2024-2025
E Ink (South Korea)
2022
Outcomes Research Consortium
2017-2022
Lurie Children's Hospital
2013
Northwestern University
2013
Boston Children's Hospital
2013
Inova Fairfax Hospital
1993
Care Resource
1993
Cholestatic jaundice is a common presenting feature of neonatal hepatobiliary and metabolic dysfunction. Any infant who remains jaundiced beyond age 2 to 3 weeks should have the serum bilirubin level fractionated into conjugated (direct) unconjugated (indirect) portion. Conjugated hyperbilirubinemia never physiologic or normal. The differential diagnosis cholestasis extensive, step-wise approach based on initial history physical examination useful rapidly identify underlying etiology. Early...
Pediatric transplant recipients are at risk for vaccine-preventable infections owing to immunosuppression, suboptimal response vaccines before and after transplant, potential underimmunization if occurred early in life. However, the incidence burden of illness from this population is unknown.To evaluate pediatric solid organ number hospitalizations first 5 years determine associated morbidity, mortality, costs.A retrospective cohort study January 1, 2004, December 31, 2011, with follow-up...
Abstract Nationally, immunization delivery has decreased significantly during the coronavirus disease 2019 (COVID-19) pandemic. Internationally, >60 national vaccine programs have been disrupted or suspended. As a result of these declines, global community is at risk for resurgence in vaccine-preventable infections including measles, pertussis, and polio—all highly contagious diseases that significant morbidity mortality children. Measles outbreaks already occurred many countries...
Importance Live vaccines (measles-mumps-rubella [MMR] and varicella-zoster virus [VZV]) have not been recommended after solid organ transplant due to concern for inciting vaccine strain infection in an immunocompromised host. However, the rates of measles, mumps, varicella are rising nationally internationally, leaving susceptible children at risk life-threating conditions. Objective To determine safety immunogenicity live pediatric liver kidney recipients. Design, Setting, Participants This...
ABSTRACT Background Despite the existence of institutional protocols, liver transplant centers often have variability in early immunosuppression practices. We aimed to measure within‐center after pediatric (LT) and examine its association with one‐year outcomes. Methods analyzed LTs from 2013 2018 United Network for Organ Sharing registry, data aggregated by center. categorized induction regimen as corticosteroids only vs. T‐cell depleting antibody non‐T‐cell antibody. Primary exposures were...
ABSTRACT Introduction Biliary atresia (BA) is the most common indication for liver transplantation (LT) in children. We aimed to identify risk factors associated with survival young patients BA modern era. Methods performed a retrospective analysis of aged < 2 years who received their first isolated LT available data from United Network Organ Sharing database (01/2013–12/2022). Factors included multivariable Cox regression were graft type, race/ethnicity, insurance status, laboratory...
This cohort study assesses the protection provided by live attenuated viral vaccines among a pediatric population of solid organ transplant recipients 1 year after vaccination.
ABSTRACT Background Biliary strictures (BS) remain a challenge in pediatric liver transplant (LT). Achievement of the “Optimal Outcome” (OBO), stricture resolution without recurrence or surgery is goal. We analyzed cost associated with different management. Methods Society Pediatric LT (SPLIT) data were matched Health Information System (PHIS) by dates birth and transplant, center sex. SPLIT used to identify recipients (2011–2016) BS. Procedure admissions costs from PHIS inflation‐adjusted...
A leading theory regarding the pathogenesis of biliary atresia (BA) is that bile duct injury initiated by a virus infection, followed an autoimmune response targeting ducts. In experimental models diseases, B cells have been shown to play important role. The aim this study was determine role in development obstruction Rhesus rotavirus (RRV)-induced mouse model BA. Wild-type (WT) and cell-deficient (Ig-α(-/-)) mice received RRV shortly after birth. Ig-α(-/-) RRV-infected had significantly...