A5025711687- Respiratory viral infections research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Cytomegalovirus and herpesvirus research
- Hepatitis Viruses Studies and Epidemiology
- Health Sciences Research and Education
- Homelessness and Social Issues
- Bacterial Infections and Vaccines
- Ethics in Clinical Research
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Viral Infections and Immunology Research
- Clostridium difficile and Clostridium perfringens research
- Immunodeficiency and Autoimmune Disorders
- Disaster Response and Management
- Ocular Diseases and Behçet’s Syndrome
- Hepatitis B Virus Studies
- Meta-analysis and systematic reviews
- Antimicrobial Resistance in Staphylococcus
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Neonatal Health and Biochemistry
- Innovations in Medical Education
University of Colorado Anschutz Medical Campus
2021-2024
University of Colorado Denver
2014-2023
Accreditation Council for Graduate Medical Education
2023
Children's Hospital Colorado
2012-2022
RELX Group (United States)
2021
Johns Hopkins University
2001
Energy Center of Wisconsin
2001
Highland Community College - Illinois
2001
University of Wisconsin–Madison
2001
Pediatric transplant recipients are at risk for vaccine-preventable infections owing to immunosuppression, suboptimal response vaccines before and after transplant, potential underimmunization if occurred early in life. However, the incidence burden of illness from this population is unknown.To evaluate pediatric solid organ number hospitalizations first 5 years determine associated morbidity, mortality, costs.A retrospective cohort study January 1, 2004, December 31, 2011, with follow-up...
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are generally asymptomatic or have mild symptoms low rates of hospitalization (<2%) and death (<0.03%).1 After initial infection, some children, including those who experienced disease, develop other postacute manifestations COVID, multisystem inflammatory in children (MIS-C, not discussed this statement) sequelae SARS-CoV-2 infection. The latter post-COVID condition may be known as long long-haul COVID-19,...
Background Limited data are available describing the clinical presentation and risk factors for admission to intensive care unit children with 2009 H1N1 infection. Methods We conducted a retrospective chart review of all hospitalized influenza A (H1N1) 2008–09 seasonal at The Children's Hospital, Denver, Colorado. Results Of 307 identified infections, median age was 6 years, 61% were male, 66% had underlying medical conditions. Eighty (26%) admitted ICU. Thirty-two (40%) ICU patients...
To analyze the spectrum of neurological manifestations in children hospitalized with pandemic influenza A H1N1 virus 2009 (pH1N1).Retrospective case series from May 1, 2009, through November 30, 2009.Tertiary-care children's hospital Colorado.All patients pH1N1 consult or diagnosis, lumbar puncture, electroencephalogram, neuroimaging were selected as suspected cases. These systematically reviewed and for final analysis if confirmed by pre-established definitions a complication.Of 307 pH1N1,...
This study characterizes the percentage of pediatric patients undergoing liver transplant who were up to date for their age on immunizations at time and risk factors underimmunization.
Endotracheal aspirate cultures (EACs) help diagnose lower respiratory tract infections in mechanically ventilated patients but are limited by contamination with normal microbiota and variation laboratory reporting. Increased use of EACs is associated increased antimicrobial prescribing, the impact microbiology reporting on prescribing practices unclear. This study was a retrospective analysis from at Children's Hospital Colorado (CHCO) admitted between 1 January 2019 31 December 2019. Chart...
Objective: In 2014, the Unites States experienced an outbreak of enterovirus D68 associated with severe respiratory illness. The clinical characteristics illness from during this compared those 2009 H1N1 influenza virus are unknown. Design and Setting: retrospective cohort study, we characterized features children admitted to PICU between August 1, November them critically ill infected pandemic May 2009, January 31, 2010. Patients: patients. Interventions: None. Measurements Main Results:...
In the absence of evidence-based laboratory guidelines, workup and interpretation tracheal aspirate (TA) cultures remains controversial confusing within fields clinical microbiology, infectious diseases, critical care. Between 22 January 24 February 2020, we conducted a national, web-based survey microbiology personnel in free-standing pediatric hospitals adult containing facilities regarding practices used for TA specimens.
Abstract Background Historically, the IDSA and AST have recommended that live vaccines not be administered post‐transplant due to concern for induction of vaccine‐strain disease in immunocompromised hosts. However, recent prospective studies revised guidelines published April 2019 suggest current era immunosuppression minimization, may safely select transplant recipients with resulting immunoprotection. The goal this study was assess vaccine practices at individual pediatric liver centers...
Patients in the ICU are at greatest risk of contracting healthcare-associated infections like methicillin-resistant Staphylococcus aureus. This study calculates cost-effectiveness S aureus prevention strategies and recommends specific based on screening test implementation.A analysis using a Markov model from hospital perspective was conducted to determine if implementation costs justified by associated reductions improvements quality-adjusted life years. Univariate probabilistic sensitivity...
Following hematopoietic stem cell transplant (HSCT), patients are at increased risk of vaccine-preventable diseases (VPDs) and experience worse outcomes VPDs compared to immunocompetent patients. Therefore, routinely vaccinated post-HSCT restore VPD immunity. Published guidelines recommend revaccination based on time post-HSCT, although optimal timing the value using other clinical laboratory variables guide remain unclear. An institutional immune recovery-based protocol is used Children's...
During the past two decades, there has been tremendous investment in ability to intervene disaster settings, and significant barriers remain providing appropriate services populations affected by natural man-made calamities. Many of effective assistance exist within NGO community, illustrate emerging needs for international agencies. These include improving methods recipient participation promote local health system, developing improved quality assurance, enhancing options personnel...
Background: Posaconazole is a broad-spectrum antifungal used for prophylaxis and treatment of invasive fungal infections. There no published data to inform prescribers on dosing the intravenous (IV) formulation in pediatric population. We describe our experience including dosing, serum concentrations, tolerability. Observations: Four patients (3 9 y) received IV posaconazole documented/suspected Patients achieved therapeutic concentrations daily doses 8.4 12.2 mg/kg adverse effects were...
Objectives We investigated immune determinants of antibody responses and B-cell memory to pH1N1 vaccine in HIV-infected children. Methods Ninety subjects 4 <25 years age received two double doses vaccine. Serum cells were frozen at baseline, after each vaccination, 28 weeks post-immunization. Hemagglutination inhibition (HAI) titers, avidity indices (AI), subsets, IgG IgA antigen secreting (ASC) measured baseline vaccination. Neutralizing antibodies pH1N1-specific Th1, Th2 Tfh cytokines...
The live-attenuated influenza vaccine (LAIV) has generally been more efficacious than the inactivated in children. However, LAIV is not recommended for HIV-infected children because of insufficient data. We compared cellular, humoral, and mucosal immune responses to 2013-2014 quadrivalent (LAIV4) uninfected 2-25 years age (yoa). analyzed H1N1 (H1N1-09), circulating (H1N1-14), which had significant mutations H1N1-09 B Yamagata (BY), highest effectiveness 2013-2014. Forty-six 56 participants...