A5024117754- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- School Health and Nursing Education
- Esophageal and GI Pathology
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Adolescent and Pediatric Healthcare
- Vitamin D Research Studies
- Pharmaceutical studies and practices
- Noise Effects and Management
- Congenital Diaphragmatic Hernia Studies
- COVID-19 and healthcare impacts
- Histiocytic Disorders and Treatments
- Pregnancy and Medication Impact
- Smoking Behavior and Cessation
- Mobile Health and mHealth Applications
- Long-Term Effects of COVID-19
- Telemedicine and Telehealth Implementation
Harvard University
2011-2024
Boston Children's Hospital
2011-2024
Boston Children's Museum
2020-2021
Harvard University Press
2021
Children's Medical Center
2021
Connecticut Children's Medical Center
2014-2020
University of Connecticut
2014-2020
Hartford Financial Services (United States)
2016-2019
UConn Health
2019
Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet cellular mechanisms that induce B cells to produce IgE response allergens remain poorly understood. T follicular helper (TFH) direct affinity and isotype antibodies produced by cells. Although TFH cell-derived interleukin-4 (IL-4) is necessary for production, it not sufficient. We report a rare population IL-13-producing present mice humans with allergens, but when...
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are generally asymptomatic or have mild symptoms low rates of hospitalization (<2%) and death (<0.03%).1 After initial infection, some children, including those who experienced disease, develop other postacute manifestations COVID, multisystem inflammatory in children (MIS-C, not discussed this statement) sequelae SARS-CoV-2 infection. The latter post-COVID condition may be known as long long-haul COVID-19,...
Rationale: Patients with cystic fibrosis (CF) have high rates of vitamin D insufficiency. The relation between status and inflammation in patients CF is poorly understood.Objectives: To determine the prevalence deficiency insufficiency a young population to examine correlations status, disease severity, inflammatory markers.Methods: This was retrospective chart review under age 12 years. Serum laboratory parameters, growth indices, pancreatic CFTR genetics, medications, microbiology,...
: With improvements in neonatal intensive care, more premature infants are surviving. Many have significant pulmonary morbidities after discharge from the hospital. Bronchopulmonary dysplasia is most common morbidity of prematurity and a indication for home oxygen therapy children. Data lacking on appropriate methods weaning supplemental oxygen. The objective this study was to identify used by pediatric pulmonologists wean oxygen.: One hundred eighty-four questionnaires were sent at 20...
Abstract Objective To define reference ranges for oxygen saturation (SpO 2 ) values in healthy full‐term infants the first days of life and preterm off supplemental as they approach neonatal intensive care unit (NICU) discharge. Methods From April 2009 to March 2010, we enrolled convenience samples from newborn nursery former who did not require at time discharge NICU. Overnight SpO signal quality recordings were obtained analyzed duration artifact‐free recording (AFRT), (s) with less than...
To determine if a home oxygen therapy (HOT) management strategy that includes analysis of recorded oximetry (RHO) data, compared with standard monthly clinic visit assessments, reduces duration HOT without harm in premature infants.The RHO trial was an unmasked randomized clinical conducted 9 US medical centers from November 2013 to December 2017, follow-up February 2019. Preterm infants birth gestation ≤37 + 0/7 weeks, discharged on HOT, and attending their first pulmonary were enrolled....
Abstract Objectives Psychological comorbidities have been associated with asthma in adults and children, but not studied a population of children severe asthma. The aim this study was to test the hypothesis that symptoms anxiety or depression are highly prevalent pediatric negatively effects control. Methods Longitudinal assessments (Patient Health Questionnaire‐4 [PHQ‐4]), control (Asthma Control Test [ACT]), lung function were performed single‐center clinic. Participant data collected...
Ultrastructural examination of cilia is the "gold standard" for diagnosing primary ciliary dyskinesia. There little evidence suggesting most effective method procuring a biopsy and scant benchmark data on rates conclusive biopsies or diagnostic impact such biopsies. To critically assess inconclusive, positive, negative to identify clinical factors associated with results, we reviewed submitted electron microscopy from 2006 2011, noting whether specimens were adequate analysis structure was...
OBJECTIVES The coronavirus pandemic created significant, abrupt challenges to the delivery of ambulatory health care. Because tertiary medical centers limited elective in-person services, telehealth was rapidly enacted in settings with minimal previous experience allow continued access With this quality improvement (QI) initiative, we aimed achieve a virtual visit volume at least 75% our prepandemic volume. We also describe patient and provider services. METHODS Our QI team identified...
Abstract Objective To evaluate management strategies and pulmonary outcomes for breastfed infants with oropharyngeal dysphagia. Study Design We performed a retrospective cohort study of diagnosed dysphagia documented aspiration or laryngeal penetration on videofluoroscopic swallow (VFSS). Medical records were reviewed VFSS results speech‐language pathologist recommendations following VFSS, chest x‐ray, bronchoalveolar lavage (BAL) within 1 year aspiration‐related hospitalizations occurring...
Current methods of assessing adherence are inaccurate. Electronic monitoring devices (EMDs) may more accurately assess adherence, but not currently used in practice. The design, methods, and participant baseline characteristics described for a pilot trial the effects an EMD on asthma medication pediatric population.This was pilot, randomized, controlled children with persistent managed daily inhaled corticosteroids (ICS). Seventy-five were randomized 2:1 to receive either two EMDs (one ICS...
Abstract Objective To evaluate gastrointestinal (GI) risk factors for bronchiectasis in children. We hypothesized that upper GI tract dysmotility would be associated with increased of bronchiectasis. Study design Subjects this retrospective cohort study included those evaluated persistent pulmonary symptoms the Aerodigestive Center at Boston Children's Hospital who underwent chest computed tomography (CT) between 2002 and 2019. determine predictors bronchiectasis, baseline characteristics,...