A5069455100- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Noise Effects and Management
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Indoor Air Quality and Microbial Exposure
- Climate Change and Health Impacts
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Cystic Fibrosis Research Advances
- Pharmaceutical studies and practices
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Food Allergy and Anaphylaxis Research
- Insects and Parasite Interactions
- Radioactivity and Radon Measurements
- Dermatology and Skin Diseases
- Adolescent and Pediatric Healthcare
- Air Quality Monitoring and Forecasting
- Respiratory viral infections research
- Neuroscience of respiration and sleep
- Child and Adolescent Health
- Obstructive Sleep Apnea Research
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
University of Miami
2024
Boston Children's Museum
2015-2024
Pulmonary Associates
2021
State Key Laboratory of Respiratory Disease
2017
Brigham and Women's Hospital
2015
Harvard University Press
2012-2014
Office of Infectious Diseases
2010
Children's Hospital
2010
Reducing asthma exacerbation frequency is an important criterion for approval of therapies, but the clinical features exacerbation-prone (EPA) remain incompletely defined.To describe clinical, physiologic, inflammatory, and comorbidity factors associated with EPA.Baseline data from NHLBI Severe Asthma Research Program (SARP)-3 were analyzed. An was defined as a burst systemic corticosteroids lasting 3 days or more. Patients classified by their number exacerbations in past year: none, few...
<h3>Importance</h3> Many preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to pathogenesis. Strategies that effectively attenuate such needed. <h3>Objective</h3> To evaluate if early administration azithromycin, started prior the onset LRTI symptoms, in with recurrent LRTIs can prevent progression these episodes. <h3>Design, Setting, and Participants</h3> A randomized,...
Asthma exacerbations occur frequently despite the regular use of asthma-controller therapies, such as inhaled glucocorticoids. Clinicians commonly increase doses glucocorticoids at early signs loss asthma control. However, data on safety and efficacy this strategy in children are limited.We studied 254 children, 5 to 11 years age, who had mild-to-moderate persistent least one exacerbation treated with systemic previous year. Children were for 48 weeks maintenance low-dose (fluticasone...
Objectives. The forced expiratory volume in 1 second (FEV1) felt to be an objective measure of airway obstruction is often normal asthmatic children. flow between 25% and 75% vital capacity (FEF25–75) reflects small patency has been found reduced children with asthma. aim this study was determine whether FEF25–75 associated increased childhood asthma severity morbidity the setting a FEV1, bronchodilator responsiveness (BDR) as defined by identifies more asthmatics than does BDR FEV1....
<h3>Importance</h3> Home aeroallergen exposure is associated with increased asthma morbidity in children, yet little known about the contribution of school exposures to such morbidity. <h3>Objective</h3> To evaluate effect school-specific on among students, adjusting for home exposures. <h3>Design, Setting, and Participants</h3> The School Inner-City Asthma Study was a prospective cohort study evaluating 284 students aged 4 13 years who were enrolled from 37 inner-city elementary schools...
Phenotypic distinctions between severe asthma (SA) and nonsevere (NONSA) may be confounded by differential adherence or incorrect use of corticosteroids.
Although pre-puberty asthma is more prevalent in males, after puberty through middle-age, females. The surge of sex hormones with might explain this gender switch. To examine the effects on lung function and symptoms puberty, Tanner stage was assessed 187 children 6–18 years age (59% severe) enrolled NIH/NHLBI Severe Asthma Research Program (SARP). circulating (n = 68; testosterone, dehydroepiandrosterone sulfate (DHEA-S), estrogen, progesterone) 4 week symptom control (ACQ6) cross-section...
Children spend over 6 h a day in schools and have higher asthma morbidity from school environmental exposures. The present study aims to determine indoor outdoor possible sources affecting PM2.5 classrooms. Weeklong samples were collected 32 inner-city Northeastern U.S. community during three seasons (fall, winter spring) the years 2009 2013. Concurrently, daily taken at central monitoring site located median distance of 4974 m (range 1065–11,592 m) schools. Classroom concentrations (an...
<h3>Importance</h3> School and classroom allergens particles are associated with asthma morbidity, but the benefit of environmental remediation is not known. <h3>Objective</h3> To determine whether use a school-wide integrated pest management (IPM) program or high-efficiency particulate air (HEPA) filter purifiers in classrooms improve symptoms students active asthma. <h3>Design, Setting, Participants</h3> Factorial randomized clinical trial IPM HEPA was conducted from 2015 to 2020 (School...
To cite this article: Permaul P, Hoffman E, Fu C, Sheehan W, Baxi S, Gaffin J, Lane Bailey A, King Chapman M, Gold D, Phipatanakul W. Allergens in urban schools and homes of children with asthma. Pediatr Allergy Immunol 2012: 23 : 543–549. Abstract Background: Most studies indoor allergens have focused on the home environment. However, may be an important site allergen exposure for We compared school to a cohort Correlations between settled dust airborne levels classrooms were examined....
Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that be avoided in children with asthma; however, appropriately designed trials evaluating this are lacking.In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 (age range, 12 59 months) mild persistent asthma assigned them receive either or ibuprofen when needed for the alleviation of fever...
Since there are known adverse health impacts of traffic-related air pollution, while at the same time potential benefits from greenness, it is important to examine more closely these factors on indoor quality in urban schools.
Background. Children spend a significant amount of time in school. Little is known about the role allergen exposure school environments and asthma morbidity. Objectives. The School Inner-City Asthma Study (SICAS) National Institutes Health (NIH)-funded prospective study evaluating school/classroom-specific risk factors morbidity among urban children. Methods/results. This article describes design, methods, important lessons learned from this extensive investigation. A single center...