A5040408813- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical studies and practices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacogenetics and Drug Metabolism
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Health Systems, Economic Evaluations, Quality of Life
- Emergency and Acute Care Studies
- Cystic Fibrosis Research Advances
- Allergic Rhinitis and Sensitization
- Ethics in Clinical Research
- Medication Adherence and Compliance
- Child and Adolescent Health
- Pharmacological Effects and Assays
- Respiratory Support and Mechanisms
- Healthcare cost, quality, practices
- Patient-Provider Communication in Healthcare
- IL-33, ST2, and ILC Pathways
- Biotechnology and Related Fields
- Eosinophilic Esophagitis
- Mobile Health and mHealth Applications
- Respiratory viral infections research
- Gastroesophageal reflux and treatments
Nemours Children's Health System
2016-2025
Nemours Children’s Clinic
2008-2023
Nemours Children's Clinic
2008-2021
Naval Medical Center Portsmouth
2021
Lincoln Memorial University
2021
PharmacoGenetics (China)
2021
National Institutes of Health
2020
National Heart Lung and Blood Institute
2020
University of Central Florida
2019
Florida College
2019
<h3>Context</h3>Asymptomatic gastroesophageal reflux (GER) is prevalent in children with asthma. Untreated GER has been postulated to be a cause of inadequate asthma control despite inhaled corticosteroid treatment, but it not known whether treatment proton pump inhibitors improves control.<h3>Objective</h3>To determine lansoprazole effective reducing symptoms without overt GER.<h3>Design, Setting, and Participants</h3>The Study Acid Reflux Children With Asthma, randomized, masked,...
Asthma exacerbations occur frequently despite the regular use of asthma-controller therapies, such as inhaled glucocorticoids. Clinicians commonly increase doses glucocorticoids at early signs loss asthma control. However, data on safety and efficacy this strategy in children are limited.We studied 254 children, 5 to 11 years age, who had mild-to-moderate persistent least one exacerbation treated with systemic previous year. Children were for 48 weeks maintenance low-dose (fluticasone...
In many patients with mild, persistent asthma, the percentage of eosinophils in sputum is less than 2% (low eosinophil level). The appropriate treatment for these unknown.
Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that be avoided in children with asthma; however, appropriately designed trials evaluating this are lacking.In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 (age range, 12 59 months) mild persistent asthma assigned them receive either or ibuprofen when needed for the alleviation of fever...
Morbidity from asthma is disproportionately higher among black patients than white patients, and constitute the minority of participants in trials informing treatment. Data indicate that with inadequately controlled benefit more addition a long-acting beta-agonist (LABA) increased glucocorticoids; however, these data may not be informative for treatment patients.
The value of utilizing a multigene pharmacogenetic panel to tailor pharmacotherapy is contingent on the prevalence prescribed medications with an actionable association. Clinical Pharmacogenetics Implementation Consortium (CPIC) has categorized over 35 gene-drug pairs as "level A," for which there sufficiently strong evidence recommend that genetic information be used guide drug prescribing. opportunity use among adult patients was determined by elucidating exposure CPIC level A drugs 11...
While there is growing scientific evidence for and significant advances in the use of genomic technologies medicine, a lag clinical adoption sustainability medicine. Here we describe findings from National Human Genome Research Institute's (NHGRI) Implementing GeNomics In pracTicE (IGNITE) Network identifying key constructs, opportunities, challenges associated with driving medicine practice.Network members affiliates were surveyed to identify drivers implementing sustaining program. Tallied...
<h3>Importance</h3> Genotype-guided prescribing in pediatrics could prevent adverse drug reactions and improve therapeutic response. Clinical pharmacogenetic implementation guidelines are available for many medications commonly prescribed to children. Frequencies of medication prescription actionable genotypes (genotypes where a change may be indicated) inform the potential value implementation. <h3>Objective</h3> To assess opportunities genotype-guided pediatric populations among multiple...
Objectives: This study aims to evaluate patient characteristics associated with bronchodilator (BD) use at various stages of bronchiolitis illness and corresponding outcomes in the emergency department (ED). Methods: retrospective, cross-sectional involves secondary data analysis from a sample 932 children ages 3 24 months who received diagnosis during an ED visit (1057 cases). Predictor variables included demographics, past medical history, family physical findings, medication use,...
Little is known about economic and productivity loss by severity of asthma. We investigate health-care utilization, direct medical costs, indirect costs due to from asthma severity.We conducted a cross-sectional analysis the Medical Expenditure Panel Survey database (2010-2017) patients with aged ≥12 years categorized them into mild, moderate, severe groups based on symptom control medications. Study outcomes included asthma-related absenteeism. used zero-inflated Poisson regression models...