A5045134254- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Mesoporous Materials and Catalysis
- Neonatal Respiratory Health Research
- Nitric Oxide and Endothelin Effects
- Reproductive Physiology in Livestock
- Respiratory Support and Mechanisms
- Phase Equilibria and Thermodynamics
- Pharmacological Effects and Assays
- Zeolite Catalysis and Synthesis
- Pediatric health and respiratory diseases
- Reproductive Biology and Fertility
- Vector-borne infectious diseases
- Sperm and Testicular Function
- Analytical Chemistry and Chromatography
- Blood Pressure and Hypertension Studies
- Smoking Behavior and Cessation
- Diabetes Treatment and Management
- Heart Rate Variability and Autonomic Control
- Catalysis and Oxidation Reactions
- Cystic Fibrosis Research Advances
- Viral Infections and Vectors
- Drug Solubulity and Delivery Systems
McGill University
2024-2025
University College Cork
2002-2022
Teagasc - The Irish Agriculture and Food Development Authority
1995-2021
Cyclerion (United States)
2019-2020
John Wiley & Sons (United States)
2019
Healthcare Technology Systems
2019
Ironwood Pharmaceuticals (United States)
2016-2018
Precision Research Institute
2018
Icon Early Phase Services
2016
Canadian Respiratory Research Network
2016
We isolated spirochetes from the blood of 2 36 patients in Long Island and Westchester County, New York, who had signs symptoms suggestive Lyme disease. The were morphologically similar serologically identical to organisms recently found infect Ixodes dammini ticks, which are endemic area have been epidemiologically implicated as vectors In both patients, there was a rise specific antispirochetal antibodies paired specimens serum. conclude that I. spirochete has an etiologic role (N Engl J...
We studied the effect of prenatal maternal cigarette smoking on pulmonary function (PF) 80 healthy infants tested shortly after birth (mean, 4.2 ± 1.9 wk). Mothers' was measured by: (1) questionnaire reports at each visit number cigarettes smoked per day, and (2) urine cotinine concentrations (corrected for creatlnine) obtained visit. Infant PF assessed by partial expiratory flow-volume curves hellum-dilutlon measurement FRC. Forced flow rates were significantly lower in born to mothers,...
Journal Article Surveillance of Lyme Disease in the United States, 1982 Get access George P. Schmid, Schmid Search for other works by this author on: Oxford Academic PubMed Google Scholar Rose Horsley, Horsley Allen C. Steere, Steere John Hanrahan, Hanrahan Jeffrey Davis, Davis G. Stephen Bowen, Bowen Michael T. Osterholm, Osterholm Jason S. Weisfeld, Weisfeld W. Hightower, Hightower Claire V. Broome The Infectious Diseases, Volume 151, Issue 6, June 1985, Pages 1144–1149,...
The relationship between initial level of lung function and subsequent wheezing, lower respiratory illness (LRI) was studied in 97 infants whom the first measurement pulmonary (PFT) made before 6 months age. Occurrence LRI evaluated by standardized questionnaires at each well-baby visit, biweekly telephone calls to mothers, review all visits physicians. Infant PFT assessed partial expiratory flow-volume curves helium-dilution functional residual capacity (FRC). Maternal, prenatal smoking...
The present investigation evaluated the effects of maternal smoking during pregnancy on growth lung function first 18 mo life in 159 infants who were part a longitudinal study respiratory health. Infant pulmonary was assessed at 2 to 6 wk age and 4 6, 9 12, 15 by partial expiratory flow-volume curves helium dilution FRC. Maternal standard questionnaire urine cotinine measurements. associated with reduction 9.4 +/- 4.3 ml (p = 0.029) for FRC 33 12.3 ml/s 0.008) flow (VFRC) after controlling...
Genotoxicity of commercial colloidal and laboratory-synthesized silica nanoparticles was tested using the single cell gel electrophoresis or Comet assay. By a carefully developed protocol careful characterization nanoparticle dispersions, assays were performed on 3T3-L1 fibroblasts with 3, 6, 24 h incubations 4 40 μg/ml nanoparticles. No significant genotoxicity observed for under conditions described, results independently validated in two separate laboratories, showing that vitro toxicity...
BACKGROUND: Most studies of the reproductive consequences cigarette smoking base exposure on self-reported habits. This study examines relationship birth outcomes to timing and intensity maternal active passive estimated both from self-reports cotinine concentration in urine during early, middle, late gestation. METHOD: cohort included 740 white Hispanic women who obtained antenatal care at East Boston Neighborhood Health Center between 1986 1992. At each visit, information was by a detailed...
Consumption of raw shellfish has long been known to be associated with individual cases and sporadic outbreaks enteric illness. However, during 1982, gastroenteritis eating reached epidemic proportions in New York State. Between May 1 December 31, there were 103 well-documented which 1017 persons became ill: 813 related clams, 204 oysters. The most common symptoms diarrhea, nausea, abdominal cramps, vomiting. Incubation periods generally 24 48 hours long, the duration illness was hours....
Spirochetes believed to be the cause of Lyme disease were isolated from white-footed mice and white-tailed deer, preferred natural hosts Ixodes dammini , tick vector. Evidence suggests that deer act as a reservoir provide an overwintering mechanism for both spirochetes adult ticks. Some larvae may acquire spirochete by transovarial passage nymphal stage transmit humans.
Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV(1)) before and after the administration a short-acting β(2)-agonist, most common rescue medications used for treatment asthma. BDR also serves as test β(2)-agonist efficacy. complex trait partly under genetic control. A genome-wide association study (GWAS) BDR, quantified percent change in baseline FEV(1) was performed with 1,644 non-Hispanic...
Inhaled beta-agonists are one of the most widely used classes drugs for treatment asthma. However, a substantial proportion patients with asthma do not have favorable response to these drugs, and identifying genetic determinants drug may aid in tailoring individual patients.To screen variants candidate genes steroid beta-adrenergic pathways association inhaled beta-agonists.We genotyped 844 single nucleotide polymorphisms (SNPs) 111 209 children their parents participating Childhood Asthma...
We conducted an epidemiological study of the cumulative frequency and incidence Lyme disease in a summer community on Fire Island, New York, area endemic for disease. Fifteen (7.5%) 200 persons studied 1982 reported history An indirect immunofluorescent antibody assay showed that seventeen (9.7%) 176 had serological evidence exposure to spirochete, including six 15 with Seven (0.7%-1.2%) 600-1,000 developed clinical symptoms during season, two (1%) group. Four (3.1%) 129 who sera collected...
Nanomaterials such as SiO2 nanoparticles (SiO2NP) are finding increasing applications in the biomedical and biotechnological fields disease diagnostics, imaging, drug delivery, food, cosmetics biosensors development. Thus, a mechanistic systematic evaluation of potential biological toxic effects SiO2NP becomes crucial order to assess their complete safe applicability limits. In this study, human monocytic leukemia cell line THP-1 alveolar epithelial A549 were exposed range amorphous various...
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We conducted 151 tests of pulmonary function (PF) on 72 healthy infants younger than 2 yr age using partial expiratory flow volume (PEFV) maneuvers and helium dilution determination FRC. After were grouped into four strata based postconception (PC) age, variability sex differences in level PF examined. No significant found for any measure stratum, even when somatic size was controlled by length correction. Force measures, however, tended to be greater girls boys the youngest infants. Flow...
Seven cases of nosocomial legionellosis occurred between February and September 1982 in a small community hospital Upstate New York. All seven were Legionella pneumophila serogroup 1; six patients one employee. None the died. During peak outbreak, incidence was 1.2 per 100 patient discharges. An epidemiologic comparison with 21 matched controls suggested that longer stay (ξ12 = 24.2, p < 0.001) proximity patients' rooms to ward showers 4.4, 0.04) significant risk factors for acquiring...
The abnormally viscous and thick mucus is a hallmark of cystic fibrosis (CF). How the mutated CF gene causes abnormal remains an unanswered question paramount interest. Mucus produced by hydration gel-forming mucin macromolecules that are stored in intracellular granules prior to release. Current understanding mucin/mucus structure before after secretion limited, contradictory models exist. Here, we used molecular viscometer fluorescence lifetime imaging human bronchoepithelial cells (Normal...
OBJECTIVES: This study examined the degree to which breast-feeding and cigarette smoking by mothers other household members contribute exposure of infants products tobacco smoke. METHODS: The subjects were 330 mother-infant pairs derived from a cohort 1000 enrolled in longitudinal pulmonary effects prenatal postnatal smoking. main outcome measure was corrected urinary cotinine levels. RESULTS: Urinary levels 10-fold higher breast-fed than among bottle-fed mothers. Among nonsmoking mothers,...
Four incidents of mushroom poisoning, representing four the seven established groups toxic mushrooms, are presented. These case reports illustrate range gastrointestinal and neurological symptoms caused by poisoning reflect a nationwide increase in serious poisonings recent years. Severity often parallels time span between consumption onset symptoms, with having longer incubation periods. New therapies for amatoxin may reduce mortality these poisonings. (<i>JAMA</i>1984;251:1057-1061)