A5030283020- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Microfluidic and Bio-sensing Technologies
- Inhalation and Respiratory Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Air Quality and Health Impacts
- Advanced biosensing and bioanalysis techniques
- Characterization and Applications of Magnetic Nanoparticles
- Biosimilars and Bioanalytical Methods
- Occupational and environmental lung diseases
- Cancer Cells and Metastasis
- Cell Image Analysis Techniques
- Neuroscience and Neural Engineering
- Molecular Communication and Nanonetworks
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- RNA Interference and Gene Delivery
- Animal testing and alternatives
- Quantum Dots Synthesis And Properties
- Advanced Biosensing Techniques and Applications
- Ultrasound and Hyperthermia Applications
- MicroRNA in disease regulation
Trinity College Dublin
2016-2025
St. James's Hospital
2012-2025
Advanced Materials and BioEngineering Research
2015-2024
Cancer Institute (WIA)
2024
National Physical Laboratory
2022
Molecular Medicine Ireland
2014-2022
European Commission
2022
Indiana University School of Medicine
2019
22q11 Ireland
2019
Madrid Institute for Advanced Studies
2015
Abstract Introduction Tumor cells can effectively be killed by heat, e.g. using magnetic hyperthermia. The main challenge in the field, however, is generation of therapeutic temperatures selectively whole tumor region. We aimed to improve hyperthermia breast cancer innovative nanoparticles which display a high heating potential and are functionalized with cell internalization chemotherapeutic agent increase death. Methods superparamagnetic iron oxide (MF66) were electrostatically either...
The implementation of the proposal from European Chemical Agency (ECHA) to restrict use nanoplastics (NP) and microplastics (MP) in consumer products will require reliable methods perform size mass-based concentration measurements. Analytical challenges arise at nanometre micrometre interface, e.g., 800 nm–10 µm, where techniques applicable scale reach their upper limit applicability approaches must be pushed lower limits detection. Herein, we compared performances nine analytical by...
The availability of analytical methods for the characterization lipid nanoparticles (LNPs) in-vivo intracellular delivery nucleic acids is critical fast development innovative RNA therapies. In this study, protocols to measure (i) chemical composition, (ii) drug loading, (iii) particle size, concentration, and stability as well (iv) structure morphology were evaluated compared based on a comprehensive strategy linking key physical properties in-vitro efficacy toxicity. Furthermore,...
One of the key challenges in field nanoparticle (NP) analysis is producing reliable and reproducible characterisation data for nanomaterials. This study looks at reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on range particle sizes materials several different media. It describes protocol development presents both results obtained from 12 laboratories, mostly based Europe, who are primarily QualityNano members. an EU FP7 funded...
Suspicion has been raised that high aspect ratio nanoparticles or nanofibers might possess asbestos-like pathogenicity. The pleural space is a specific target for disease in individuals exposed to asbestos and by implication of nanofibers. Pleural effects fibers depends on fiber length, but the key threshold length beyond which adverse occur never identified till now because all vitreous samples are heterogeneously distributed their length. Nanotechnology advantageously allows highly defined...
Silver nanoparticle-based antimicrobials can promote a long lasting bactericidal effect without detrimental toxic side effects. However, there is not clear and complete protocol to define relate the properties of particles (size, shape, surface charge, ionic content) with their specific activity. In this paper, we propose an effective multi-step approach for identification 'purpose-specific active applicability window' maximize antimicrobial activity medical devices containing silver...
Abstract: Vascular endothelium is a potential target for therapeutic intervention in diverse pathological processes, including inflammation, atherosclerosis, and thrombosis. By virtue of their intravascular topography, endothelial cells are exposed to dynamically changing mechanical forces that generated by blood flow. In the present study, we investigated interactions negatively charged 2.7 nm 4.7 CdTe quantum dots 50 silica particles with cultured under regulated shear stress (SS)...
The use of nanotechnology in medical products has been demonstrated at laboratory scale, and many resulting nanomedicines are the translational phase toward clinical applications, with global market trends indicating strong growth sector coming years. translation clinic subsequent commercialization may require development new or adaptation existing standards to ensure quality, safety efficacy such products. This work addresses some identified needs, illustrates shortcomings currently used...
Different superparamagnetic iron oxide nanoparticles have been tested for their potential use in cancer treatment, as they enter into cells with high effectiveness, do not induce cytotoxicity, and are retained relatively long periods of time inside the cells. We analyzed interaction, internalization biocompatibility dimercaptosuccinic acid-coated an average diameter 15 nm negative surface charge MCF-7 breast Cells were incubated different intervals, ranging from 0.5 to 72 h. These showed...
Abstract: The main objective of this study was to optimize and characterize a drug delivery carrier for doxorubicin, intended be intravenously administered, capable improving the therapeutic index chemotherapeutic agent itself, aimed at treatment pancreatic cancer. In light goal, we report robust one-step method synthesis dicarboxylic acid-terminated polyethylene glycol (PEG)-gold nanoparticles (AuNPs) doxorubicin-loaded PEG-AuNPs, their further antibody targeting (anti-Kv11.1 polyclonal...
When assessing the risk and hazard of a non-pharmaceutical compound, first step is determining acute toxicity, including toxicity following inhalation. Inhalation major exposure route for humans, respiratory epithelium tissue that inhaled substances directly interact with. Acute inhalation testing regulatory purposes currently performed only in rats and/or mice according to OECD TG403, TG436, TG433 test guidelines. Such tests are biased by differences tract architecture function across...
The measurement of physicochemical properties polydisperse complex biological samples, for example, extracellular vesicles, is critical to assess their quality, resulting from production and isolation methods. community gradually becoming aware the need combine multiple orthogonal techniques perform a robust characterization samples. Three pillars quality attribute EVs are sizing, concentration phenotyping. repeatable vesicle one key-challenges that requires further efforts, in order obtain...
Particle size distribution and stability are key attributes for the evaluation of safety efficacy profile medical nanoparticles (Med-NPs). Measuring particle average is a challenging task which requires combination orthogonal high-resolution sizing techniques, especially in complex biological media. Unfortunately, despite its limitations, due to accessibility, low cost, easy handling, batch mode dynamic light scattering (DLS) still very often used as only approach measure nanomedicine field....