A5080738993- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Microplastics and Plastic Pollution
- Biotechnology and Related Fields
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Analytical chemistry methods development
- Environmental Toxicology and Ecotoxicology
- Biomedical Ethics and Regulation
- Healthcare and Environmental Waste Management
- Carbon Nanotubes in Composites
- Electrochemical Analysis and Applications
- Sensor Technology and Measurement Systems
- Vitamin C and Antioxidants Research
- Scientific Measurement and Uncertainty Evaluation
- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Pesticide Residue Analysis and Safety
- Computational Drug Discovery Methods
- Gold and Silver Nanoparticles Synthesis and Applications
- Chemistry and Chemical Engineering
- Biosensors and Analytical Detection
- Nanotechnology research and applications
- Coagulation and Flocculation Studies
Swiss Federal Laboratories for Materials Science and Technology
2002-2023
University of St. Gallen
2013-2019
One of the key challenges in field nanoparticle (NP) analysis is producing reliable and reproducible characterisation data for nanomaterials. This study looks at reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on range particle sizes materials several different media. It describes protocol development presents both results obtained from 12 laboratories, mostly based Europe, who are primarily QualityNano members. an EU FP7 funded...
Quality control of pharmaceutical and biopharmaceutical products, verification their safety efficacy, depends on reliable measurements critical quality attributes (CQAs). The task becomes particularly challenging for drug products vaccines containing nanomaterials, where multiple complex CQAs must be identified monitored. To reduce (i) the risk measurement bias (ii) uncertainty in decision-making during product development, combination orthogonal complementary analytical techniques are...
The release of reactive oxygen species (ROS) during the electron transport mitochondrial aerobic respiration is major source ROS. However, contact between cells and nanoparticles (NPs) can also induce ROS, leading to an imbalance towards pro-oxidative state. At low levels ROS production, initiate a protective response guarantee their survival, but excess damage cellular compounds such as membranes various organelles, or directly cause genotoxicity. Thus elevated level important indicator...
Nanosilver shows great promise for use in industrial, consumer or medical products because of its antimicrobial properties. However, the underlying mechanisms effects silver nanoparticles on human cells are still controversial. Therefore, present study influence chloride concentration and different serum content culture media cytotoxic nanosilver was systematically evaluated. Our results show that toxicity strongly affected by composition media. The concentration, as well carbon...
Microorganisms growing on painted surfaces are not only an aesthetic problem, but also actively contribute to the weathering and deterioration of materials. A widely used strategy combat microbial colonization is addition biocides paint. However, ecotoxic, non-degradable with a broad protection range now prohibited in Europe, so paint industry considering engineered nanoparticles (ENPs) as alternative biocide. There concern that ENPs might be released run-off water subsequently consumed by...
One of the greatest challenges in manufacturing and development nanotechnologies is requirement for robust, reliable, accurate characterization data. Presented here are results an interlaboratory comparison (ILC) brought about through multiple rounds engagement with NanoSight Malvern ten pan-European research facilities. Following refinement nanoparticle tracking analysis (NTA) technique, size concentration nanoparticles liquid suspension was proven to be robust reproducible sample types...
An early dialogue between nanomedicine developers and regulatory authorities are of utmost importance to anticipate quality safety requirements for these innovative health products. In order stimulate interactions the various communities involved in a translation nanomedicines clinical applications, European Commission's Joint Research Centre hosted workshop titled "Bridging field Nanomedicine" Ispra/Italy on 27th -28th September 2017. Experts from bodies, research institutions industry came...
We describe the outcome of a large international interlaboratory study measurement particle number concentration colloidal nanoparticles, project 10 technical working area 34, "Nanoparticle Populations" Versailles Project on Advanced Materials and Standards (VAMAS). A total 50 laboratories delivered results for 30 nm gold nanoparticles measured using tracking analysis (PTA), single inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy,...
Abstract The identification of regulatory challenges for nanotechnology-enabled health products, followed by discussions with the involved stakeholders, is first step towards a strategic planning how such can be successfully addressed in future. In order to better understand whether identified needs are sector-specific products or might also hinder progress other domains, REFINE consortium reached out communities representing sectors that exploit potential nanotechnology, i.e. industrial...
This paper describes a comprehensive investigation of particle number concentrations including multi-method comparison, theoretical modeling, and cellular dosimetry.
Abstract Engineered nanomaterials have unique and novel properties enabling wide-ranging new applications in nearly all fields of research. As these raised concerns about potential adverse effects for the environment human health, extensive efforts are underway to define reliable, cost- time-effective, as well mechanistic-based testing strategies replace current method animal testing, which is still most prevalent model used risk assessment chemicals. Current approaches follow this line. The...
The development of nanotechnology-enabled health products offers innovative therapeutic and diagnostic opportunities to address medical needs. At the moment, no specific regulatory framework exists for such since they can be covered by existing frameworks medicinal devices. However, these do require additional guidance fully cover particularities products. After a detailed analysis documents, standards, scientific publications originating mainly from Europe US, European project “REFINE” has...
The amount of engineered nanomaterials (ENM) is constantly increasing. Their unique properties, compared to their bulk counterparts, render them suitable for various applications in many areas life. Hence, appear a variety different consumer products leading the exposure human beings and environment during lifecycle. Even though results on biological effects ENM are available, harmonized validated test systems still missing. One major problem concerning reliable robust toxicity testing...