A5053220835- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Drug Solubulity and Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Nanoparticles: synthesis and applications
- Protein purification and stability
- Pharmaceutical Economics and Policy
- Hepatitis B Virus Studies
- Iron Metabolism and Disorders
- Barrier Structure and Function Studies
- Drug Transport and Resistance Mechanisms
- Hydrogels: synthesis, properties, applications
- Viral gastroenteritis research and epidemiology
- Polymer Surface Interaction Studies
- Monoclonal and Polyclonal Antibodies Research
- Wound Healing and Treatments
- Biosimilars and Bioanalytical Methods
- Antimicrobial agents and applications
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
University of Geneva
2016-2025
HES-SO University of Applied Sciences and Arts Western Switzerland
2019-2025
University of Lausanne
2012-2023
University Hospital of Lausanne
2018
New York Academy of Sciences
2017
John Wiley & Sons (United States)
2017
Hudson Institute
2017
Lygature
2016
HES-SO Genève
2015
Top Institute Pharma
2015
Nanomedicine is the application of nanotechnology to discipline medicine: use nanoscale materials for diagnosis, monitoring, control, prevention, and treatment disease. holds tremendous promise revolutionize medicine across disciplines specialties, but this has yet be fully realized. Beyond typical complications associated with drug development, fundamentally different novel physical chemical properties some nanomaterials compared on a larger scale (i.e., their bulk counterparts) can create...
In the present study, we evaluated polyethylenimine (PEI) of different molecular weights (MWs) as a DNA complexing agent for its efficiency in transfecting nondifferentiated COS-1 (green monkey fibroblasts) and well-differentiated human submucosal airway epithelial cells (Calu-3). Studying effect particle size, zeta potential, presence serum proteins or chloroquine, it appeared that transfection depends on experimental conditions not MW PEI used. Comparing efficiencies both cell lines, found...
Hyaluronic acid (HA) has been known to play an important role in wound healing process. However, the effect of molecular weight (MW) exogenously administered HA on process not fully understood. In this study, we investigated with different MWs using human epidermal keratinocytes and dermal fibroblasts. Cell proliferation migration ability were assessed by water soluble tetrazolium (WST) assay scratch assay. We examined addition a full-thickness model mice gene expression related healing....
Nanoparticles (NPs) assumed an important role in the area of drug delivery. Despite number studies including NPs are growing over last years, their side effects on immune system often ignored or omitted. One most studied polymers nano based delivery field is chitosan (Chit). In scientific literature, although physicochemical properties [molecular weight (MW) deacetylation degree (DDA)] chitosan, endotoxin contamination and appropriate testing controls rarely reported, they can strongly...
The therapeutic efficacy and adverse impacts of nanoparticles (NPs) are strongly dependent on their systemic circulation time. corona proteins adsorbed the NPs determine plasma half-lives, hence, it is crucial to identify shortening or extending In this work, in vivo time composition superparamagnetic iron oxide (SPIONs) with different surface charges/chemistries were analyzed over SPIONs neutral positive charges showed longest shortest times, respectively. most striking observation was that...
Solid tumors such as glioblastoma (GBM) exhibit hypoxic zones that are associated with poor prognosis and immunosuppression through multiple cell intrinsic mechanisms. However, release of extracellular vesicles (EVs) has the potential to transmit molecular cargos between cells. If cancer cells use EVs suppress functions macrophages under adequate oxygenation, this could be an important underlying mechanism contributing immunosuppressive immunologically cold tumor microenvironment GBM.