Because of their biocompatibility and unique magnetic properties, superparamagnetic iron oxide nanoparticles NPs (SPIONs) are recognized as some the most prominent agents for theranostic applications. Thus, understanding interaction SPIONs with biological systems is important safe design efficient In this study, were coated 2 different polymers: polyvinyl alcohol polymer (PVA) dextran. The obtained surface charges (positive, neutral negative) used a model study effect materials on protein...

Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials consumer and medical products. Several epidemiologic vitro studies have shown that nanoparticles can potential toxic effects. However, also offer opportunity to develop new therapeutic strategies treat specifically either pregnant mother or fetus. Previous mainly addressed whether are able cross placental barrier. transport mechanisms underlying...

As nanoparticles (NPs) are increasingly used in many applications their safety and efficient nanomedicine have become concerns. Protein coronas on nanomaterials' surfaces can influence how the cell "recognizes" nanoparticles, as well vitro vivo NPs' behaviors. The SuperParamagnetic Iron Oxide Nanoparticle (SPION) is one of most prominent agents because its superparamagnetic properties, which useful for separation applications. To mimic surface properties different types NPs, a core-shell...

The proteins adsorbed onto SPION coated with PVA different charges showed surprisingly behaviors<italic>in situ</italic>and<italic>ex situ</italic>.

The therapeutic efficacy and adverse impacts of nanoparticles (NPs) are strongly dependent on their systemic circulation time. corona proteins adsorbed the NPs determine plasma half-lives, hence, it is crucial to identify shortening or extending In this work, in vivo time composition superparamagnetic iron oxide (SPIONs) with different surface charges/chemistries were analyzed over SPIONs neutral positive charges showed longest shortest times, respectively. most striking observation was that...

Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal agents. These (NPs), with a specific nanoflower morphology, first synthesized simultaneously functionalized 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited low hydrodynamic size of 90 ± 2 nm. functional groups LDOPA (-NH2 -COOH) successfully used for the grafting molecules interest in second...

The aim of this study was to investigate the influence surface charge and coating Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on their in vitro vivo behaviors.Neutral negatively-charged PEG-based SPIONs were synthesized compared Resovist®, a carboxydextran-based SPION currently used clinics.Their cytotoxicity, cell internalization, potential as contrast agents for magnetic resonance imaging assessed.Neutral pegylated internalized less readily by reticuloendothelial system showed...

Nanotechnology is a rapidly expanding and highly promising new technology with many different fields of application. Consequently, the investigation engineered nanoparticles in biological systems steadily increasing. Questions about safety such are very important most critical subject regard to penetration barriers allowing particle distribution throughout human body. Such translocation studies technically challenging issues have be considered obtain meaningful comparable results. Here we...

Nanoparticles (NPs) in contact with biological fluids form a biomolecular corona through interactions proteins, lipids, and sugars, acquiring new physicochemical properties. This work explores the interaction between selected proteins (hemoglobin fetuin-A) that may alter NP circulation time NPs of different surface charges (neutral, positive, negative). The key albumin transferrin, two most abundant plasma was also studied. Binding affinity investigated using quartz crystal microbalance...

The functionalization of superparamagnetic iron oxide nanoparticles (SPIOs) by meso-2,3-dimercaptosuccinic acid (DMSA) was investigated. Under ambient conditions, the thiol groups from DMSA are not stable and do allow a direct without storage in stringent conditions or chemical regeneration free thiols. In this study, we have developed protocol based on poly(ethylene glycol) (PEG) grafting SPIO prior to anchoring. We observed that PEG helps increase stability under conditions. functionalized...

Abstract: Nanotechnology provides new opportunities in human medicine, mainly for diagnostic and therapeutic purposes. The autoimmune disease rheumatoid arthritis (RA) is often diagnosed after irreversible joint structural damage has occurred. There an urgent need a very early diagnosis of RA, which can be achieved by more sensitive imaging methods. Superparamagnetic iron oxide nanoparticles (SPION) are already used medicine therefore represent promising tool RA. focus our work was to...

Background Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety different diseases. For such in-vivo application, an additional coating with polymer, for example polyvinyl alcohol (PVA), is needed to stabilize the SPION and prevent aggregation. As particles foreign body, reaction against could occur. In this study we investigated effects that may have on experimental arthritis after intra-articular (i.a.) or intravenous (i.v.) injection. Methods...

For the first time, titanate nanotubes (TiONts) coated with USPIO (ultrasmall superparamagnetic iron oxide) without polymer functionalization and directly obtained during TiONts formation is reported. The coating of these tubes was performed hydrothermal synthesis. After this treatment, in strongly basic conditions, particles kept their structure magnetic properties while size distribution slightly increased. By coupling zeta-potential measurements TEM observations at different pH it...

The quantification of nanoparticles, particularly superparamagnetic iron oxide nanoparticles (SPIONs), both in vitro and vivo has become highly important recent years. Some methods, such as induced coupled plasma (ICP) spectroscopy UV-visible chemical titration using Prussian Blue (PB), already exist however they consist the whole content. These standard methods need sample preparations leading to their destruction long measurement time. In this study, we used magnetic susceptibility...

While it is well established that the surface of a nanoparticle plays pivotal role for protein corona, vast number proteins present in biological media render general conclusions about affinities between surfaces and nontrivial. Recently published articles increasingly reveal differences systems an ever increasing influencing factors corona. In contrast, study posits reported may, at least part, be due to poor experimental design, which leads biased results. The investigates adsorption onto...

In this work, new nanohybrids based on superparamagnetic iron oxide nanoparticles (SPIONs) were elaborated and discussed for the first time as nanovectors of a derivative molecule trans-resveratrol (RSV), natural antioxidant molecule, which can be useful brain disease treatment. The was chemically synthesized (4’-hydroxy-4-(3-aminopropoxy) trans-stilbene: HAPtS) then grafted onto SPIONs surface using an organosilane coupling agent, is 3-chloropropyltriethoxysilane (CPTES) nucleophilic...

Stable suspensions of citrated SPIO nanoparticles were synthesised in one step using a hydrothermal continuous process. Citrates control the crystallite size and oxidation degree metallic ions despite very short reaction time (4 s). Magnetite particles, Fe2.94O4, with an average 4 nm good monodispersity obtained.

Mesenchymal stromal cells (MSCs) are promising candidates in regenerative cell‐therapies. However, optimizing their number and route of delivery remains a critical issue, which can be addressed by monitoring the MSCs’ bio‐distribution vivo using super‐paramagnetic iron‐oxide nanoparticles (SPIONs). In this study, amino‐polyvinyl alcohol coated (A‐PVA) SPIONs introduced for cell‐labeling visualization magnetic resonance imaging (MRI) human MSCs. Size surface charge A‐PVA‐SPIONs differ...

Combined individually tailored methods for diagnosis and therapy (theragnostics) could be beneficial in destructive diseases, such as rheumatoid arthritis. Nanoparticles are promising candidates theragnostics due to their excellent biocompatibility. Nanoparticle modifications, improved surface coating, development meet various requirements, although safety concerns mean that modified nanoparticles require further review before use medical applications is permitted. We have previously...

Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to destruction. Studies have shown that RA treatment efficacy correlated synovial number. The aim of this study was experimentally validate the use in vivo superparamagnetic iron oxide nanoparticle (SPION) labeled macrophages evaluate MRI. evolution monitored with and without dexamethasone (Dexa) rats. Two doses 3 1 mg/kg Dexa...