A5014182307- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and biosynthesis
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Essential Oils and Antimicrobial Activity
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- Metabolism and Genetic Disorders
- Nanoparticles: synthesis and applications
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Neurological diseases and metabolism
- Bioactive natural compounds
- Biochemical Analysis and Sensing Techniques
- Steroid Chemistry and Biochemistry
Laboratoire Bio-peroxIL
2012-2024
Inserm
2014-2023
Université de Bourgogne
2014-2023
Université Bourgogne Franche-Comté
2019-2020
Lebanese University
2019
The effects of vegetable oils on human health depend their components. Therefore, profiles lipid nutrients and polyphenols were determined.To establish compare the fatty acid, tocopherol, phytosterol polyphenol Mediterranean oils: cosmetic dietary argan (AO; Morocco: Agadir, Berkane); olive (OO; Morocco, Spain, Tunisia); milk thistle seed (MTSO; Tunisia: Bizerte, Sousse, Zaghouane); nigella oil (NSO).The biochemical determined by gas chromatography-flame ionization, high performance liquid...
Lipid peroxidation products, such as 7-ketocholesterol (7KC), may be increased in the body fluids and tissues of patients with neurodegenerative diseases trigger microglial dysfunction involved neurodegeneration. It is therefore important to identify synthetic natural molecules able impair toxic effects 7KC. We determined impact 7KC on murine BV-2 cells, especially its ability mitochondrial peroxisomal dysfunction, evaluated protective α- γ-tocopherol, Trolox, oleic acid (OA). Multiple...
Polydopamine (pDA)-modified iron oxide core-shell nanoparticles (IONPs) are developed and designed as nanovectors of drugs. Reactive quinone pDA enhances the binding efficiency various biomolecules for targeted delivery. Glutathione disulfide (GSSG), an abundant thiol species in cytoplasm, was immobilized on pDA-IONP surface. It serves a cellular trigger to release drug from providing efficient platform delivery system. Additionally, GSSG surface further modified form S-nitrosoglutathione...
The Mediterranean diet is associated with health benefits due to bioactive compounds such as polyphenols. biological activities of three polyphenols (quercetin (QCT), resveratrol (RSV), apigenin (API)) were evaluated in mouse neuronal N2a cells the presence 7-ketocholesterol (7KC), a major cholesterol oxidation product increased patients age-related diseases, including neurodegenerative disorders. In cells, 7KC (50 µM; 48 h) induces cytotoxic effects characterized by an induction cell death....
In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects VLCFAs at mitochondrial level since dysfunctions play crucial roles neurodegeneration. On human neuronal SK-NB-E cells treated with or C26:0 (0.1-20 μM; 48 h), an inhibition cell growth and...
In the prevention of neurodegeneration associated with aging and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), neuronal differentiation is interest. this context, neurotrophic factors are a family peptides capable promoting growth, survival, and/or both developing immature neurons. contrast to these peptidyl compounds, polyphenols not degraded in intestinal tract able cross blood–brain barrier. Consequently, they could potentially be used as therapeutic agents...
Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well subjects concerned civilization (type 2 diabetes, bowel diseases, metabolic syndrome). The involvement increased 7-ketocholesterol pathophysiology these widely suspected. Indeed, elevated...
Argan oil is widely used in Morocco traditional medicine. Its ability to treat cardiovascular diseases well-established. However, nothing known about its effects on neurodegenerative diseases, which are often associated with increased oxidative stress leading lipid peroxidation and the formation of 7-ketocholesterol (7KC) resulting from cholesterol auto-oxidation. As 7KC induces stress, inflammation cell death, it important identify compounds able impair harmful effects. These may be either...