A5047191353- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Stochastic processes and statistical mechanics
- Metabolism and Genetic Disorders
- Enzyme-mediated dye degradation
- Cholesterol and Lipid Metabolism
- Phytochemicals and Antioxidant Activities
- Protein Interaction Studies and Fluorescence Analysis
- Diffusion and Search Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Metal-Catalyzed Oxygenation Mechanisms
- Markov Chains and Monte Carlo Methods
- Fatty Acid Research and Health
- Essential Oils and Antimicrobial Activity
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Botanical Research and Applications
- Theoretical and Computational Physics
- Edible Oils Quality and Analysis
- Genomics, phytochemicals, and oxidative stress
- advanced mathematical theories
- Mathematical Dynamics and Fractals
- Amino Acid Enzymes and Metabolism
- Microbial Metabolism and Applications
- Eicosanoids and Hypertension Pharmacology
Université de Bourgogne
2014-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024-2025
Centre National de la Recherche Scientifique
1996-2025
Centre des Sciences du Goût et de l'Alimentation
2024-2025
Institut Denis Poisson
2021-2024
Université de Tours
2021-2024
Université d'Orléans
2012-2024
Laboratoire Bio-peroxIL
2011-2023
Inserm
2009-2023
Université Bourgogne Franche-Comté
2017-2022
In recent years, research on the discovery of natural compounds with potent antioxidant properties has resulted in growing interest these due to their potential therapeutic applications oxidative-stress-related diseases. Argan oil, derived from kernels a native tree Morocco, Argania spinosa, is renowned for its rich composition bioactive compounds, prominently tocopherols, polyphenols, and fatty acids. Interestingly, large body data shown that several components argan oil activate nuclear...
Disruption of the peroxisomal acyl-CoA oxidase 1 (Acox1) gene in mouse results development severe microvesicular hepatic steatosis and sustained activation peroxisome proliferator-activated receptor-α (PPARα). These mice manifest spontaneous massive proliferation regenerating hepatocytes eventually develop hepatocellular carcinomas. Human ACOX1, first rate-limiting enzyme β-oxidation pathway, has two isoforms including ACOX1a ACOX1b, transcribed from a single gene. As shows reduced activity...
Microglia, the immune cells of central nervous system, activate neuroinflammatory pathways in response to homeostatic disturbances, a process implicated pathogenesis various neurodegenerative diseases. Emerging evidence identifies abnormal microglial activation as causal factor at onset peroxisomal leukodystrophies, including X-linked adrenoleukodystrophy (X-ALD). This study investigates how primary deficiencies influence oxidative properties microglia and examines subsequent impact on...
Sepsis causes severe dysregulation of organ functions, via the development oxidative stress and inflammation. These pathophysiological mechanisms are mimicked in mice injected with bacterial lipopolysaccharide (LPS). Here, protective properties argan oil against LPS-induced inflammation explored murine model. Mice received standard chow, supplemented (AO) or olive (OO) for 25 days, before septic shock was provoked a single intraperitoneal injection LPS, 16 hours prior to animal sacrifice. In...
Herein we report the synthesis of peptide-like and tetrazole-based organoselenium compounds via Ugi Ugi-azide reactions, respectively. The compounds' intrinsic cytoprotective antioxidant capacities were evaluated in 158 N 158JP murine oligodendrocytes. Furthermore, their redox properties theoretically using Molecular Operating Environment-docking studies. Most did not exhibit any cytotoxicity against cells. Among tested compounds, tetrazole- (e.g., 6, 7, 9) pseudopeptide-based 11, 15, 17)...
Among several peroxisomal neurodegenerative disorders, the pseudoneonatal adrenoleukodystrophy (P-NALD) is characterized by acyl-coenzyme A oxidase 1 (ACOX1) deficiency, which leads to accumulation of very-long-chain fatty acids (VLCFA) and inflammatory demyelination. However, components this process in P-NALD remain elusive. In study, we used transcriptomic profiling PCR array analyses explore gene expression patient fibroblasts. Our results show activation IL-1 pathway accompanied...
Oxidative stress and inflammation are the key players in neuroinflammation, which microglia dysfunction plays a central role. Previous studies suggest that argan oil attenuates oxidative stress, inflammation, peroxisome mouse brains. In this study, we explored effects of two major (AO) phytosterols, Schottenol (Schot) Spinasterol (Spina), on peroxisomal murine microglial BV-2 cell lines, wild-ype (Wt) Acyl-CoA oxidase 1 (Acox1)-deficient cells challenged with LPS treatment. Herein, used an...
In some neurodegenerative disorders (leukodystrophies) characterized by myelin alterations, the defect of peroxisomal functions on myelin-producing cells (oligodendrocytes) are poorly understood. The development in vitro models is fundamental to understanding physiopathogenesis these diseases. We two immortalized murine oligodendrocyte cell lines: a normal (158N) and jimpy (158JP) line mutated for proteolipid protein PLP/DM20. Fluorescence microscopy, flow cytometry, western blotting...