A5014726480- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- COVID-19 Clinical Research Studies
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Inflammatory Biomarkers in Disease Prognosis
- Inflammatory mediators and NSAID effects
- Essential Oils and Antimicrobial Activity
- Platelet Disorders and Treatments
- Inflammatory Bowel Disease
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Dermatological and COVID-19 studies
- Free Radicals and Antioxidants
- melanin and skin pigmentation
- Pharmacogenetics and Drug Metabolism
- Nanoplatforms for cancer theranostics
- Skin Protection and Aging
- Phytochemicals and Antioxidant Activities
- Ginger and Zingiberaceae research
- Cell death mechanisms and regulation
- Biological Activity of Diterpenoids and Biflavonoids
- Botanical Research and Applications
- Phytochemical compounds biological activities
Université Hassan 1er
2021-2025
University of Hassan II Casablanca
2020-2024
Université de Limoges
2011-2020
Université Internationale Abulcasis des Sciences de la Santé
2020
University of Health Sciences
2019-2020
Laboratoire National de Référence
2016
Université Mohammed VI des Sciences de la Santé
2016
Laboratoire de Chimie
2014-2015
Institut de Chimie des Substances Naturelles
2015
Centre National de la Recherche Scientifique
2013-2014
In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated thrombosis. Moreover, they can interact viruses an important source inflammatory mediators. While a lower platelet count is associated severity mortality, little known about function during COVID-19.
Arthritis, a global health burden comprising osteoarthritis and rheumatoid arthritis, demands advanced therapeutic approaches. In this context, flavonoids, diverse group of naturally occurring compounds abundant in fruits, vegetables, medicinal plants, have emerged as promising candidates for mitigating the inflammatory processes associated with arthritic conditions. This review aims, first, to provide comprehensive exploration potential focusing on specific such quercetin,...
In recent years, research on the discovery of natural compounds with potent antioxidant properties has resulted in growing interest these due to their potential therapeutic applications oxidative-stress-related diseases. Argan oil, derived from kernels a native tree Morocco, Argania spinosa, is renowned for its rich composition bioactive compounds, prominently tocopherols, polyphenols, and fatty acids. Interestingly, large body data shown that several components argan oil activate nuclear...
Skin cancer is the most widespread type of malignant tumor representing a major public health concern. Considering numerous side effects associated with conventional treatments, phytotherapy may be regarded as viable medicinal alternative. This study aimed to investigate therapeutic potential Orbea variegata (L.) Haw, an ornamental plant, in treating skin using animal model induced by combination ultraviolet (UV) irradiation and sulfuric acid treatment. The hydroethanolic extract underwent...
Ammi visnaga (A. visnaga) is an annual herb that has been used in traditional medicine to treat various ailments attributed the presence of its bioactive compounds. The purpose this study was identify and examine phytochemical properties hydroalcoholic extract A. using vitro vivo models. Our findings demonstrated contained a variety beneficial components, including phenols, flavonoids, tannins, coumarins, saponins, khellin, visnagin. total polyphenolic content flavonoid were 23.26 mg/GAE/g...
Neutrophils, the most abundant white blood cells, play a dual role in cancer progression. While they can promote tumor growth, metastasis, and immune suppression, also exhibit anti-tumorigenic properties by attacking cells enhancing responses. This review explores complex interplay between neutrophils microenvironment (TME), highlighting their ability to switch pro- anti-tumor phenotypes based on external stimuli. Pro-tumorigenic facilitate growth through mechanisms such as neutrophil...
ABSTRACT Rationale In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated thrombosis. Moreover, they can interact viruses an important source inflammatory mediators. While a lower platelet count is associated severity mortality, little known about function during COVID-19. Objective To evaluate...
Caralluma europaea is a medicinal plant used in Moroccan popular medicine, which has been employed as remedy attributed to its anti-inflammatory, antipyretic, antinociceptive, antidiabetic, neuroprotective, and antiparasitic properties. The aim of the present study was investigate antitumor activity both methanolic aqueous extract C. europaea. effects increasing concentrations extracts on human colorectal cancer HT-29 HCT116 cell lines prostate PC3 DU145 were examined proliferation using MTT...
Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing colon cancer. Their ability to modulate pivotal signaling pathways in the development progression makes them invaluable targeted therapeutics. Nevertheless, it is crucial recognize that although chalcones exhibit promise, further pre-clinical...
Increasing incidence and mortality of colorectal cancer brings the necessity to uncover new possibilities in its prevention treatment. Chalcones have been identified as interesting compounds having chemopreventive antitumor properties. In this study, we investigated effects synthetic chalcone derivative 3-hydroxy-3',4,4',5'-tetra-methoxy-chalcone (3-HTMC) on proliferation, cell cycle distribution, apoptosis, mechanism action human HT-29 (COX-2 sufficient) HCT116 deficient) cells. We showed...
In traditional medicine, Ficus carica (also known as fig) latex is recognized a remedy with various therapeutic effects. the present study we investigated antitumor activity of extracts and latex. We evaluated effects increasing concentrations on HCT-116 HT-29 human colorectal cell proliferation using MTT assay apoptosis induction by evaluating PARP cleavage Western blot analysis. Peel, pulp, leaves, whole fruit exerted significant antiproliferative (IC50 values 239, 343, 177, 299, 206...
Treatment of kidney stones is based on symptomatic medications which are associated with side effects such as gastrointestinal symptoms (e.g., nausea, vomiting) and hepatotoxicity. The search for effective plant extracts without the above has demonstrated involvement antioxidants in treatment stones. A local survey Morocco previously revealed frequent use Rubia tinctorum L. (RT) In this study, we first explored whether RT ethanolic (E-RT) ethyl acetate (EA-RT) could prevent occurrence...
Inflammatory Bowel Disease-Associated Arthritis (IBD-associated arthritis) poses a significant challenge, intertwining the complexities of both inflammatory bowel disease (IBD) and arthritis, significantly compromising patient quality life. While existing medications offer relief, these drugs often initiate adverse effects, necessitating requirement for safer therapeutic alternatives.