A5091280041- Skin Protection and Aging
- Photochemistry and Electron Transfer Studies
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Polyamine Metabolism and Applications
- Chemistry and Chemical Engineering
- Atmospheric chemistry and aerosols
- Photochromic and Fluorescence Chemistry
- Light effects on plants
- Olfactory and Sensory Function Studies
- Biochemical and biochemical processes
- Synthesis and Characterization of Heterocyclic Compounds
- Photodynamic Therapy Research Studies
- Synthesis of Organic Compounds
- Plant responses to elevated CO2
- Synthesis and Reactions of Organic Compounds
- Genomics, phytochemicals, and oxidative stress
- Algal biology and biofuel production
- Click Chemistry and Applications
- Free Radicals and Antioxidants
- Combustion and flame dynamics
- Radical Photochemical Reactions
- Transition Metal Oxide Nanomaterials
- Biochemical Analysis and Sensing Techniques
- PI3K/AKT/mTOR signaling in cancer
AgroParisTech
2020-2025
Agro-Biotechnologies Industrielles
2020-2025
AgroBio
2022-2025
Université de Limoges
2016-2021
Inserm
2019
Laboratoire de Chimie
2016
Institut de Chimie des Substances Naturelles
2016
Derivatised aurones, based on phytochemical flavonoids, were synthesized and studied using steady‐state ultrafast spectroscopy techniques. Aurones’ strong ultraviolet (UV) visible absorption, in addition to being found abundance fruits, vegetables flowers, makes them ideal photoprotection candidates for agrochemicals. Agrochemicals are well known exhibit poor photostability, the of photoprotectants their formulations thus increases longevity, thereby environmental sustainability. The results...
Food production and food security are fast becoming some of the most pressing issues 21st century. We developing environmentally responsible molecular heaters to help boost crop growth expand geographic areas capable supporting growth. Sinapic diacid (SDA) is such a molecule, that can act as light-to-heat agent, converting solar energy into heat delivered plant. have characterised photophysical properties SDA extensively, using combination steady-state ultrafast laser spectroscopy techniques...
The sparsity of efficient commercial ultraviolet-A (UV-A) filters is a major challenge toward developing effective broadband sunscreens with minimal human- and eco-toxicity. To combat this, we have designed new class Meldrum-based phenolic UV-A filters. We explore the ultrafast photodynamics coumaryl Meldrum, CMe, sinapyl Meldrum (SMe), both in an industry-standard emollient on synthetic skin mimic, using femtosecond transient electronic vibrational absorption spectroscopies computational...
Light-to-heat conversion materials generate great interest due to their widespread applications, notable exemplars being solar energy harvesting and photoprotection. Another more recently identified potential application for such is in molecular heaters agriculture, whose function protect crops from extreme cold weather extend both the growing season geographic areas capable of supporting growth, all which could help reduce food security challenges. To address this demand, a new series...
Increasing incidence and mortality of colorectal cancer brings the necessity to uncover new possibilities in its prevention treatment. Chalcones have been identified as interesting compounds having chemopreventive antitumor properties. In this study, we investigated effects synthetic chalcone derivative 3-hydroxy-3',4,4',5'-tetra-methoxy-chalcone (3-HTMC) on proliferation, cell cycle distribution, apoptosis, mechanism action human HT-29 (COX-2 sufficient) HCT116 deficient) cells. We showed...
p-Hydroxycinnamic diacids are reaction intermediates of the classical Knoevenagel–Doebner condensation between malonic acid and benzaldehydes. As they generally obtained in low yields, remain relatively under-studied under-exploited. Herein, we developed optimized a sustainable synthetic procedure allowing production these compounds good to high yields (60–80%) using proline as catalyst ethanol solvent. Study their antioxidant anti-UV activities revealed that p-hydroxycinnamic were not only...
Sinapoyl malate, naturally present in plants, has proved to be an exceptional UV filter and molecular heater for plants. Although there are nowadays industrially relevant sustainable synthetic routes sinapoyl its incorporation into certain cosmetic formulations, as well adsorption on plant leaves, is limited by hydrophilicity. To overcome these obstacles, it important find a way effectively control the hydrophilic-lipophilic balance of malate make readily compatible with formulations stick...
The recent ban of some organic UV-filters – such as oxybenzone or octinoxate considered toxic for coral reef, has heightened the need eco-friendly alternatives, especially those synthesized using green approaches that reduce carbon footprint. In this context, several thiobarbituric acid derivatives were synthetized from bio-based p-hydroxybenzaldehydes (e.g. vanillin, syringaldehyde) through a high-yielding sustainable Knoevenagel condensation, and their UV-filtering activity, stability...
In the context of designing innovative anticancer agents, synthesis a series chalcones bearing 3,4,5-trimethoxylated A ring and variety B rings, including phenols original heterocycles such as chromones, was conducted. For this end, Claisen-Schmidt condensation performed in basic or acidic conditions between common starting material 3,4,5-trimethoxyacetophenone appropriate aldehydes; allowed recovery fifteen moderate-good yields. The synthesized compounds were screened for their...
Abstract Sinapate esters have been extensively studied for their potential application in ‘nature-inspired’ photoprotection. There is general consensus that the relaxation mechanism of sinapate following photoexcitation with ultraviolet radiation mediated by geometric isomerization. This has largely inferred through indirect studies involving transient electronic absorption spectroscopy conjunction steady-state spectroscopies. However, to-date, there no direct experimental evidence tracking...
Solar exposure of avobenzone, one the most widely used commercial UVA filters on market, is known to cause significant degradation. This finding has fueled research into developing photostabilizer molecules. In an effort provide insight their stand-alone photoprotection properties, excited state dynamics photostabilizer, 3-(3,4,5-trimethoxybenzylidene) pentane-2,4-dione (TMBP), and its phenolic derivative, 3-(4-hydroxy-3,5-dimethoxybenzylidene) (DMBP), were studied with ultrafast transient...
Abstract Food security is fast becoming one of the most pressing issues 21 st century. With increasing climate instability, crop growth now routinely affected by adverse weather patterns, which can result in reduced yields and even death. We are developing an environmentally responsible molecular heater to help boost plant growth, expand geographic regions suitable for such protect plants against cold weather. Our heater, sinapic diacid (SDA, 2-(4-hydroxy-3,5-dimethoxybenzylidene)malonic...