A5031198626- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Cardiac Fibrosis and Remodeling
- Selenium in Biological Systems
- Bone Tumor Diagnosis and Treatments
- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Sarcoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Heart Rate Variability and Autonomic Control
- Melanoma and MAPK Pathways
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Cardiovascular and exercise physiology
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Eicosanoids and Hypertension Pharmacology
- Muscle Physiology and Disorders
Inserm
2014-2024
Imagerie Moléculaire et Stratégies Théranostiques
2018-2024
Clermont Université
2012-2023
Université Clermont Auvergne
2013-2023
Sorbonne Université
2001-2022
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2022
Idiap Research Institute
2020
Université Paris Cité
2002-2017
Délégation Paris 5
2002-2017
Université d'Évry Val-d'Essonne
2016-2017
Abstract Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on use vectors to deliver radionuclides tumor cells, targeting membrane‐bound cancer‐specific moieties. Here, we report embryonic navigation cue netrin‐1 as an unanticipated target vectorized radiotherapy. While netrin‐1, known be re‐expressed in tumoral cells promote cancer progression, usually characterized diffusible ligand, demonstrate here...
Acquired brain injury can lead to subtle cognitive disorders that be challenging detect albeit impacting patients' long-term functional prognosis. Cog-First has been developed as a tablet-based self-administered screening tool assess executive function, memory and attention in approximately 20 minutes, the acute phase following injury. The aim of this study was establish reliable normative data for enable meaningful comparisons between patients reference population. Cross-sectional study....
Propofol is a short-acting intravenous induction agent that induces cardiovascular depression. However, the effects of propofol on intrinsic myocardial contractility remain debatable. Thus, we studied three concentrations (1, 3, and 10 micrograms.ml-1, respectively) its solvent mechanics energetics isolated rat left ventricular papillary muscles. did not induce any significant inotropic effect as shown by lack changes in maximum unloaded shortening velocity active isometric force....
The energetics of the senescent (S) rat heart and mechanisms by which it adapts to pressure overload have been investigated simultaneous cardiac mechanical, energetic, molecular biological studies. Compared with young adult (YA), S papillary muscles had an improved economy contraction since curvature (G) Hill's (Proc. R. Soc. Lond. B. Biol. Sci. 126:136–195, 1938) hyperbola was increased (S, 1.93 +/- 0.13; YA, 1.60 0.07, P < 0.05). In addition, maximum unloaded shortening (Vmax)...
Objective: Both aging and myocardial ischemia are associated with alterations of calcium-regulating proteins. We investigated the effects graded levels low-flow on function SR Ca2+-ATPase (SERCA2), Na+-Ca2+ exchanger (NCx) ryanodine receptor (RyR2), at mRNA protein in both adult senescent myocardium. Methods: Isolated hearts from 4 24 month old (mo) rats were retrogradely perfused during 180 min 100% (100% CF, n=11 respectively), 30% (30% n=10 n=12) or 15% (15% n=13 n=8) their initial...
Although systolic left ventricular (LV) function is normal in the elderly, aging associated rat papillary muscle with mechanical and sarcoplasmic reticulum Ca 2+ ATPase alterations similar to those observed hypertrophied heart. However, other calcium-regulating proteins implicated contraction relaxation are still unknown. To investigate LV proteins, we measured hemodynamics Na + -Ca exchanger (NCx), ryanodine receptor (RyR2), reticular (SERCA2) mRNA levels (expressed densitometric scores...
Myocardial fibrosis has been investigated in 3-, 16-, and 24-mo-old normal rats also subjected to deoxycorticosterone acetate (DOCA)-salt treatment-induced-hypertension. Collagen content was assessed both histologically by hydroxyproline assay. Type I III procollagen mRNA levels were quantitated Slot Blot analyses. Aging is associated with as shown biochemically (hydroxyproline concentration 0.70 +/- 0.05, 0.92 0.07, 1.57 0.13 mg/g of left ventricle, respectively, P < 0.05 0.0001 vs. 3 mo)...
The purpose of this study was to examine the physiological characteristics an elite centenarian cyclist who, at 101 yr old, established 1-h cycling record for individuals ≥100 old (24.25 km) and determine factors associated with his performance improvement 2 later 103 (26.92 km; +11%). Before each record, he performed incremental test on a ergometer. For yr, trained 5,000 km/yr polarized training that involved 80% mileage "light" rate perceived exertion (RPE) ≤12 20% "hard" RPE ≥15 cadence...
The development of alternative therapies for melanoma treatment is great interest as long-term tumour regression not achieved with new targeted chemotherapies on selected patients. We previously demonstrated that radioiodinated heteroarylcarboxamide ([131I]ICF01012) induced a strong anti-tumoural effect by inhibiting both primary growth and dissemination process in B16BL6 model. In our study, we show single injection [131I]ICF01012 (ranging from 14.8 to 22.2 MBq) was effective associated low...
Tetraspanin 8 (TSPAN8) overexpression is correlated with poor prognosis in human colorectal cancer (CRC). A murine mAb Ts29.2 specific for TSPAN8 provided significant efficiency immunotherapy CRC pre-clinical models. We therefore evaluate the feasability of targeting radiolabeled Ts29.2. Staining tissue micro-arrays revealed that espression was restricted to a few healthy tissues. DOTA-Ts29.2 111In or 177Lu radiochemical purities >95%, activity ranging from 300 600 MBq/mg, and...
Over the last decade, upconversion nanoparticles (UCNP) have been widely investigated in nanomedicine due to their high potential as imaging agents near-infrared (NIR) optical window of biological tissues. Here, we successfully develop active targeted UCNP probes for dual NIR-NIR fluorescence and radioactive-guided surgery prostate-specific membrane antigen (PSMA)(+) prostate cancers. We designed a one-pot thermolysis synthesis method obtain oleic acid-coated spherical NaYF4:Yb,Tm@NaYF4...
The aim was to define experimental models of spontaneous arrhythmias in various cardiac hypertrophy rats.Cardiac induced by several methods and 24 h Holter monitoring recorded conscious rats quantify hypertrophied hearts. Male Wistar were studied. A group young controls 1-2 months old (n = 16) compared four groups animals with hypertrophy: (1) thyrotoxic which received a daily intraperitoneal injection L-thyroxine for 7 d 6); (2) subjected abdominal suprarenal aortic stenosis 11); (3)...
Our project deals with a multimodal approach using single fluorinated and iodinated melanin-targeting structure offering both imaging (positron emission tomography (PET)/fluorine-18) treatment (targeted radionuclide therapy/iodine-131) of melanoma. Six 6-iodoquinoxaline-2-carboxamide derivatives various side chains bearing fluorine were synthesized radiofluorinated, their in vivo biodistribution was studied by PET B16Bl6 primary melanoma-bearing mice. Among this series, [(18)F]8 emerged as...
Aim: The acetyltransferase TIP60 is reported to be downregulated in several cancers, particular breast cancer, but the molecular mechanisms resulting from its alteration are still unclear. Materials & methods: In tumors, H3K4ac enrichment and link with were evaluated by chromatin immunoprecipitation-qPCR re-chromatin immunoprecipitation techniques. To assess biological roles of two cell lines MDA-MB-231 (ER-) MCF-7 (ER+) transfected shRNA specifically targeting injected athymic Balb-c mice....
This work aims to study the regulation of glutathione peroxidase and catalase activities in myoblasts from L6 line exposed 21%, 5% 1% O2 during cell differentiation.Rat were grown 1%, or 21% presence absence N-acetyl cysteine. The proliferation was evaluated by determining doubling time kinetics cultures counting cells. differentiation analyzed myogenic fusion index using antibodies against myosin heavy chain. assayed. p110-PI3K/Thr308-Akt pathway studied western blotting. oxidative status...