A5073610472- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Cardiac Imaging and Diagnostics
- Orthopedic Infections and Treatments
- Medical Imaging and Pathology Studies
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Thyroid Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Ovarian cancer diagnosis and treatment
- Advanced X-ray and CT Imaging
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- HER2/EGFR in Cancer Research
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Total Knee Arthroplasty Outcomes
Centre Jean Perrin
2015-2024
Inserm
2014-2024
Imagerie Moléculaire et Stratégies Théranostiques
2015-2024
Université Clermont Auvergne
2012-2023
Sigma Clermont
2022
Centre Cardiologique du Nord
2019
Institut de Cancérologie de l'Ouest
2013
Institut de Cancérologie de Lorraine
2013
Institut Curie
2013
Institut Jean Godinot
2013
Purpose This study examines the use of [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) for evaluation therapeutic response patients treated with high-dose chemotherapy (HDC) autologous stem cell transplantation metastatic breast cancer (MBC) focusing on prognostic stratification. Patients and Methods Forty-seven MBC were a maximum three cycles HDC. Therapeutic was assessed conventional imaging (CImg; including computed in all cases ultrasound, mammography, bone scanning as...
As the preparation phase of a multicenter clinical trial using (18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG), (18)F-fluoromisonidazole ((18)F-FMISO), and 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) in non-small cell lung cancer (NSCLC) patients, we investigated whether 18 nuclear medicine centers would score tracer uptake intensity similarly define hypoxic proliferative volumes for 1 patient compared different segmentation methods. Ten (18)F-FDG, ten (18)F-FMISO, (18)F-FLT PET/CT examinations...
Despite its good prognosis, differentiated thyroid cancer (DTC) is characterized by high rates of disease persistence and recurrence. Estimation long-term remission (excellent response) thanks to specific parameters could help individualize the active surveillance schedule.Evaluation ability stimulated thyroglobulin (Tg) Tg reduction index (TRI) predict in patients with DTC managed thyroidectomy radioactive iodine (RAI) remnant ablation.Observational retrospective study 1093 treated for...
Our group has developed a new radiopharmaceutical, <sup>123</sup>I<b>-</b><i>N</i>-(2-diethylaminoethyl)-2-iodobenzamide (<sup>123</sup>I-BZA2), benzamide derivative able to bind melanin pigment in melanoma cells. In prospective and multicentric phase III clinical study, the value of <sup>18</sup>F-FDG PET/CT <sup>123</sup>I-BZA2 scintigraphy was compared for staging. <b>Methods:</b> Patients with past history cutaneous or ocular were included from 8 hospitals. imaging performed according...
Introduction Differentiated thyroid cancer (DTC) is the most common of endocrine cancers. Many studies have focused on recurrence-free survival DTC patients, however, few addressed overall rates. Given its very good prognosis, estimating or long-term in patients with seems rational. So far, neither impact pre- and post-ablation thyroglobulin, nor that initial American Thyroid Association (ATA) risk stratification disease-specific survival, been sufficiently studied. Objective The aim this...
Introduction: The aim of this study was to find the best ordered combination two FDG positive musculoskeletal sites with a machine learning algorithm diagnose polymyalgia rheumatica (PMR) vs. other rheumatisms in cohort patients inflammatory rheumatisms. Methods: This retrospective included 140 who underwent [ 18 F]FDG PET-CT and whose final diagnosis rheumatism. randomized, stratified on into training validation cohort. uptake 17 evaluated visually set if at least equal that liver. A...
We examined the relevance of a pre-treatment single static view 99mTc-sestamibi scintimammography and expression multidrug resistance proteins as predictors response to neoadjuvant chemotherapy for invasive breast cancer. Forty-five patients affected by primary cancer underwent clinical examination, mammography, sonography, scintimammography, biopsy histopathological diagnosis before chemotherapy. Expression MDR1 MRP mRNA were determined RT-PCR on fine-needle aspirations. Following...
(1) Background: As outcome of patients with metastatic melanoma treated anti-PD1 immunotherapy can vary in success, predictors are needed. We aimed to predict at the patients' levels, overall survival (OS) and progression-free (PFS) after one year immunotherapy, based on their pre-treatment 18F-FDG PET; (2) Methods: Fifty-six patients-without prior systemic treatment-were retrospectively included. Forty-five PET-based radiomic features were computed top five associated patient's selected....
Purpose Differentiating brain metastasis recurrence from radiation necrosis can be challenging during MRI follow-up after stereotactic radiotherapy. [ 18 F]-FDG is the most available PET tracer, but standard images performed 30 to 60 minutes postinjection provide insufficient accuracy. We compared diagnostic performance and interobserver agreement of with delayed (4–5 hours postinjection) ones provided by dual-time-point imaging. Methods Consecutive patients referred for inconclusive were...
The GATE Monte Carlo simulation platform based on the Geant4 toolkit is under constant improvement for dosimetric calculations. In this study, we explore its use dosimetry of preclinical targeted radiotherapy melanoma using a new specific melanin-targeting radiotracer labeled with iodine 131. Calculated absorbed fractions and S values spheres murine models (digital CT-scan-based mouse phantoms) are compared between EGSnrc codes considering monoenergetic electrons detailed energy spectrum...
Melanin-targeting radiotracers are interesting tools for imaging and treatment of pigmented melanoma metastases. However, variation the pigment concentration may alter efficiency such targeting. A clear assessment both tumor melanin status dosimetry therefore prerequisites internal radiotherapy disseminated melanoma. The tracer ICF01012 was labelled with iodine-123 in murine B16F0 human SK-Mel 3 melanomas. In vivo showed that uptake [(123)I]ICF01012 to melanomas correlated significantly...
Our aim was to analyse whether biomarkers extracted from baseline 18F-FDG PET before anti-PD1 treatment contribute prognostic survival information for early risk stratification in metastatic melanoma. Fifty-six patients, without prior systemic treatment, BRAF wild type, explored using were included retrospectively. primary endpoint overall (OS). Total metabolic tumoral volume (MTV) and forty-one IBSI compliant parameters PET. Parameters associated with outcome evaluated by a cox regression...