A5068537810- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Alzheimer's disease research and treatments
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Surgical Treatments
Hôpital Saint-Louis
2016-2024
Université de Rennes
2014-2023
Centre Eugène Marquis
2014-2023
Sorbonne Université
2017-2023
Assistance Publique – Hôpitaux de Paris
2013-2023
Pitié-Salpêtrière Hospital
2018-2023
Laboratoire Traitement du Signal et de l'Image
2021-2023
Centre Hospitalier Guillaume Régnier
2012-2021
Université de Lille
2018-2021
Inserm
2018-2021
The treatment of metastatic neuroendocrine tumors depends on the aggressiveness disease. We wanted to know whether <sup>18</sup>F-FDG PET and somatostatin receptor scintigraphy (SRS) can predict early disease progression patient survival. <b>Methods:</b> undertook a prospective study patients with tumor diagnosed between September 2003 January 2006. After obtaining signed informed consent from patients, we performed CT, SRS, reviewed histologic data. CT was repeated every 3 mo assess risk...
Apathy may be induced by subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease (PD). We therefore wished to test the hypothesis that apathy STN-DBS correlates with changes glucose metabolism, using (18)FDG-PET.Twelve patients PD were assessed 3 months before (M-3) and after (M+3) (18)FDG-PET Evaluation Scale.Apathy had significantly worsened at M+3 STN-DBS. Positive correlations observed between this variation scores especially right frontal middle gyrus (Brodmann area...
Abstract This pilot study was designed to assess the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) over right orbitofrontal cortex (OFC) by means a double-cone coil in patients suffering from obsessive-compulsive disorder. We hypothesized that OFC would lead reduction clinical symptoms, as measured on Yale-Brown Obsessive Compulsive Scale (Y-BOCS). A randomized, double-blind, crossover design implemented with two 1-week treatment periods (active versus sham...
Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and a recent study, we found fear recognition be impaired result. These changes have been attributed disturbance STN's limbic territory would appear confirm that negative emotion network passes through STN. In addition, it now widely acknowledged damage orbitofrontal cortex (OFC), especially right side, can result facial emotions...
We sought to identify apathy metabolic bases in Parkinson disease (PD).A total of 45 patients with PD who were not clinically depressed (Montgomery-Åsberg Depression Rating Scale [MADRS] <21) and had no dementia (Mattis Dementia [MDRS] >130) assessed the Apathy Evaluation (AES) underwent a resting-state F-18 fluorodeoxyglucose PET (FDG-PET) scan. A motor assessment comprising Unified Parkinson's Disease Part III (UPDRS-III) was conducted levodopa equivalent daily dose (LEDD) calculated....
Objective: The aim of the study was to assess relevance resection margin status for survival after pancreatic-head ductal adenocarcinoma. Summary Background Data: definition and prognostic value incomplete microscopic (R1) remain controversial. Methods: Prognostic factors were analyzed in 147 patients included a prospective multicenter on impact tumor clearance evaluated using standardized pathology protocol. Results: Thirty received neoadjuvant treatment (NAT = 20%); 41 had venous (VR 28%),...
Apathy is a disabling non-motor symptom that frequently observed in Parkinson9s disease (PD). Its description and physiopathology suggest it partially mediated by emotional impairment, but this research issue has never been addressed at clinical metabolic level. We therefore conducted study using <sup>18</sup>fluorodeoxyglucose positron emission tomography (<sup>18</sup>FDG PET) 36 PD patients without depression dementia. was assessed on the Evaluation Scale (AES), facial recognition (EFR)...
Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) can produce emotional disorders that have been linked to disturbance of the STN's limbic territory. The aim this study was confirm impairment recognition facial emotions (RFE) induced by STN DBS, not only ruling out effect disease's natural progression relation but also assessing influence modifications dopamine replacement therapy (DRT) following DBS. RFE investigated 24 PD patients who underwent...
High-frequency deep brain stimulation (DBS) represents a major stake for treatment treatment-resistant depression (TRD). We describe preliminary trial of DBS two potential targets in chronic TRD: the nucleus accumbens (Acb) and, event failure, caudate nucleus. Patients were followed 6 months before surgery (M0). From M1 to M5, they underwent Acb target. PET scans allowed us track metabolic modifications resulting from this stimulation. The target nonresponders was stimulated between M5 and...
<h3>Objective:</h3> The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, no information about cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. <h3>Methods:</h3> To resolve this issue, we set out to identify factors increased STN-DBS. Forty-four patients disease were enrolled study. They all underwent Metabolic activity was assessed F-18...
There appears to be an overlap between the limbic system, which is modulated by subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD), and network that mediates theory of mind (ToM). Accordingly, aim present study was investigate effects STN DBS on ToM PD patients correlate modifications with changes glucose metabolism.To this end, we conducted (18)FDG-PET scans 13 pre- post-STN conditions correlated their metabolism modified performances Eyes test, a visual task...
To test for cerebellar involvement in motor and nonmotor impairments Parkinson disease (PD) to determine patterns of metabolic correlations with supratentorial brain structures, we correlated clinical motor, cognitive, psychiatric scales metabolism.We included 90 patients PD. Motor, domains were assessed, resting-state 18FDG-PET imaging was performed. The scores entered separately into a principal component analysis. We looked between these 3 components metabolism. Furthermore, extracted the...
Background Deep brain stimulation has shed new light on the central role of prefrontal cortex (PFC) in obsessive compulsive disorder (OCD). We explored this structure from a functional perspective, synchronizing neuroimaging and cognitive measures. Methods Findings This case-control cross-sectional study compared 15 OCD patients without comorbidities not currently serotonin reuptake inhibitors or behavioural therapy with healthy controls (matched for age, sex education level) resting-state...