Tiphaine Rouaud
A5014364877- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Functional Brain Connectivity Studies
- Ginkgo biloba and Cashew Applications
- Gastrointestinal motility and disorders
- Autism Spectrum Disorder Research
- Cerebrovascular and genetic disorders
- Thyroid and Parathyroid Surgery
- Medical Imaging and Pathology Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Lysosomal Storage Disorders Research
- Electroconvulsive Therapy Studies
- Amyotrophic Lateral Sclerosis Research
- Cellular transport and secretion
- Advanced Neuroimaging Techniques and Applications
- Pharmaceutical industry and healthcare
- Metalloenzymes and iron-sulfur proteins
- Neurogenetic and Muscular Disorders Research
Nantes Université
2011-2025
French Clinical Research Infrastructure Network
2021-2025
Centre Hospitalier Universitaire de Nantes
2012-2024
Inserm
2011-2024
Centre d'Investigation Clinique de Nantes
2013-2023
Hôpital Laennec
2016-2022
Centre Hospitalier Universitaire de Reims
2017
Centre National de la Recherche Scientifique
2017
Hôpital Maison Blanche
2017
Université d'Angers
2017
Deep brain stimulation (DBS) is a reversible technique that currently used for the treatment of Parkinson disease and may be suitable psychiatric disorders. Whether DBS inactivates target structure still matter debate. Here, from findings obtained in rats, we propose subthalamic nucleus (STN) as possible cocaine addiction to further tested human studies. We show STN reversibly reduces motivation work an i.v. injection cocaine, it increases sucrose pellets. These opposite effects result...
<h3>Objective:</h3> To confirm the efficacy and safety of deep brain stimulation (DBS) internal part globus pallidus in improving severe tardive dyskinesia (TD). <h3>Methods:</h3> Nineteen patients with pharmacoresistant TD were included. All assessed at baseline 3, 6 (main outcome measure), 12 months, long term (6–11 years) for 14 patients, after bilateral pallidal DBS, using motor scales (Extrapyramidal Symptoms Rating Scale [ESRS], Abnormal Involuntary Movement [AIMS]), cognitive scales,...
Primary familial brain calcification (PFBC) is a rare neurogenetic disorder with diverse neuropsychiatric expression. Mutations in four genes cause autosomal dominant PFBC: SLC20A2, XPR1, PDGFB and PDGFRB. Recently, biallelic mutations the MYORG gene have been reported to PFBC an recessive pattern of inheritance. We screened 29 unrelated probands negatively for identified 11 families or novel predicted damaging variant. studied clinical radiological features 16 patients these compared them...
ABSTRACT Background Impact of subthalamic deep brain stimulation (DBS) on impulse control disorders (ICD) in Parkinson's disease (PD) remains controversial. Objectives The objectives this study were to analyze the natural history ICD between baseline and 1 year after DBS patients with PD identify predictive factors, taking into account positions active contact parameters. Methods We analyzed postoperative modifications based multicentric, prospective Predictive Factors Subthalamic...
Abstract Postoperative apathy is a frequent symptom in Parkinson’s disease patients who have undergone bilateral deep brain stimulation of the subthalamic nucleus. Two main hypotheses for postoperative been suggested: (i) dopaminergic withdrawal syndrome relative to drug tapering; and (ii) direct effect chronic The primary objective our study was describe preoperative 1-year underwent We also aimed identify factors associated with considering: clinical phenotype; management; (iii) volume...
Abstract Background Among the different types of pain related to Parkinson's disease (PD), parkinsonian central (PCP) is most disabling. Objectives We investigated analgesic efficacy two therapeutic strategies (opioid with oxycodone‐ prolonged‐release (PR) and higher dose levodopa/benserazide) compared placebo in patients PCP. Methods OXYDOPA was a randomized, double‐blind, double‐dummy, placebo‐controlled, multicenter parallel‐group trial run at 15 centers within French NS‐Park network. PD...
There appears to be an overlap between the limbic system, which is modulated by subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD), and network that mediates theory of mind (ToM). Accordingly, aim present study was investigate effects STN DBS on ToM PD patients correlate modifications with changes glucose metabolism.To this end, we conducted (18)FDG-PET scans 13 pre- post-STN conditions correlated their metabolism modified performances Eyes test, a visual task...
Abstract To compare body mass index (BMI) and daily energy intake (DEI) after subthalamic versus pallidal deep brain stimulation (DBS). Weight gain following DBS in Parkinson's disease patients remains largely unexplained no comparison of (GPi) has yet been performed. BMI DEI, dopaminergic drug administration motor scores were recorded 46 with PD before STN (n = 32) or GPi 14) 3 6 months after. At M6, had increased by an average 8.4% the group 3.2% group. 28 9 patients. This increase was...
Abstract The aim of this study was to evaluate the efficacy and safety bilateral pallidal (GPi) deep brain stimulation (DBS) 6 months after surgery in advanced parkinsonian patients whose dopa‐resistant axial motor signs or cognitive decline constituted contraindications for subthalamic nucleus (STN) DBS. Seventeen with a mean age 59.3 ± 7.1 years (range, 45–70), disease duration 12.5 4.3 7–20), STN DBS, underwent GPi They were evaluated before afterward, accordance Core Assessment Program...
Speech impairment is a recognized but unpredictable adverse effect of sub-thalamic nucleus deep brain stimulation (STN-DBS) for Parkinson's disease (PD). To evaluate the prevalence speech 1 year after STN-DBS in PD patients and to determine predictive factors outcome following STN-DBS. Data 417 from French national PREDISTIM study were collected preoperatively. The combined medical treatment surgery on was compared using specific items dedicated clinical scales (MDS-UPDRS III.1: primary...