Lucie Hopes
A5066265403- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Autoimmune Neurological Disorders and Treatments
- Epilepsy research and treatment
- Genetic Neurodegenerative Diseases
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Long-Term Effects of COVID-19
- Botulinum Toxin and Related Neurological Disorders
- Dementia and Cognitive Impairment Research
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Intensive Care Unit Cognitive Disorders
- Neurological and metabolic disorders
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Cerebrospinal fluid and hydrocephalus
- Pharmacological Receptor Mechanisms and Effects
- Voice and Speech Disorders
- DNA Repair Mechanisms
- Child Abuse and Trauma
- interferon and immune responses
Centre Hospitalier Régional et Universitaire de Nancy
2016-2025
Université de Lorraine
2019-2024
Inserm
2016-2024
Université Claude Bernard Lyon 1
2024
Centre National de la Recherche Scientifique
2024
Research Network (United States)
2024
French Clinical Research Infrastructure Network
2024
Université de Bordeaux
2024
Université Clermont Auvergne
2021
Hôpital Roger Salengro
2018
Aims: The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a chelation strategy aimed at reducing oxidative damage associated with regional deposition without affecting circulating metals. Translational cell and animal models provided concept proofs delayed-start (DS) treatment paradigm, the basis for preliminary clinical assessments. Results: For translational studies, we effect insults mice systemically prechelated deferiprone (DFP) following motor functions,...
BackgroundLixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment of diabetes, has shown neuroprotective properties in mouse model Parkinson's disease.MethodsIn this phase 2, double-blind, randomized, placebo-controlled trial, we assessed effect lixisenatide on progression motor disability persons with disease. Participants whom disease was diagnosed less than 3 years earlier, who were receiving stable dose medications to treat symptoms, and did not have complications...
<h3>Background and Objectives</h3> To report the clinical, biological, imaging features clinical course of a French cohort patients with glial fibrillary acidic protein (GFAP) autoantibodies. <h3>Methods</h3> We retrospectively included all who tested positive for GFAP antibodies in CSF by immunohistochemistry confirmed cell-based assay using cells expressing human GFAPα since 2017 from 2 referral centers. <h3>Results</h3> identified 46 antibodies. Median age at onset was 43 years, 65% were...
While patients with paraneoplastic autoimmune encephalitis (AE) gamma-aminobutyric-acid B receptor antibodies (GABA
Introduction Magnetic resonance imaging (MRI) can be used to identify biomarkers in Parkinson's disease (PD); R2* values reflect iron content related high levels of oxidative stress, whereas volume and/or shape changes neuronal death. We sought assess overload the nigrostriatal system and characterize its relationship with focal overall atrophy striatum pivotal stages PD. Methods Twenty controls 70 PD patients at different (untreated de novo patients, treated early-stage advanced-stage...
Small-cell lung cancer (SCLC) is the malignancy most frequently associated with paraneoplastic neurological syndromes (PNS) and can trigger different antibody responses against intracellular (Hu) or neuronal surface (GABAB R) antigens. Our aim was to clarify whether genomic transcriptomic features of SCLC are in patients anti-GABAB R anti-Hu PNS compared without PNS. A total 76 tumor samples were collected: 34 anti-Hu, 14 R, 28 The study consisted 4 steps: (1) pathological confirmation; (2)...
Abstract Background Recent studies have confirmed the presence of cognitive disorders, which may be maintained over long term and associated with psychological disorders following COVID-19 infection. The aim our study was to characterize long-term psychiatric in patients younger than 65 years hospitalized for severe Methods All who were between October 2020 July 2021 infection a complaint according QPC questionnaire selected. They underwent systematic neuropsychological evaluation assessing...
Speech impairment is a recognized but unpredictable adverse effect of sub-thalamic nucleus deep brain stimulation (STN-DBS) for Parkinson's disease (PD). To evaluate the prevalence speech 1 year after STN-DBS in PD patients and to determine predictive factors outcome following STN-DBS. Data 417 from French national PREDISTIM study were collected preoperatively. The combined medical treatment surgery on was compared using specific items dedicated clinical scales (MDS-UPDRS III.1: primary...
Abstract Background and purpose Our objective was to define phenotypes of non‐lesional late‐onset epilepsy (NLLOE) depending on its presumed aetiology determine their seizure cognitive outcomes at 12 months. Methods In all, 146 newly diagnosed NLLOE patients, >50 years old, were prospectively included categorized by four aetiological subtypes: neurodegenerative subtype (patients with a diagnosis disease) ( n = 31), microvascular three or more cardiovascular risk factors two vascular...
Epilepsy seems to be an important comorbidity in patients with early onset Alzheimer's disease (EOAD). Currently, seizures are still underestimated this population. However, may interact AD evolution possible acceleration of cognitive decline.To better define the epileptic disorders observed EOAD.All diagnosed as EOAD our hospital between 2013 and 2019 positive CSF biomarkers for were selected. The usual follow-up was extended a 3-h EEG consultation epilepsy expert. Information on collected...
NMF are currently poorly evaluated in therapeutic decisions. A quantification of their severity would facilitate integration. The objective this study was to validate an autoquestionnaire evaluating the non-motor fluctuations (NMF) Parkinson's disease (PD).
To delineate common epilepsy features associated with the presence of glutamic acid decarboxylase autoantibodies (GAD65-Ab).Three consecutive cases GAD65-Ab encephalitis patients, followed in our neurological department, were investigated regards to clinical semiology and EEG.These patients presented new-onset subtle ictal features. Patients 1 2 described prolonged transitory feelings "déjà vu - déjà vécu" a "dreamy state". Patient 3 was admitted for subsequent transient aphasia events by...
The aim of this study was to assess, in routine, the rates with which an amyloid deposition documented by 18F-florbetaben PET patients suspected Alzheimer's disease (AD) but isolated increases cerebrospinal fluid (CSF) tau-protein concentrations, and subsequent impact these results on medical management.This prospective included 34 mild neurocognitive disorders (MND) AD (73±9 years, 16 women) abnormal CSF concentrations total-tau (T-tau) and/or phosphorylated-tau (P-tau) proteins normal Aβ42...
To determine whether patients with Parkinson disease (PD) eligible for subthalamic nucleus deep brain stimulation (STN-DBS) probable REM sleep behavior disorder (RBD) preoperatively could be more at risk of poorer motor, nonmotor, and quality life outcomes 12 months after surgery compared to those without RBD. We analyzed the preoperative clinical profile 448 PD from a French multicentric prospective study (PREDISTIM) according presence or absence RBD based on Single Question Screening...
Background: Dopamine responsiveness (dopa-sensitivity) is an important parameter in the management of patients with Parkinson’s disease (PD). For quantification this parameter, undergo a challenge test acute Levodopa administration after drug withdrawal, which may lead to patient discomfort and use significant resources. Objective: Our objective was develop predictive model combining clinical scores imaging. Methods: 350 patients, recruited by 13 specialist French centers considered for deep...