C. Simonin
A5090976215- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Cellular transport and secretion
- Pluripotent Stem Cells Research
- DNA Repair Mechanisms
- Employment and Welfare Studies
- Hereditary Neurological Disorders
- Autism Spectrum Disorder Research
- Infectious Encephalopathies and Encephalitis
- Transcranial Magnetic Stimulation Studies
- CRISPR and Genetic Engineering
- Healthcare Systems and Practices
- Workplace Health and Well-being
- Systemic Lupus Erythematosus Research
- Retinal Development and Disorders
- Restraint-Related Deaths
- Geotechnical Engineering and Underground Structures
- IgG4-Related and Inflammatory Diseases
- Medical and Health Sciences Research
- Sarcoidosis and Beryllium Toxicity Research
- Neurological diseases and metabolism
- Peripheral Neuropathies and Disorders
Université de Lille
2010-2024
Centre Hospitalier Universitaire de Lille
2015-2024
Lille Neurosciences & Cognition
2021-2024
Inserm
2014-2024
Centre de Recherche Jean Pierre Aubert
2011-2023
Kantonsspital St. Gallen
2019
Institut Sainte Catherine
2019
Hospices Civils de Lyon
2013-2018
Hôpital Roger Salengro
2007-2018
Hôpital Pierre Wertheimer
2018
Background: Long-term trends of the incidence and outcome cardiogenic shock (CS) patients are scarce. We analyze for first time in CS during a 20-year period Switzerland. Methods Results: The AMIS (Acute Myocardial Infarction Switzerland) Plus Registry enrolls with acute myocardial infarction from 83 hospitals analyzed incidence, treatment, in-hospital mortality enrolled between 1997 2017. impact revascularization strategy on was assessed 2005 to Among 52 808 enrolled, 963 were excluded...
Expression or phosphorylation levels of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have strong potential as disease pharmacodynamic biomarkers. The main objective this study is therefore to assess the LRRK2-Rab pathway for use biomarkers in human, non-human primate (NHP) rat urine. With urine collected from human subjects animals, we applied an ultracentrifugation based fractionation protocol isolate small urinary extracellular vesicles (uEVs). We used western blot with...
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a preferred treatment for parkinsonian patients with severe motor fluctuations. Proper targeting STN sensorimotor segment appears to be crucial factor success procedure. The recent introduction directional leads theoretically increases specificity in this challenging area but also requires more precise parameters. Objective: We investigated whether commercially available software image guided programming (IGP) could...
Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients Huntington's disease (HD). Five were compared a control group on and off states stimulator. External decreased neuronal activity modulated cerebral connectivity within basal ganglia-thalamocortical circuitry, sensorimotor, default-mode networks. These data indicate that GPe modulates functional integration...
<b>Objective:</b> The somatotropic axis (growth hormone [GH] and insulinlike growth factor I [IGFI]) play a role in the cognitive deficits seen with aging, GH deficiency, neurodegenerative disorders such as Alzheimer disease. We recently reported elevations basal plasma IGFI levels patients Huntington disease (HD). Here, our objective was to determine whether abnormalities predicted dysfunction HD. <b>Methods:</b> In this prospective cohort study of 109 genetically documented HD, aged 21 85...
Background: Cysteamine has been demonstrated as potentially effective in numerous animal models of Huntington's disease. Methods: Ninety-six patients with early-stage disease were randomized to 1200 mg delayed-release cysteamine bitartrate or placebo daily for 18 months. The primary end point was the change from baseline UHDRS Total Motor Score. A linear mixed-effects model repeated measures used assess treatment effect, expressed least-squares mean difference minus placebo, negative values...
Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson's disease (PD), and orally bioavailable, brain penetrant highly potent LRRK2 inhibitors are in early stages clinical testing. Detection phosphorylation, as well phosphorylation Rab10, substrate, have been proposed engagement biomarkers inhibitor trials. However, these readouts do not seem able to stratify patients based on enhanced activity. Here, we describe robust cell biological assay...
Background: Obstetrical analgesia remains a matter of controversy because the fear neurotoxicity local anesthetics on demyelinated fibers or their potential relationship with subsequent relapses. Objective: To assess impact neuraxial risk relapse during first 3 months post-partum, focus women who experienced relapses pregnancy. Methods: We analyzed data followed-up prospectively pregnancies and at least collected in Pregnancy Multiple Sclerosis (PRIMS) Prevention Post-Partum Relapses...
Little is known about the genetic factors modulating progression of Huntington's disease (HD). Dopamine levels are affected in HD and modulate executive functions, main cognitive disorder HD. We investigated whether Val158Met polymorphism catechol-O-methyltransferase (COMT) gene, which influences dopamine (DA) degradation, affects clinical carried out a prospective longitudinal multicenter study from 1994 to 2011, on 438 gene carriers at different stages (34 pre-manifest; 172 stage 1; 130 2;...
Purpose: Huntington's disease is a rare condition. Patients are commonly treated with antipsychotics and tetrabenazine. The evidence of their effect on progression limited no comparative study between these drugs has been conducted. We therefore compared the effectiveness progression. Methods: 956 patients from Huntington French Speaking Group were followed for up to 8 years 2002 2010. treatments was assessed using Unified Disease Rating Scale (UHDRS) scores then mixed model adjusted...
Background and purpose In cervical dystonia, the accuracy of botulinum neurotoxin (BoNT) injections may influence response to treatment. Methods We used ultrasound evaluate anatomy‐guided BoNT in neck muscles. Results A total 56 consecutive patients 332 were evaluated. The overall was 76.6%. lowest (67.9%) observed for splenius capitis muscle. Conclusions Anatomic guidance muscles is often inaccurate. Imaging improve dystonia.
Background There is an urgent need to assess and improve the consent process in clinical trials of innovative therapies for neurodegenerative disorders. Methods We performed a longitudinal study Huntington's disease patients during Multicenter Fetal Cell Intracerebral Grafting Trial Disease (MIG-HD) France Belgium. Patients their proxies completed questionnaire at inclusion, before signing form after one year follow-up, randomization transplantation. The explored understanding protocol,...