A5038589428- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Pathology Studies
- Fluorine in Organic Chemistry
- Synthesis of β-Lactam Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Catalytic Reactions
- Prostate Cancer Diagnosis and Treatment
- Synthesis and Biological Evaluation
- Cardiac Structural Anomalies and Repair
- Lanthanide and Transition Metal Complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Synthesis of heterocyclic compounds
- Pancreatic and Hepatic Oncology Research
- Neurological disorders and treatments
- Inhalation and Respiratory Drug Delivery
- Genetic Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
- TGF-β signaling in diseases
- Pharmaceutical studies and practices
- Occupational exposure and asthma
- Synthesis and Reactivity of Sulfur-Containing Compounds
Université Libre de Bruxelles
2011-2023
Erasmus Hospital
2010-2023
VIB-UAntwerp Center for Molecular Neurology
2013
UCLouvain
1996-2004
ParisTech
2000
Institut Bouisson Bertrand
1987
Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due mutations in the receptors and/or downstream signaling molecules. influences CRC only indirectly via stromal cells, such as cancer-associated fibroblasts. However, cell ability directly respond currently remains unexplored. This represents a missed opportunity for diagnostic and therapeutic interventions. Methods: We examined whether from primary liver metastases by inducing TGFβ-induced protein ig-h3 (TGFBI)...
Idiopathic pulmonary fibrosis is characterized by a progressive and irreversible respiratory failure. Validated noninvasive methods able to assess disease activity are essential for prognostic purposes as well the evaluation of emerging antifibrotic treatments.C57BL/6 mice were used in murine model induced an intratracheal instillation bleomycin (control instilled with saline solution). At different times after instillation, PET/CT (18)F-FDG- or (18)F-4-fluorobenzamido-N-ethylamino-maleimide...
Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and irreversible respiratory failure. Non-invasive markers of disease activity are essential for prognosis evaluation early response to anti-fibrotic treatments.The aims this study were determine whether fluorodeoxyglucose ([18F]-FDG) lung uptake reduced after initiation pirfenidone or nintedanib assess its possible use as prognostic factor.[18F]-FDG PET/CT was performed in IPF patients murine model fibrosis. PET/CTs at...
Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients Huntington's disease (HD). Five were compared a control group on and off states stimulator. External decreased neuronal activity modulated cerebral connectivity within basal ganglia-thalamocortical circuitry, sensorimotor, default-mode networks. These data indicate that GPe modulates functional integration...
Preoperative molecular imaging is paramount to direct surgery in primary hyperparathyroidism (pHPT). We investigated the diagnostic performance of 18F-fluorocholine (18F-FCH) PET/CT compared with 11C-methionine (11C-MET) for localization hyperfunctioning parathyroid tissue patients pHPT and negative or inconclusive 99mTc-sestaMIBI (99mTc-MIBI) SPECT findings. Methods: Fifty-eight biochemical evidence 99mTc-MIBI findings were referred presurgical detection by 11C-MET 18F-FCH PET/CT. The...
Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised PET/CT imaging. We evaluated whether the measurement FAPα in bronchoalveolar lavage fluids (BALF) uptake FAPI could used as biomarkers fibrogenesis.The dynamics lung 18F-labeled ([18F]FAPI-74) was assessed bleomycin mouse model at various time points using different concentrations PET/CT. measured BALFs from these bleomycin-treated control mice....
We evaluated the diagnostic performance of (18)F-FDG PET/CT and MRI for assessment head neck squamous cell carcinoma (HNSCC) relapse. Since early treatment might prevent inoperable relapse, we also THE unenhanced in residual tumor detection. The study was prospectively performed on 32 patients who underwent before at 4 12 months after treatment. 2 weeks end radiotherapy. Histopathology or a minimum 18 follow-up were used as gold standard. Before detected all primary tumors except two limited...
Digital PET/CT systems make use of a new technology with higher sensitivity and other better technological features than the analog ones. They require adaptation trade-off between performance, tracer dose acquisition time. The aim study was to explore performance 18F-JK-PSMA-7 imaging when performed on digital an adapted protocol, in population patients prostate cancer (PCa). Influence previous therapy is generally disregarded PSMA-based imaging, despite potential influence...
We used [ 18 F]‐4‐fluorobenzamido‐ N ‐ethylamino‐maleimide ([ F]‐FBEM) to radiolabel cells ex vivo for in positron emission tomography (PET) order assess cell trafficking mice. In contrast commonly imaging agents, F]‐FBEM forms a covalent bond with thiol groups present on the surface. The stability of probe aqueous medium was tested at different pH values and cross‐experiment showed that thiol‐labeling efficiency retained (at least) up 9. labeling procedure did not affect significantly...
Summary The interactions between a typical range of perfume materials, alcohol, water, air, elevated temperatures and daylight have been studied. changes composition, acidity, peroxide content the formation new molecules were followed. stabilizing effects UV absorbers, antioxidants sequestering agents examined; - acid reaction products was accelerated by temperature, presence natural products; heat light air; as acidity increased, peroxides decomposed; acetalization other aldehydes...
Although local therapy for prostate cancer (PCa) is curative some patients, 27–53% develop a biochemical recurrence (BCR), which defined by rise in serum prostate-specific antigen (PSA) le...
Positron emission tomography/computed tomography (PET/CT) using radiotracers that bind to the prostate-specific membrane antigen (PSMA) is mainly used in biochemical recurring prostate cancer. The aim of our study was assess usefulness 18F-JK-PSMA-7 PET/CT for local and nodal staging patients with intermediate- high-risk cancer (PCa) prior radical prostatectomy, as compared conventional imaging techniques.We enrolled a total 10 PCa diagnosed by multiparametric-MRI followed systematic...
ω-Aminodithioester derivatives were obtained from thionolactams by reaction with an alkyl triflate followed thiolysis hydrogen sulfide. The presence of electron-withdrawing group was required on the N1 position (p-nitrophenyl or benzoyl) to favor ring opening γ-, δ- and ε-thionolactams. In case β-thionolactam, activation provided a CF2 motif in C3
The behavior of trichloroacylhydrazones as new highly reactive alkylating agents is disclosed; various secondary amines are alkylated within a few minutes at room temperature, and similar reductions were found with malonates.
Representative N-protected 3,3-difluoroazetidin-2-ones 3 were obtained, either in one step by cycloaddition of zinc enolate 1 derived from ethyl bromodifluoroacetate onto N,N′,N′′-trisubstituted hexahydro-1,3,5-triazines 2 (Schiff base trimer) the case 3a [N-(p-methoxybenzyl) derivative], or two steps consisting a Reformatsky-type reaction for preparation N-substituted 3-amino-2,2-difluoropropanotes 8 followed N1-C2 cyclization under basic conditions cases 3b (N-anisyl derivative) and 3c...
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In multicellular organisms, homeostasis is maintained by a balance between cell proliferation and apoptosis (programmed death). It physiological form of death responsible for the deletion non-repairable damaged, mutated, or cells which have lost their function. We describe synthesis series potential inhibitors caspases from modified aspartic acid residue (fluoromethylketone, fmk). The addition to entire of, 3-cyano-4-fluoro-benzoyl- pattern on one hand 4-fluoro-2-thiazolamino- other will...
<title>Abstract</title> <bold>Background:</bold>Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised PET/CT imaging. We evaluated whether the measurement FAPα in bronchoalveolar lavage fluids (BALF) uptake FAPI could used as biomarkers fibrogenesis.<bold>Methods:</bold>The dynamics lung of<sup>18</sup>F-labeled ([<sup>18</sup>F]FAPI-74) was assessed bleomycin mouse model at various time points using...