A5092218635- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Piperaceae Chemical and Biological Studies
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Medicinal Plants
- Ginger and Zingiberaceae research
- Nanoplatforms for cancer theranostics
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Genomics, phytochemicals, and oxidative stress
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Natural Antidiabetic Agents Studies
- Hepatitis B Virus Studies
- Metabolomics and Mass Spectrometry Studies
- Seaweed-derived Bioactive Compounds
- Free Radicals and Antioxidants
- Advanced Nanomaterials in Catalysis
- Inflammatory mediators and NSAID effects
- Phytochemistry and biological activity of medicinal plants
- Inflammatory Bowel Disease
- Pregnancy and Medication Impact
- Disaster Response and Management
- Flavonoids in Medical Research
- Plant Genetic and Mutation Studies
University of Hassan II Casablanca
2023-2025
Arthritis, a global health burden comprising osteoarthritis and rheumatoid arthritis, demands advanced therapeutic approaches. In this context, flavonoids, diverse group of naturally occurring compounds abundant in fruits, vegetables, medicinal plants, have emerged as promising candidates for mitigating the inflammatory processes associated with arthritic conditions. This review aims, first, to provide comprehensive exploration potential focusing on specific such quercetin,...
Skin cancer is the most widespread type of malignant tumor representing a major public health concern. Considering numerous side effects associated with conventional treatments, phytotherapy may be regarded as viable medicinal alternative. This study aimed to investigate therapeutic potential Orbea variegata (L.) Haw, an ornamental plant, in treating skin using animal model induced by combination ultraviolet (UV) irradiation and sulfuric acid treatment. The hydroethanolic extract underwent...
Ammi visnaga (A. visnaga) is an annual herb that has been used in traditional medicine to treat various ailments attributed the presence of its bioactive compounds. The purpose this study was identify and examine phytochemical properties hydroalcoholic extract A. using vitro vivo models. Our findings demonstrated contained a variety beneficial components, including phenols, flavonoids, tannins, coumarins, saponins, khellin, visnagin. total polyphenolic content flavonoid were 23.26 mg/GAE/g...
The Ebola virus (EBOV), a highly lethal pathogen causing hemorrhagic fever, poses persistent public health threat, with devastating multi-organ complications and high transmission potential through bodily fluids. EBOV’s pathogenesis is marked by severe oxidative stress immune dysregulation, where increased reactive oxygen species (ROS) levels foster cellular damage, hinder defenses, facilitate viral replication. Through evasion suppression of responses, EBOV affects both innate adaptive...
Tetradenia riparia (T. riparia) is a medicinal plant native to sub-Saharan Africa, traditionally used but has limited in vivo scientific validation. This study evaluated its antioxidant, toxicity, and anti-inflammatory effects using toxicity tests, paw edema, air pouch models, vascular permeability assessment. Additionally, qualitative phytochemical analysis quantitative measurements of total polyphenolic flavonoid content were conducted. In vitro assays revealed significant concentrations...
Neutrophils, the most abundant white blood cells, play a dual role in cancer progression. While they can promote tumor growth, metastasis, and immune suppression, also exhibit anti-tumorigenic properties by attacking cells enhancing responses. This review explores complex interplay between neutrophils microenvironment (TME), highlighting their ability to switch pro- anti-tumor phenotypes based on external stimuli. Pro-tumorigenic facilitate growth through mechanisms such as neutrophil...
Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing colon cancer. Their ability to modulate pivotal signaling pathways in the development progression makes them invaluable targeted therapeutics. Nevertheless, it is crucial recognize that although chalcones exhibit promise, further pre-clinical...
Inflammatory Bowel Disease-Associated Arthritis (IBD-associated arthritis) poses a significant challenge, intertwining the complexities of both inflammatory bowel disease (IBD) and arthritis, significantly compromising patient quality life. While existing medications offer relief, these drugs often initiate adverse effects, necessitating requirement for safer therapeutic alternatives.
Staphylococcal infections challenge current treatments due to adverse effects and drug resistance, prompting the exploration of plant‐derived compounds for their promising properties. This study aimed analyze Syzygium aromaticum essential oil, aqueous ethyl acetate extracts antioxidant antistaphylococcal against sensitive resistant clinical isolates. Erythrocytes were used as model cells biocompatibility. The SA‐EO was extracted via hydrodistillation identified using GC‐MS. activity assessed...
This study investigates the carcinogenic potential of chronic dermal exposure (16 weeks) to sulfuric acid (SA) in immunocompetent mice. Clinical assessments, histopathological analyses, immunohistochemical analyses and biochemical assays were conducted evaluate skin irritation, oxidative stress biomarkers effect SA. Results indicated that prolonged SA leads various alterations structure, notably inflammation, preneoplastic neoplastic proliferation hair follicles, as well hyperkeratosis...
Aframomum melegueta, commonly known as grains of paradise, is a medicinal plant celebrated for its rich phytochemical content and therapeutic properties. This study evaluated the antioxidant cytotoxic potentials ethanolic methanolic extracts, both in vitro vivo, while also analyzing their chemical profiles. HPLC analysis identified key compounds, including gallic acid, caffeic caffeine, coumarin, rutin, catechin, ferulic quercetin. Chronic toxicity assessments confirmed safety with no...