Ammi visnaga (A. visnaga) is an annual herb that has been used in traditional medicine to treat various ailments attributed the presence of its bioactive compounds. The purpose this study was identify and examine phytochemical properties hydroalcoholic extract A. using vitro vivo models. Our findings demonstrated contained a variety beneficial components, including phenols, flavonoids, tannins, coumarins, saponins, khellin, visnagin. total polyphenolic content flavonoid were 23.26 mg/GAE/g...

Antimicrobial resistance has caused major challenges in both bacterial and fungal infections. Therefore, the current study was designed to evaluate antimicrobial activity with different crude extracts of leaves seeds Citrus limon against Gram-positive (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa) fungi (Cryptococcus neoformans Candida albicans) obtained from clinical settings. Filtrate after maceration technique phytochemical...

Abstract The WHO and CDC recently declared monkeypox virus (MPXV) a zoonotic disease known as (Mpox) Public Health Emergency of International Concern. According to the CDC, no treatment is specifically approved for Mpox infections. Medicinal plants are crucial in healthcare economic development, particularly low- middle-income countries. This review offers valuable insights into pathogenesis management through therapeutic approaches vaccination strategies using plant-based molecules. Core...

Tetradenia riparia (T. riparia) is a medicinal plant native to sub-Saharan Africa, traditionally used but has limited in vivo scientific validation. This study evaluated its antioxidant, toxicity, and anti-inflammatory effects using toxicity tests, paw edema, air pouch models, vascular permeability assessment. Additionally, qualitative phytochemical analysis quantitative measurements of total polyphenolic flavonoid content were conducted. In vitro assays revealed significant concentrations...

Introduction: Gender-based violence (GBV) is directed against a person because of their gender. Both women and men experience gender-based violence, but the majority victims are girls. Sexually transmitted infections (STIs) that from one to another through sexual contact. There evidence GBV increases risk STIs pregnancy. The objective this study was determine prevalence pregnancy among patients attending Isange One Stop Center at Ruhengeri Referral Hospital. Methodology: This retrospective...

Worldwide, bacterial bloodstream infections (BSIs) constitute an important cause of morbidity and mortality in clinical settings. Due to the limited laboratory facilities sub-Saharan Africa, poor diagnosis BSIs results outcomes leads a risk antimicrobial resistance. The present work was carried out describe microbiological features using data collected from Centre Hospitalier Universitaire de Kigali (CHUK).A retrospective study at CHUK. blood culture 2,910 cases - adults, children infants...

Intracellular microorganisms, like viruses, bacteria, and fungi, pose challenges in detection due to their non-culturable forms. Transcriptomic analysis at cellular level enables exploration of distributions the impact these microorganisms on host cells, a domain that remains underexplored because methodological limitations. Single-cell technology shows promise addressing this by capturing polyadenine-tailed transcripts, recent studies confirmed polyadenylation microbial transcriptomes. We...

Abstract Background Glutathione peroxidase 1 gene ( GPX ) is one of the antioxidant enzyme that remove reactive oxygen species in a continuous process. Since identification well‐characterized functional polymorphism named p.Pro198Leu (rs1050450 C>T) gene, abundant studies have evaluated association between and tumor risk diverse population. But, available results related to breast cancer are conflicting absent Africa. The present case–control study was planned assess presence Pro198Leu...

<b><i>Background and Aims:</i></b> A common polymorphism in the tumor suppressor gene <i>p53</i> at codon 72 has been suggested to play a role development of number cancers. This studied many populations worldwide, with conflicting results. The present study was planned assess association p53 breast cancer Rwandese population. <b><i>Methods:</i></b> In this study, examined by allele-specific PCR analysis 40 patients 39 healthy...

Worldwide, the use of antibiotics is losing effectiveness due to substantial resistance antimicrobial developed by many pathogenic bacteria. African populations including Rwanda, frequently traditional medicine for primary care. This study aimed determine phytochemicals and activity Ocimum. suave (O. suave) against selected human bacteria (two strains S. aureus, P. aeruginosa, two E. coli, pneumonia, pyogene, K. oxytoca, H. influenza, sonei). The leaf stem extracts were prepared using...

Several studies have shown that older people a higher risk of exposure to viral hepatitis B and C than younger people. This study aimed determine the seroprevalence their associated factors in aged 45+ years old Burera, rural district Rwanda.A cross sectional was conducted from July December 2017 during mass campaign (HBV) (HCV) screening vaccination eligible populations against HBV Burera District. Blood samples were collected surface antigen (HBsAg) an antibody (Anti-HCV) detected using...

Worldwide, breast cancer is the most frequent neoplasm and second leading cause of death among females. It dominates in both developed developing countries represents a major public health problem. The etiology multifactorial involves exogenous agents as well endogenous factors. Although they account for only small fraction burden, mutations BRCA1 BRCA2 genes are known to confer high risk predisposition. Mutations moderate/low-penetrance may also contribute risk. Previous studies have shown...

Electronic devices have become one of the most essential accessories being used in hospitals. Those increase communication and contact making healthcare delivery more efficient quality service oriented. The study was designed to collect reliable information about spreading pathogens through electronic especially sensitive departments. objectives this were evaluate bacterial colonization determine effectiveness disinfection with alcohol 70% (<mml:math...

Multi-drug resistance patterns in bacteria are difficult to treat. The search for a new alternative antibiotic drug that may help control drug-resistant pathogenic is necessary. present study focused on the antibacterial effect of Lantana camara extracts against bacteria. Extraction was performed L. leaves and stems using maceration technique. Three extraction solvents were used. experiments carried duplicate, results statistically analyzed with SPSS. Tannins, phenols, saponins, alkaloids,...

With the rise of antimicrobial resistance, urge having new lead compounds that could inhibit microbial growth is turning into a truth. The aim present investigation was to determine activity Mystroxylon aethiopicum and Psidium guajava on selected pathogenic bacteria. Extraction with petroleum ether methanol performed both leaf powders. Agar well diffusion technique followed. All experiments were carried out in duplicate, results analyzed by SPSS. Glycosides, tannins, saponins, flavonoids,...

Infectious diseases remain a global health challenge as result of antimicrobial resistance. The use natural products has revealed potential source alternative agents. aim this research was to evaluate the antibacterial activities and phytoconstituents Tragia brevipes against pathogenic bacteria. crude extracts leaves, roots stems were obtained using polar non-polar solvents assay performed agar well diffusion disc methods. results showed that in leaves roots, flavonoids, saponins,...

<title>Abstract</title> <bold>Background:</bold> Cardiovascular disease (CVD) is a public health concern. The World Health Organization reported that approximately 17.9 million deaths result from CVD annually, accounting for 31% of all globally. <bold>Methods:</bold> A cross-sectional study with 100 simple randomly selected participants was conducted. Blood samples were collected to analyze lipid profiles, such as high-density lipoprotein (HDL-C), triglyceride (TG), total cholesterol (TC),...

Background: Poor glycemic monitoring of type 2 diabetes mellitus has been linked with dyslipidemia and this led to an augmentation mortality in diabetic patients. This study assessed the association blood glucose serum lipid concentrations patients at Gisenyi District Hospital Rwanda.Methods: investigation was cross-sectional used Cochran formula (n = Z2PQ/d2) estimate number participants. Predisposing aspects such as age, gender, pressure, BMI were obtained from Blood tested capillary...

COVID-19 is mainly described as endothelial dysfunction, and due to the bidirectional link between oxidative stress we initiated a program directed evaluation of status population Rwanda by measuring spectrophotometrically their plasma Reactive Oxygen Metabolites (d-ROMs) Plasma Antioxidant Potential (PAT). The reference was chosen reflect absence actual or past SARS-CoV-2 infections well other clinically established infective intervals for d-ROM PAT were identified. average 378.6 UCARR with...

Objective: This study aimed to evaluate the association with oral microbial community derangement and dental disorders during pregnant. Materials Methods : A total of 60 pregnant women were selected, women, 30 had disorders, remaining did not have (control group). The swab samples collected from a routine clinic visit. Samples transported INES Ruhengeri Clinical Microbiology Laboratory for identification analysis. Chi-square test (x2) was used imbalance disorders. Data analyzed by SPSS...

Malaria presents a diagnostic challenge in most tropical countries including Rwanda. Microscopy remains the gold standard for diagnosing malaria, however, it is labour intensive and depends upon skill of examiner. rapid tests (MRDTs) have been developed as an easy, convenient alternative to microscopy.A cross sectional study was conducted from October November 2019 on 130 febrile patients who were directed laboratory department blood screening malaria parasites at Byumba Health centre. The...