A5072070917- Cervical Cancer and HPV Research
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Sesquiterpenes and Asteraceae Studies
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- Urinary and Genital Oncology Studies
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Telomeres, Telomerase, and Senescence
- Reproductive tract infections research
- Lung Cancer Research Studies
- Poxvirus research and outbreaks
- DNA Repair Mechanisms
National Centre for Nuclear Energy, Science and Technology
2016-2025
National Nuclear Energy Commission
2022
Mohammed V University
2019
Meenakshi Medical College Hospital and Research Institute
2012
Tarbiat Modares University
2012
Russian Cancer Research Center NN Blokhin
1999
Signal transducer and activator of transcription (STAT) proteins are cytoplasmic factors known to play key roles in numerous physiological pathological processes, from pathogen response cancer modulation. However, the some STAT family members, particularly STAT1 STAT4, initiation progression bladder (BC) have not been comprehensively studied. The present study investigated expression pattern STAT4 prognosis survival BC taking advantage patients' specimens cell lines. In our cohort, high mRNA...
Lung cancer (LC) mutations in the epidermal growth factor receptor (EGFR), phosphoinositide 3-kinase catalytic subunit alpha (PIK3CA), and human 2 (HER2) genes represent promising targets for personalized treatment strategies. This study aims to investigate mutation profiles of these Moroccan LC patients examine their correlation with clinicopathological features. In this prospective study, specimens were collected from 60 patients. Mutations specific regions EGFR (exons 18 – 21),...
Aim: Angiogenesis is a universal hallmark of all cancers involving variety proteins including vascular endothelial growth factor (VEGF). Extensive studies have explored the potential implications single nucleotide polymorphisms (SNPs) within VEGF-A in lung cancer (LC) susceptibility, tumor growth, and their effect on gene expression level. Accordingly, we planned present study to evaluate prevalence -460T/C (rs833061), -2578C/A (rs699947), -2549I/D (rs35569394) SNPs association with...
Bladder cancer (BC) is a prevalent malignancy with poor prognosis in advanced stages. While immune checkpoint blockade has revolutionized immunotherapy, its efficacy remains limited for most BC patients. The detailed characterization of BCs tumor microenvironment (TME) prerequisite to understand these mechanisms resistance and develop new therapeutic strategies. In this study, we used genetically engineered mouse model resistant anti-PD1 treatment, patient samples, investigate the evolution...
Limited national information is available in Morocco on the prevalence and distribution of HPV-sub-types cervical cancer role other risk factors. The aim was to determine frequency investigate factors for this disease.Between November 2009 April 2012 a multicentre case-control study carried out. A total 144 cases 288 age-matched controls were included. Odds-ratios corresponding confidence-intervals computed by conditional logistic regression models.Current HPV infection detected 92.5% 13.9%...
ABSTRACT Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti‐proliferative, telomere shortening, and apoptotic effects on human cervical cancer HeLa SiHa cell lines. Tomentosin found to inhibit the growth lines in dose time‐dependent manner (IC 50 values 7.10 ± 0.78 μM 5.87 0.36 μM, respectively after 96 h treatment). As evidenced by TTAGGG length assay, tomentosin target specifically telomeric overhang lengthening. This confirmed...
Abstract Background Nasopharyngeal carcinoma (NPC) is a malignant tumor which arises in surface epithelium of the posterior wall nasopharynx. There's evidence that Epstein Barr virus (EBV) associated to NPC development. However, many epidemiologic studies point connection between viral infections by human papillomavirus (HPV) and NPC. Method Seventy Moroccan patients with were screened for EBV HPV. detection was performed PCR amplification BZLF1 gene, encoding ZEBRA (Z Epstein-Barr Virus...
The antiproliferative effect of different extracts obtained from Retama monosperma L. was investigated on human SiHa and HeLa cervical cancer cell lines using a MTT colorimetric assay. dichloromethane fraction (Rm-DF) the most active extract, exhibiting significant cytotoxic activity both in dose-dependent manner, after 72 h treatment. IC50 values were 14.57 ± 4.15 μg/ml 21.33 7.88 μg/ml, for respectively. morphological features assessment apoptosis Rm-DF-treated cells showed condensation...
Worldwide, cervical cancer is the second most common in women. High-risk human papillomavirus (HPV) play a crucial role etiology of and prevalent genotype HPV16. HPV 16 intratypic variants have been reported to differ their prevalence, biological biochemical properties. The present study was designed analyze identify type E6 among patients with Morocco.A total 103 HPV16 positive samples were isolated from 129 cases, variant status subsequently determined by DNA sequencing gene.Isolates...
Due to recent technical improvements and some encouraging new results, there has been a resurgence of interest in the possibility that substantial proportion breast cancers (BCs) may be caused by viral infections, including Human papillomavirus (HPV). The aim this study was determine prevalence mucosal cutaneous HPV tumours from Moroccan BC patients.
Tumor recurrence and progression in non-muscle invasive bladder cancer (NMIBC), therapy failure, severe side effects muscle (MIBC) are the major challenges clinical management of (BC). Here, we identify new molecular targetable signatures to improve BC patients' stratification outcome current immunotherapies.In a prospective cohort 70 patients, assessed genetic regulation TERT maintaining telomere length parallel immune checkpoint microRNA expression.TERT was undetectable healthy tissues but...
The mouse mammary tumor virus (MMTV) like sequences have been reported to be present in some human breast cancers, but their association with cancer development is still controversial.In this retrospective study, we investigated the status of MMTV-like 42 biopsies and 18 paired normal tissues from Moroccan patients cancer. env were identified by PCR confirmed direct DNA sequencing.Specific found 24 (57.14%) cases carcinomas, 6 (33.3%) matched tissues. Comparison sociologic...
Telomerase is activated in human papillomavirus (HPV) positive cervical cancer and targeting telomeres offers a novel anticancer therapeutic strategy. In this study, the telomere properties, cytotoxic as well pro-apoptotic effects of hexane (IV-HE) dichloromethane (IV-DF) fractions from Inula viscosa L. extracts were investigated on HeLa SiHa cells. Our data demonstrate that IV-HE IV-DF able to inhibit cell growth cells dose-dependent manner studied resistant lines exhibited resistance...
Introduction: Many studies have indicated a causal relationship between genital human papillomavirus (HPV) infections and cervical cancer. This study aimed to determine the prevalence genotypes of six high-risk oncogenic papillomaviruses in lesions from Moroccan women with normal abnormal cytology. Methodology: The included 938 Children's Mothers' Pathology Department Ibn Sina Hospital, Rabat. Cytopathology examination was done by routine PAP smear testing. HPV DNA testing conducted using...
Worldwide, Bladder cancer is the most frequent male malignancy. It third common malignancy in Morocco. The risk factors for developing bladder are multiples including dietary conditions, environmental exposure and oxidative stress. GPX1 gene encoding human cellular antioxidant enzyme glutathione peroxidase1 a key factor cell detoxification process. Pro198Leu polymorphism associated with decrease of activity may contribute to susceptibility. present case-control study was planned assess...
Vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 VEGFR2) are the most important tissue factors involved in tumor angiogenesis. The aim of this study was to evaluate promoter mutational status VEGFA expression levels VEGFA, VEGFR1, VEGFR2 bladder cancer (BC) tissues correlate results with clinical-pathological parameters BC patients. A total 70 patients were recruited at Urology Department Mohammed V Military Training Hospital Rabat, Morocco. Sanger sequencing performed...
Aberrant methylation of tumor suppressor gene promoters has been extensively investigated in cervical cancer. Transcriptional silencing, as a main consequence hypermethylation CpG islands, is the predominant mechanism p16(INK4a) and E-cadherin inactivation malignant epithelial tumors. This study was conducted to evaluate promoter status genes 22 specimens carcinomas, four cancer cell lines (HeLa, SiHa, Caski, C33A), 20 human papillomavirus negative specimens, obtained from normal swabs,...