A5057189153- Melanoma and MAPK Pathways
- Cervical Cancer and HPV Research
- Animal Virus Infections Studies
- Cutaneous Melanoma Detection and Management
- Virus-based gene therapy research
- Molecular Biology Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- RNA Research and Splicing
- Sarcoma Diagnosis and Treatment
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Ocular Oncology and Treatments
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Renal and related cancers
- PI3K/AKT/mTOR signaling in cancer
Ministry of Health of the Russian Federation
2015-2023
Ministry of Health
2021
Russian Cancer Research Center NN Blokhin
1992-2017
Cancer Research Center
2015
Russian Academy of Sciences
2003-2013
Academy of Medical Sciences
2008-2013
Institute of Bioorganic Chemistry
1976
D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences
1976
Comparative allelotyping of the short arm human chromosome 3 (3p) in four types epithelial carcinomas was performed using an identical set polymorphic markers.In total, 117 samples non-papillary renal cell carcinoma (RCC), non-small lung (NSCLC), uterine cervix (CC), and breast (BC) were screened for loss heterozygosity (LOH) with 10 di-, tri-and tetrameric markers covering nine bands 3p.High LOH frequencies detected at least one locus: RCC (36143, 84%), BC (20/26, 77%), NSCLC (16124, 67%),...
HPV16 is frequently seen in invasive cervical cancer (ICC) and intraepithelial neoplasia (CIN). Its E6 gene has frequent sequence variations. Although some variants have been reported to different biochemical or biological properties, they do not show geographical identity. Moreover, the definition of ‘variant’ a source confusion because it based on all departures from ‘prototype’ once isolated randomly an ICC case. We amplified by PCR fresh-frozen tissue 104 cases CIN Russian patients...
Abstract Serological responses to Epstein‐Barr virus (EBV)‐associated antigens were studied in nasopharyngeal carcinoma (NPC) patients 2 countries non‐endemic for the disease: USSR (77 cases) and Cuba (55 cases). Two age‐ sex‐matched control groups available, one consisting of with other head‐and‐neck tumours (OHNT) (171 from 56 Cuba), normal individuals (blood donors) (83 80 Cuba). Unlike groups, NPC both had high levels IgG IgA antibodies, similar those seen endemic areas. The only...
Gastrointestinal stromal tumors (GISTs) are the most spread mesenchymal located within gastrointestinal tract that have particular clinico-morphological, immunohistochemical and molecular characteristics. The distinguishing mark of GISTs is presence cell-surface antigen CD117 (KIT receptor tyrosine kinase), identified by immunohistochemistry. consist with various activating mutations in KIT (75–80 %) or PDGFRA (5–15 kinases. Numerous associated specific GIST morphology, histologic phenotype,...
Uveal melanoma is a tumor that has neuroectodermal origin and develops from melanocytes of uveal tract (choroid, ciliary body, iris). This disease rare variant melanoma, accounting for about 3.5% all reported cases melanoma. In the treatment metastatic already achieved considerable success, tyrosine kinase inhibitors BRAF MEK (vemurafenib, dabrafenib, trametinib, etc.) monoclonal antibodies to block CTLA-4, PD-1 PD-L1 (ipilimumab, lambrolizumab , nivolumab, are created registered, scientists...
49 Background: Gastrointestinal stromal tumours (GISTs) contain oncogenic KIT or PDGFRA tyrosine kinase (TK) mutations leading to disturbance of downstream signaling pathways that contribute GIST pathogenesis. Additional genetic aberrations were found in GISTs, demonstrating the involvement other genes important tumor progression. The aim study was evaluate prognostic relevance different TK GISTs and analyze additional according mutational status. Methods: 180 patients examined for (9, 11,...
Melanoma is the most lethal malignancy of skin, which comprised clinically relevant molecular subsets defined by specific "driver" mutations in BRAF, NRAS, and KIT genes. Recently, better results melanoma treatment were obtained with mutation-specific inhibitors that have been developed for clinical use target only patients particular tumor genotypes. The aim study was to characterize spectrum subtypes from 137 skin 14 mucosal melanoma. In total 151 cases, frequency KIT, PDGFRA, KRAS 55.0,...
Melanoma is the most dangerous malignant disease of skin with high risk relapsing and metastasis dissemination. The molecular biological studies implemented during last decade drastically altered our concepts about mechanisms carcinogenesis melanocytes. review considers both hereditary factors predisposition to melanoma (rare alleles genes CDKN2A и CDK4, mutations MITF BAP1) somatic genetic disorders involved into melanoma. These in causing hyper-activation RAS-MAPK (BRAF, NRAS, MEK, NF1)...
Introduction. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of gastrointestinal tract character diagnostic feature which is CD117 (KIT) expression. GISTs clinically diverse and have different genetic alterations that may predictive prognostic significance. Aim – study clinical, morphological features to assess overall survival (OS) patients with various profiles disorders for elucidation factors contributing prognosis. Materials methods. A total 244 GIST who...
Melanoma remains the most deadly form of malignant skin disease with high risk metastases. Metastatic melanoma is prognostic highly unfavorable and resistant to traditional chemotherapy biologic treatment. There a great progress in understanding molecular mechanisms underlying initiation progression. The external (ultraviolet irradiation) internal (genetic) factors are involved in genesis. 5–14 % cases occur familial context due genetic predisposition factors. Among them rare germinal...
Objectives. To study the changes of gastric mucosa under influence duodenogastral reflux (DGR) and Helicobacter pylori (H. pylori). Material Methods. A total 65 children treated at in-patient department Vitebsk Children’s Clinical Centre from February 2015 to 2016 34 girls, 31 boys with complaints concerning gastrointestinal tract nausea, vomiting, a burning sensation in epigastrium, vague abdominal pain principally localized epigastrium have been examined. The age group was 5 17 years....
Cutaneous melanoma is characterized by molecular heterogeneity. The work devoted to the analysis of mutational status genes involved in MAPK signaling primary and metastatic cutaneous for detection tumor sensitivity specific targeted therapy as well possible links genetic alterations with some clinical morphological features. BRAF, NRAS KIT mutations were found 60.6%, 13.8% 1% cases correspondingly. Mutational differed depending on localization, chronic UV insolation patients’ age. Thus rate...