A5102896932- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Acute Lymphoblastic Leukemia research
- PI3K/AKT/mTOR signaling in cancer
- Poxvirus research and outbreaks
- Extracellular vesicles in disease
- Cancer-related gene regulation
- RNA modifications and cancer
National Centre for Nuclear Energy, Science and Technology
2017-2023
National Nuclear Energy Commission
2022
Lung cancer (LC) mutations in the epidermal growth factor receptor (EGFR), phosphoinositide 3-kinase catalytic subunit alpha (PIK3CA), and human 2 (HER2) genes represent promising targets for personalized treatment strategies. This study aims to investigate mutation profiles of these Moroccan LC patients examine their correlation with clinicopathological features. In this prospective study, specimens were collected from 60 patients. Mutations specific regions EGFR (exons 18 – 21),...
Tumor recurrence and progression in non-muscle invasive bladder cancer (NMIBC), therapy failure, severe side effects muscle (MIBC) are the major challenges clinical management of (BC). Here, we identify new molecular targetable signatures to improve BC patients' stratification outcome current immunotherapies.In a prospective cohort 70 patients, assessed genetic regulation TERT maintaining telomere length parallel immune checkpoint microRNA expression.TERT was undetectable healthy tissues but...
HPV L1 protein is a corner stone in structure, it's involved the formation of viral capsid; widely used as systematic material and considered main component vaccines development production.The present study aims to characterize genetic variation gene 16 specimens evaluate silico impact major variants on epitope change affecting its conformational structure.A fragment from 35 confirmed were amplified by PCR sequenced.Overall, five amino acids residues changes reported: T390P specimens, M425I...
Nasopharyngeal carcinoma (NPC) is a severe malignant disease. Despite its low frequency, NPC very common in North African population. Radiotherapy the standard therapeutic treatment of NPC. However, radioresistance hampers success treatment. At molecular scale, due to genetic variations involved DNA repair pathways patients. Several studies reported that single nucleotide polymorphisms (SNPs) excision cross complementing group 1 (ERCC1) could be associated with radioresistance. In this...
Abstract Background The main epigenetic event occurring during the bladder carcinogenesis process is DNA methylation, affecting genes involved in various metabolic pathways and cell regulation. use of biological fluids such as urine sediments could be used a non-invasive approach to enhance cancer management. In this study, we aim determine promoter methylation status panel on tumor biopsies evaluate usefulness samples for assessment. Methods Using methylation-specific PCR technique,...
Single nucleotide polymorphisms (SNPs) in DNA repair genes are mainly correlated with the response to radiotherapy nasopharyngeal cancer (NPC). In NPC patients, previous research has studied association between X-ray cross-complementing group 1 and 3 (XRCC1 XRCC3) radio-therapeutic response. The objective of our study was test XRCC1 Arg399Gln XRCC3 Thr241Met Moroccan population.A total 100 patients were genotyped for genes.The results revealed that genotypes alleles both SNPs did not show...
Abstract: Nasopharyngeal cancer (NPC) is one of the most common head and neck cancers. NPC differs significantly from other cancers in its etiology, epidemiology, clinical behavior, treatment. Being highly radiosensitive, standard treatment for radiotherapy. However, radioresistance hampers success may cause local recurrence distant metastases patients. In this review, we discuss updated protocols diagnosis based on recent literature with an emphasis mechanisms at molecular level a special...
Background: Human telomerase reverse transcriptase (hTERT) promoter mutations are common genetic events in bladder cancer (BC) and have been recognized as potential biomarkers for BC diagnosis prognosis. Detection of TERT urine-based tests has previously reported to detect primary recurrent BC. This study was planned evaluate hTERT both biopsies urines from patients assess the interest usefulness introducing these better management Morocco.