A5071082682- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
Mohammed V University
2023
National Centre for Nuclear Energy, Science and Technology
2022-2023
Nasopharyngeal carcinoma (NPC) is a severe malignant disease. Despite its low frequency, NPC very common in North African population. Radiotherapy the standard therapeutic treatment of NPC. However, radioresistance hampers success treatment. At molecular scale, due to genetic variations involved DNA repair pathways patients. Several studies reported that single nucleotide polymorphisms (SNPs) excision cross complementing group 1 (ERCC1) could be associated with radioresistance. In this...
Single nucleotide polymorphisms (SNPs) in DNA repair genes are mainly correlated with the response to radiotherapy nasopharyngeal cancer (NPC). In NPC patients, previous research has studied association between X-ray cross-complementing group 1 and 3 (XRCC1 XRCC3) radio-therapeutic response. The objective of our study was test XRCC1 Arg399Gln XRCC3 Thr241Met Moroccan population.A total 100 patients were genotyped for genes.The results revealed that genotypes alleles both SNPs did not show...
Objectives: Radio-resistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment. Due to individual variations radio-sensitivity, biomarkers are needed tailor radiation Within this frame, the identification of series genetic signatures mainly SNPs for NPC patients treated with radiotherapy may help predict treatment outcome and deliver personalized therapy. The aim study was evaluate possible association between GSTP1 Ile105Val GPX1 Pro198Leu polymorphisms response patients....
Abstract: Nasopharyngeal cancer (NPC) is one of the most common head and neck cancers. NPC differs significantly from other cancers in its etiology, epidemiology, clinical behavior, treatment. Being highly radiosensitive, standard treatment for radiotherapy. However, radioresistance hampers success may cause local recurrence distant metastases patients. In this review, we discuss updated protocols diagnosis based on recent literature with an emphasis mechanisms at molecular level a special...