A5019756161- Cardiovascular Effects of Exercise
- Autopsy Techniques and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Healthcare cost, quality, practices
- Forensic Entomology and Diptera Studies
- Restraint-Related Deaths
- Poisoning and overdose treatments
- Immune Cell Function and Interaction
- Suicide and Self-Harm Studies
- Cardiac Arrhythmias and Treatments
- Forensic Toxicology and Drug Analysis
- Homicide, Infanticide, and Child Abuse
- Cardiovascular Disease and Adiposity
- Radiation Dose and Imaging
- Blood Pressure and Hypertension Studies
- IL-33, ST2, and ILC Pathways
- Advanced X-ray and CT Imaging
- Acute Ischemic Stroke Management
- Cardiomyopathy and Myosin Studies
- Traumatic Ocular and Foreign Body Injuries
- Veterinary Pharmacology and Anesthesia
University Centre of Legal Medicine
2016-2025
University of Lausanne
2011-2025
Hôpital Femme Mère Enfant
2023
University Hospital of Lausanne
2008-2020
Cliniques Universitaires Saint-Luc
2018
University Hospital of Geneva
2017
Hôpital Orthopédique de la Suisse Romande
2008
Purpose To determine if postmortem computed tomography (CT) and CT angiography help to detect more lesions than autopsy in examinations, evaluate the strengths weaknesses of each method, define their indications. Materials Methods Postmortem was performed on 500 human corpses followed by conventional autopsy. Nine centers were involved. All images read an experienced team including one forensic pathologist radiologist, blinded results. findings recorded for method categorized anatomic...
Sudden cardiac death (SCD) accounts for 10–20% of total mortality, i.e., one in five individuals will eventually die suddenly. Given the substantial genetic component SCD younger cases, postmortem testing may be particularly useful elucidating etiological factors cause this subset. The identification genes responsible inherited diseases have led to organization cardiogenetic consultations many countries worldwide. Expert recommendations are available, emphasizing importance and appropriate...
Abstract Since cardiac hypertrophy may be considered a cause of death at autopsy, its assessment requires uniform approach. Common terminology and methodology to measure the heart weight, size, thickness as well systematic use cut off values for normality by age, gender, body weight height are needed. For these reasons, recommendations have been written on behalf Association European Cardiovascular Pathology. The diagnostic work up implies search pressure volume overload conditions,...
Sudden cardiac death (SCD) is by definition unexpected and in nature. The investigation almost invariably performed a forensic pathologist. Under these circumstances the role of pathologist twofold: (1.) to determine rapidly efficiently cause manner (2.) initiate multidisciplinary process order prevent further deaths existing family members. If determined be due "natural" causes district attorney charge often refuses examinations. However, additional examinations, i.e. extensive...
Sudden cardiac death is, by definition, an unexpected, untimely caused a condition in person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typically more common older adults acquired disease, SCD also can occur the young where cause is likely to be genetically transmitted process. As these inherited disease processes affect multiple family members, it critical that deaths are appropriately and thoroughly...
Key Points Human ILC1-like cells kill tumors in a KIR-independent manner. The cytotoxicity of human is impaired AML at diagnosis but restored remission.
Sports-related sudden cardiac deaths (SrSCDs) occur most frequently in highly dynamic and/or static sports. We aimed to assess the incidence and characteristics of SrSCDs Switzerland compare SrSCD occurrence according sports categories with participation behaviour general population. Between 1999 2010, forensic reports young individuals (10–39 years age) were retrospectively reviewed categorised based on peak (increasing from I III) components A C). Data compared Swiss Sixty-nine identified....
Abstract In sudden cardiac death, an autopsy is essential step in establishing a diagnosis of inherited disease and identifying families that require screening. To evaluate aspects post-mortem practice Europe, questionnaire was designed circulated to both clinical forensic pathologists. There 48% response rate information obtained from 17 countries. The results showed wide variety the management with general tendency towards lack thorough investigation. up 40% cases, autopsies were not...
Abstract Postmortem imaging (PMI) is increasingly used in postmortem practice and considered a potential alternative to conventional autopsy, particularly case of sudden cardiac deaths (SCD). In 2017, the Association for European Cardiovascular Pathology (AECVP) published guidelines on how perform an autopsy such cases, which still gold standard, but diagnostic value PMI herein was not analyzed detail. At present, significant progress has been made diagnosis acute ischemic heart disease,...
In Switzerland, ECG screening was first recommended for national squad athletes in 1998. Since 2001 it has become mandatory selected high-risk professional sports. Its impact on the rates of sports-related sudden cardiac death (SCD) is unknown.We aimed to study incidence, causes and time trends SCD comparison unrelated exercise Switzerland.We reviewed all forensic reports SCDs German-speaking region Switzerland age group 10 39 years, occurring between 1999 2010. Cases were classified into...
Tumor recurrence and progression in non-muscle invasive bladder cancer (NMIBC), therapy failure, severe side effects muscle (MIBC) are the major challenges clinical management of (BC). Here, we identify new molecular targetable signatures to improve BC patients' stratification outcome current immunotherapies.In a prospective cohort 70 patients, assessed genetic regulation TERT maintaining telomere length parallel immune checkpoint microRNA expression.TERT was undetectable healthy tissues but...