A5004098265- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Cervical Cancer and HPV Research
- Ear and Head Tumors
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Neuroendocrine Tumor Research Advances
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Ovarian cancer diagnosis and treatment
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Peptidase Inhibition and Analysis
- Genital Health and Disease
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- AI in cancer detection
Fimlab (Finland)
2016-2025
Tampere University
2016-2025
University of Eastern Finland
2003-2025
Kuopio University Hospital
2005-2025
Tampere University Hospital
2015-2024
Beth Israel Deaconess Medical Center
2023-2024
Massachusetts General Hospital
2023-2024
The University of Texas MD Anderson Cancer Center
2023-2024
Università Cattolica del Sacro Cuore
2023-2024
Faculty of Media
2023
Optimal angiogenic and lymphangiogenic gene therapy requires knowledge of the best growth factors for each purpose. We studied therapeutic potential human vascular endothelial factor (VEGF) family members VEGF-A, VEGF-B, VEGF-C, VEGF-D as well a VEGFR-3–specific mutant (VEGF-C 156S ) using adenoviral transfer in rabbit hindlimb skeletal muscle. The significance proteolytic processing was explored adenoviruses encoding either full-length or mature (ΔNΔC) VEGF-D. Adenoviruses expressing potent...
Background— Lymphedema after surgery, infection, or radiation therapy is a common and often incurable problem. Application of lymphangiogenic growth factors has been shown to induce lymphangiogenesis reduce tissue edema. The therapeutic effect autologous lymph node transfer combined with adenoviral factor expression was evaluated in newly established porcine model limb lymphedema. Methods Results— lymphatic vasculature destroyed within 3-cm radius around an inguinal node. Lymph grafts...
Eur J Clin Invest 2011; 41 (5): 487–497 Abstract Background Despite the importance of myocardial vasculature in many pathological conditions, little information is available about cardiac and coronary lymphatic vessels normal conditions. Materials methods Vasculature was assessed by immunohistochemistry with CD 31 endothelium markers podoplanin LYVE-1 16 children 20 adult autopsy hearts. Valve biopsies were collected from eight adults. Results The highest number lymphatics found valves...
The aim of this project is to assess interobserver agreement for programmed death-ligand 1 (PD-L1) scoring on non-small cell lung cancer (NSCLC) cytological specimens in a large-scale multicenter study, by exploiting the block-derived tissue microarray (cbTMA) approach. A total 65 blocks (CB) diagnosed as NSCLC were retrospectively collected and selected TMA preparation. Hematoxylin-eosin PD-L1 stained slides digitized uploaded free web sharing platform. Participants asked provide assessment...
Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a 6‐tier diagnostic category system with associated risks of malignancy (ROMs) and management recommendations. Submandibular gland fine‐needle aspiration (FNA) uncommon higher frequency inflammatory lesions relative proportion malignancy, this may affect the ROM subsequent management. This study evaluated application MSRSGC each 734 submandibular FNAs. Methods FNA cytology specimens from 15 international...
Background— Atrial fibrillation (AF) may be triggered from arrhythmogenic foci originating atrial muscular sleeves that extend into the caval veins (CVs). The aim of this anatomic study was to evaluate both extent and arrangement myocardial fibers in CVs subjects with without a history AF. Methods Results— Twenty-five human autopsied hearts (15 men; mean age, 65.5±12 years; range, 39 80 years) were studied. Seven had previous presence morphology extensions studied microscopically CVs. Such...
Background— For clinically relevant proangiogenic therapy, it would be essential that the growth of whole vascular tree is promoted. Vascular endothelial factor (VEGF) well known to induce angiogenesis, but its capability promote larger vessels controversial. We hypothesized blood flow remodels during VEGF gene therapy and may contribute large vessels. Methods Results— Adenoviral (Ad) or LacZ control transfer was performed in rabbit hindlimb semimembranous muscles with without ligation...
BACKGROUND Secretory carcinoma (SC) of the salivary gland is a rare entity with limited published literature on cytomorphology. The authors present largest cohort to date SC fine‐needle aspiration (FNA) cases. METHODS FNA cases histologically confirmed were retrospectively retrieved from 12 academic institutions in United States, Italy, Finland, and Brazil. collated data included patient demographics, imaging findings, cytopathologic diagnoses according Milan System for Reporting Salivary...
Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has established distinct diagnostic categories reporting cytopathological findings, and each is associated with a defined risk of malignancy (ROM). However, the ROM applied at overall category level not specific particular morphological entities within category. Here, performance MSRSGC pleomorphic adenoma (PA) Warthin tumor (WT) reported. Methods pathology archives 11 institutions from 4 countries were...
Background In a previous worldwide survey, the authors showed drastic reduction in number of cytological specimens processed during coronavirus disease 2019 “lockdown” period along with an increase malignancy rates. To assess continued impact pandemic on practices around world, they undertook second follow‐up survey collecting data from post‐lockdown (2020). Methods Participants were asked to provide regarding their cytopathology activity first 12 weeks respective national (2020), which...
Abstract Background The classification terminology systems for pulmonary cytology specimens have recently emerged. Inadequate samples, classified as "nondiagnostic," raise challenges in determining the threshold of cell numbers and risk malignancy (ROM). Methods study retrospectively reviewed 248 endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) samples: 46 insufficient 60 low cellularity 142 adequate samples. Characteristics cellularity, number benign malignant...