A5103236176- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Family and Patient Care in Intensive Care Units
- Cardiovascular Health and Disease Prevention
- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Acute Ischemic Stroke Management
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Cell Adhesion Molecules Research
- Mast cells and histamine
- Emergency and Acute Care Studies
- Otitis Media and Relapsing Polychondritis
- Aortic aneurysm repair treatments
- Pleural and Pulmonary Diseases
- Cardiomyopathy and Myosin Studies
- Disaster Response and Management
- Renal and Vascular Pathologies
- Occupational and environmental lung diseases
University of Bristol
2012-2024
Institut thématique Génétique, génomique et bioinformatique
2021
At Bristol
2020
Queen's University Belfast
2004-2019
Home Office
2017
University Hospital Southampton NHS Foundation Trust
1998-2016
University of Technology Sydney
2014-2015
Southampton General Hospital
1997-2013
Queens University
2013
Jordan University of Science and Technology
2013
Atherosclerotic plaque at the carotid bifurcation is often associated with transient ischemic attack (TIA) and stroke, but mechanisms are not completely understood. Previous histological studies have been too small or insufficiently detailed to reliably determine temporal course of features instability stratify analyses by nature presenting symptoms.We performed largest-ever study symptomatic plaques from consecutive patients (n=526) undergoing endarterectomy related reproducible assessments...
Carotid angiographic plaque surface morphology is a powerful risk factor for stroke and systemic vascular risk. However, the underlying pathology unclear, better understanding required both to evaluate other forms of carotid imaging develop new treatments. Previous studies comparing with have been small unblinded, vast majority assessed only crude macroscopic appearance plaque. We performed first large study detailed histology.Carotid was classified as ulcerated, irregular, or smooth on 128...
Advances in carotid plaque imaging could allow quantification of fibrous cap thickness vivo. While a <65 microm is the accepted definition rupture-prone coronary circulation, threshold value for plaques unknown.We made detailed histological assessments 526 from consecutive patients undergoing endarterectomy symptomatic stenosis. The at thinnest and most representative part was measured.Cap be measured reliably 428 (81%) plaques. In ruptured (n=257), median 300 (IQR 200 to 500 microm) minimum...
We have reviewed the clinical records and histology of 135 patients who underwent temporal artery biopsy between 1973 1978. Biopsies were classified histologically as giant-cell arteritis (17%), atypical (6%), healed (2%), arteriosclerosis (67%), atherosclerosis (5%), or normal (3%). Most histological diagnoses made at time confirmed but eight cases which had originally been reported when reviewed. All 33 with evidence accepted (31) polymyalgia rheumatica (2) treated steroids. A further 24...
Eighty-four of 132 patients with clinically genuine cranial arteritis had histological evidence inflammation at temporal artery biopsy. The highest incidence a positive result (82%) was in biopsied before corticosteroid therapy. figure fell to 60% if corticosteroids been given for less than week biopsy and 10% thereafter.
Abstract Seventeen patients with early rheumatoid synovitis underwent synovial biopsy to assess the interrelationship between both ferritin (the intracellular iron storage protein) and Perls' positive (ferric in loose combination protein), on activity course of disease. The amount was associated a significant degree disease at time biopsy, but showed no relation way progressed over following year. In contrast, bore its presence persistent It is argued that this association direct, production...
Background —Numerous studies have suggested a link between Chlamydia pneumoniae infection, atherosclerosis, and coronary artery disease. However, it is still unclear whether C plays causal role in the pathogenesis of these conditions. Accordingly, we performed systematic dissection 3 arteries on 33 postmortem subjects studied relationship individual segments presence DNA severity associated atherosclerosis. Methods Results —The prevalence arterial was determined by polymerase chain reaction...
Previous studies have shown that atherosclerotic lesions express a number of matrix metalloproteinases (MMPs). Here we investigated whether transcript levels MMP-1, -3, -7, -9, and -12 in carotid plaques were correlated with histological features clinical manifestations.Atherosclerotic (n=50) removed from patients undergoing endarterectomy classified histologically using system proposed by Virmani et al, these tissues quantified real-time reverse-transcriptase polymerase chain...
<i>Background:</i> Thromboembolism from carotid plaque is an important cause of stroke. Identification unstable would therefore be clinically useful. Unfortunately, studies imaging have shown poor agreement with histology. However, this may due to inconsistent methods and the variability assessments histology, rather than inadequate imaging. <i>Methods:</i> We assessed reproducibility histological assessment in 60 plaques, section-to-section along length 26 plaques....
Three cases of primary intracranial tumours fulfilling the clinical and histological criteria pleomorphic xanthoastrocytoma are presented. As is typical, they occurred in young people, aged 15, 17, 22 years, were composed lipid-laden cells with frequent bizarre multinucleated forms a prominent reticulin network. However, subsequent immunohistochemistry, further review, follow-up suggest that these different entities. In one case tumour negative for GFAP but positive panel histiocytic...
Our study investigates the prevalence, patterns and predictors of tobacco smoking among early adolescent males in Northern Jordan whether asthma diagnosis affects patterns. A descriptive cross sectional design was used. Males grades 7 8 from four randomly selected high schools city Irbid were enrolled. Data on waterpipe (WP) use cigarette obtained (n = 815) using a survey Arabic language. The overall prevalence ever having smoked 35.6%, with 86.2% this group currently. Almost half sample...