A5082688752- Fish Ecology and Management Studies
- Wildlife Ecology and Conservation
- Fish Biology and Ecology Studies
- ZnO doping and properties
- Mosquito-borne diseases and control
- Quantum Dots Synthesis And Properties
- Reproductive biology and impacts on aquatic species
- Head and Neck Cancer Studies
- Ga2O3 and related materials
- Viral Infections and Vectors
- Marine and fisheries research
- Aquaculture Nutrition and Growth
- Plant and animal studies
- Nanocluster Synthesis and Applications
- Cellular Mechanics and Interactions
- Rangeland and Wildlife Management
- GaN-based semiconductor devices and materials
- Plant Parasitism and Resistance
- Electrocatalysts for Energy Conversion
- Cancer Immunotherapy and Biomarkers
- Airway Management and Intubation Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Aquatic Ecosystems and Phytoplankton Dynamics
- Human-Animal Interaction Studies
Icahn School of Medicine at Mount Sinai
2022-2024
Government of the United Kingdom
2024
Tulane University
2016-2023
Idaho Department of Fish and Game
2021-2023
Queen Mary University of London
2019-2022
Angstrom Engineering (Canada)
2021
Western University
2009-2021
Universities Space Research Association
2021
Ames Research Center
2021
University of Southampton
1997-2020
Human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) is associated with improved survival compared HPV-negative disease. However, a minority of HPV-positive patients have poor prognosis. Currently, there no generally accepted strategy for identifying these patients. We retrospectively analysed 270 consecutively treated OPSCC from three centres effects clinical, pathological, immunological, and molecular features on disease mortality. used Cox regression to examine associations...
Abstract The nature and extent of immune cell infiltration into solid tumours are key determinants therapeutic response. Here, using a DNA methylation-based approach to tumour fraction deconvolution, we report the integrated analysis composition genomics across wide spectrum cancers. Initially studying head neck squamous carcinoma, identify two distinct subgroups: ‘immune hot’ cold’, which display differing prognosis, mutation burden, cytokine signalling, cytolytic activity oncogenic driver...
// Christopher J. Hanley 1 , Fergus Noble Matthew Ward Marc Bullock Cole Drifka 3 Massimiliano Mellone Antigoni Manousopoulou 2 Harvey E. Johnston Annette Hayden Steve Thirdborough Yuming Liu David M. Smith Toby Mellows W. John Kao Spiros D. Garbis 1, Alex Mirnezami Tim Underwood Kevin Eliceiri 3, * Gareth Thomas Cancer Sciences Unit, Faculty of Medicine, University Southampton, Southampton SO16 6YD, UK Clinical and Experimental Laboratory for Optical Computational Instrumentation (LOCI),...
We demonstrate dual interface formation in nanocrystals (NCs) through cation exchange, creating epitaxial heterostructures within spherical NCs. The thickness of the inner-disk layer can be tuned to form two-dimensional (2D), single atomic layers (<1 nm). During exchange reaction from copper sulfide zinc (ZnS), we observe a solid–solid phase transformation heterostructured As is initiated, Cu ions replaced by Zn at interfaces are accommodated intrinsic vacancy sites present initial roxbyite...
// Oliver Wood 1, * , Jeongmin Woo Gregory Seumois 3, Natalia Savelyeva 1 Katy J. McCann Divya Singh 3 Terry Jones 2 Lailah Peel Michael S. Breen Matthew Ward Eva Garrido Martin Tilman Sanchez-Elsner # Gareth Thomas Pandurangan Vijayanand Christopher H. Woelk Emma King Christian Ottensmeier for the SPARC Consortium Faculty of Medicine, University Southampton & Hospital Southampton, UK Department Molecular and Clinical Cancer Liverpool, La Jolla Institute Allergy Immunology, Jolla, CA,...
Abstract Noble‐metal‐free electrocatalysts are attractive for cathodic oxygen catalysis in alkaline membrane fuel cells, metal–air batteries, and electrolyzers. However, much of the structure–activity relationship is poorly understood. Herein, comprehensive development manganese cobalt oxide/nitrogen‐doped multiwalled carbon nanotube hybrids (Mn x Co 3− O 4 @NCNTs) reported highly reversible reduction evolution reactions (ORR OER, respectively). The hybrid structures rationally designed by...
Vascular smooth muscle cells (VSMCs) play a central role in the progression of atherosclerosis, where they switch from contractile to synthetic phenotype. Because their as risk factors for we sought here systematically study impact matrix stiffness and (hemodynamic) pressure on VSMCs. Thereby, find that individually affect VSMC However, only combination hypertensive compliance, such mechanical stimuli are prevalent during leads full phenotypic including formation matrix-degrading podosomes....
Oropharyngeal squamous cell carcinoma (SCC) is staged using the TNM system. Human papillomavirus (HPV)-positive tumors have improved prognosis, despite presenting at advanced stage. Optimal treatment and stratification of HPV-positive patients are not clearly defined.We retrospectively analyzed 266 with oropharyngeal SCC for mortality feeding tube dependency related to stage, HPV status, treatment.TNM staging was prognostic in HPV-negative (stage III/IV hazard ratio [HR], 2.00; p = .05; N(+)...
Paramedic tracheal intubation has been practised in the UK for more than 20 years and is currently a core skill paramedics. Growing evidence suggests that not optimal method of airway management by paramedics may be detrimental to patient outcomes. There also current initial training 25 intubations performed in-hospital inadequate, lack ongoing practice compound this further. Supraglottic devices (eg, laryngeal mask airway), which were available when extended paramedic was first introduced,...
Abstract Reintroduction practitioners must often make critical decisions about reintroduction protocols despite having little understanding of the biology focal species. To enhance available knowledge on warru, or black-footed rock-wallaby Petrogale lateralis MacDonnell Ranges race, we conducted a trial 16 captive individuals into fenced predator and competitor exclosure An̲angu Pitjantjatjara Yankunytjatjara Lands in South Australia. We seven trapping sessions used radio-tracking camera...
Nanoscale organisation of receptor ligands has become an important approach to study the clustering behaviour cell-surface receptors. Biomimetic substrates fabricated via different nanopatterning strategies have so far been applied investigate specific integrins and cell types, but without multivalent control. Here we use DNA origami surpass limits current approaches fabricate nanoarrays adhesion processes, with nanoscale spatial resolution single-molecule Notably, nanostructures enable...
Chlamydia trachomatis is one of the major causes infertility and preventable blindness in world. The organism particular interest from an immunological point view because it few obligate intracellular bacterial pathogens. There some evidence that repeated infections humans stimulate protective immunity. However, until recently, was unclear which components adaptive immune system give rise to protection. Studies gene knockout mice reported here elsewhere now a coherent cogent picture...
Intrauterine infection of mice with a human genital tract isolate Chlamydia trachomatis (serovar F) resulted in salpingitis. In some cases, oviduct damage was sufficient to cause infertility due lumenal blockage. Parenteral immunization purified, heterologous, recombinant major outer-membrane (rMOMP) preparation reduced the proportion animals developing severe salpingitis by 77% compared mock-immunized controls, but failed reduce chlamydial colonization lower tract. contrast, immunized rMOMP...
Abstract At the scale of an individual host, mistletoes are aggregated in space, resulting from preferential perching mistletoe dispersers on previously infected plants. We hypothesized that landscape movement patterns will also promote aggregation mistletoes. This hypothesis was tested by predicting seed shadow for box Amyema miquelii (Loranthaceae) and rain, combining radiotelemetry data mistletoebird Dicaeum hirundinaceum (Dicaeidae) movements with existing gut passage time data. Thirteen...
Context Supplementary resource provision is increasingly used by conservation managers to manipulate habitat conditions that limit population growth of threatened species. These methods are popular in reintroduction programs because they can assist released individuals adapt novel environments. In situ management and reintroductions being recover warru (black-footed rock-wallaby, Petrogale lateralis MacDonnell Ranges race) on the arid Anangu Pitjantjatjara Yankunytjatjara (APY) Lands South...
A new homoleptic sublimable indium(III) guanidinate, (In[(NiPr)2CNMe2]3 (1), was synthesized from a facile high-yield procedure. Compound 1 crystallized is P space group; = 10.5989(14) Å, b 11.0030(15) c 16.273(2) α 91.190(2)°, β 96.561(2)°, γ 115.555(2)°; R 3.50%. Thermogravimetric analysis showed to produce elemental indium as residual mass. Thermolysis in sealed NMR tube carbodiimide and protonated dimethyl amine by 1H NMR. Chemical vapour deposition experiments above 275 °C with air the...
Abstract West Nile virus (WNV) is the most significant arbovirus in United States terms of both morbidity and mortality. exists a complex transmission cycle between avian hosts arthropod vector, Culex spp. mosquitoes. Human spillover events occur when humans are bitten by an infected mosquito predicting these rates infection therefore risk to may be associated with fluctuations environmental conditions. In this study, we evaluate hydrological meteorological drivers biology viral development...
The warru, or black-footed rock-wallaby (Petrogale lateralis MacDonnell Ranges race), has continued to declined dramatically in range and abundance South Australia over the last 80 years, is now considered be one of state’s most endangered species. This paper documents key indicators this decline provides context for both formation Warru Recovery Team, development objectives actions Plan. a symptom ecosystem dysfunction central Australian ranges, yet warru recovery an opportunity broadscale...
During layer-by-layer homoepitaxial growth, both the Reflection High-Energy Electron Diffraction (RHEED) intensity and x-ray reflection will oscillate, each complete oscillation indicates addition of one monolayer material. However, it is well documented, but not understood, that phase RHEED oscillations constant thus maxima in do necessarily occur at completion a layer. We demonstrate this using simultaneous situ reflectivity during growth SrTiO$_3$. show we can control by changing...