A5018183207- Prenatal Screening and Diagnostics
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Epilepsy research and treatment
University of Hassan II Casablanca
2023-2025
Centre Hospitalier Universitaire Ibn Rochd
2022-2024
Aim: Angiogenesis is a universal hallmark of all cancers involving variety proteins including vascular endothelial growth factor (VEGF). Extensive studies have explored the potential implications single nucleotide polymorphisms (SNPs) within VEGF-A in lung cancer (LC) susceptibility, tumor growth, and their effect on gene expression level. Accordingly, we planned present study to evaluate prevalence -460T/C (rs833061), -2578C/A (rs699947), -2549I/D (rs35569394) SNPs association with...
Background: Pediatric epilepsy is the most prevalent neurological disorder among children, characterized by significant heterogeneity in terms of etiology, clinical presentation, and prognosis. In developed countries, genetic testing, particularly next-generation sequencing (NGS), has become standard practice for diagnosis. Methods/Observation: This paper presents first pediatric Moroccan case series with epilepsy. The diagnosis was established using whole-exome which identified five...
Variants in SCN8A are associated with several diseases, including developmental and epileptic encephalopathy, intermediate epilepsy or mild-to-moderate self-limited familial infantile epilepsy, neurodevelopmental delays generalized disorder without hypotonia, movement disorders. Herein, we report an 8-year-old Moroccan boy of unknown origin, intellectual disability, autism spectrum disorder, hyperactivity. The patient presented a normal 46, XY karyotype comparative genomic hybridization...
Edward's syndrome or trisomy 18 is due to meiotic nondisjunction with multisystemic involvement. It characterized by craniofacial, skeletal, cardiovascular, central nervous system and genitourinary malformations. Developmental delay common in all children. Most cases are diagnosed before birth based on the mother's age detection of ultrasound abnormalities second third trimesters. A careful examination therefore very important confirm diagnosis help identify unexpected abnormalities. There...