A5046872615- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Inflammatory Bowel Disease
- Long-Term Effects of COVID-19
- Angiogenesis and VEGF in Cancer
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Antiplatelet Therapy and Cardiovascular Diseases
- Ethnobotanical and Medicinal Plants Studies
- Respiratory Support and Mechanisms
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Blood Coagulation and Thrombosis Mechanisms
- Dermatological and COVID-19 studies
- Blood groups and transfusion
- Phytochemistry and Bioactivity Studies
- Redox biology and oxidative stress
- Venous Thromboembolism Diagnosis and Management
- Pesticide Exposure and Toxicity
- Computational Drug Discovery Methods
- COVID-19 diagnosis using AI
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Glycosylation and Glycoproteins Research
Mohammed V University
2020-2025
University of Hassan II Casablanca
2017-2025
Université Internationale Abulcasis des Sciences de la Santé
2020-2023
Hôpital Universitaire International Cheikh Khalifa
2021
University of Health Sciences
2019-2020
Montreal Heart Institute
2012-2019
Université Mohammed VI des Sciences de la Santé
2016-2018
Instituto de Parasitología y Biomedicina "López - Neyra"
2017
Consejo Superior de Investigaciones Científicas
2017
Centre Hospitalier Universitaire Ibn Rochd
2017
In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated thrombosis. Moreover, they can interact viruses an important source inflammatory mediators. While a lower platelet count is associated severity mortality, little known about function during COVID-19.
Severe acute respiratory syndrome coronavirus 2 is responsible for disease 2019 (COVID-19). While COVID-19 often benign, a subset of patients develops severe multilobar pneumonia that can progress to an distress syndrome. There no cure and few treatments significantly improved clinical outcome. Dexamethasone possibly aspirin, which directly/indirectly target the biosynthesis/effects numerous lipid mediators are among those options. Our objective was define if were characterized by increased...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to a variety of clinical outcomes, ranging from the absence symptoms severe disease and ultimately death. A feature patients with 2019 (COVID-19) is abundance inflammatory cytokines in blood. Elevated levels are predictive severity outcome. In contrast, studies aimed at defining driving forces behind inflammation lungs subjects COVID-19 remain scarce.Our aim was analyze compare plasma bronchoalveolar lavage (BAL)...
Abstract Platelets are hyperactivated in coronavirus disease 2019 (COVID-19). However, the mechanisms promoting platelet activation by severe acute respiratory syndrome 2 (SARS-CoV-2) not well understood. This may be due to inherent challenges discriminating contribution of viral vs host components produced infected cells. is particularly true for enveloped viruses and extracellular vesicles (EVs), as they concomitantly released during infection share biophysical properties. To study this,...
Abstract The purpose of this study is to develop and test machine learning-based models for COVID-19 severity prediction. samples from 337 positive patients at Cheikh Zaid Hospital were grouped according the their illness. Ours first estimate illness by combining biological non-biological data with COVID-19. Moreover use ML therapeutic purposes in Morocco currently restricted, ours investigate When analysis approaches used uncover patterns essential characteristics data, C-reactive protein,...
The rapid spread of SARS-CoV-2 threatens global public health and impedes the operation healthcare systems. Several studies have been conducted to confirm infection examine its risk factors. To produce more effective treatment options vaccines, it is still necessary investigate biomarkers immune responses in order gain a deeper understanding disease pathophysiology. This study aims determine how cytokines influence severity infection. We measured plasma levels 48 blood 87 participants...
The regulation of gene expression is fundamental to health and life essentially carried out at the promoter region DNA each gene. Depending on molecular context, this may be accessible or non-accessible (possibility integration RNA polymerase not region). Among enzymes that control process, methyltransferase (DNMTs), are responsible for demethylation CpG islands, particularly regions, regulate transcription. aberrant activity these enzymes, i.e. their abnormal activity, can result in...
Tetradenia riparia (T. riparia) is a medicinal plant native to sub-Saharan Africa, traditionally used but has limited in vivo scientific validation. This study evaluated its antioxidant, toxicity, and anti-inflammatory effects using toxicity tests, paw edema, air pouch models, vascular permeability assessment. Additionally, qualitative phytochemical analysis quantitative measurements of total polyphenolic flavonoid content were conducted. In vitro assays revealed significant concentrations...
Abstract Alongside genetic events, epigenetic processes also have a considerable impact on cancer induction and progression. Histone acetyltransferases (HATs) histone deacetylases (HDACs) both coordinate to modulate modification via acetylation, an essential component of regulation concerning gene expression. In this context, HDAC inhibition has been extensively investigated as therapeutic approach discovering anticancer drugs. Nevertheless, it is still highly challenging design inhibitors...
ABSTRACT Rationale In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated thrombosis. Moreover, they can interact viruses an important source inflammatory mediators. While a lower platelet count is associated severity mortality, little known about function during COVID-19. Objective To evaluate...
Caralluma europaea is a medicinal plant used in Moroccan popular medicine, which has been employed as remedy attributed to its anti-inflammatory, antipyretic, antinociceptive, antidiabetic, neuroprotective, and antiparasitic properties. The aim of the present study was investigate antitumor activity both methanolic aqueous extract C. europaea. effects increasing concentrations extracts on human colorectal cancer HT-29 HCT116 cell lines prostate PC3 DU145 were examined proliferation using MTT...
In traditional medicine, Ficus carica (also known as fig) latex is recognized a remedy with various therapeutic effects. the present study we investigated antitumor activity of extracts and latex. We evaluated effects increasing concentrations on HCT-116 HT-29 human colorectal cell proliferation using MTT assay apoptosis induction by evaluating PARP cleavage Western blot analysis. Peel, pulp, leaves, whole fruit exerted significant antiproliferative (IC50 values 239, 343, 177, 299, 206...
Treatment of kidney stones is based on symptomatic medications which are associated with side effects such as gastrointestinal symptoms (e.g., nausea, vomiting) and hepatotoxicity. The search for effective plant extracts without the above has demonstrated involvement antioxidants in treatment stones. A local survey Morocco previously revealed frequent use Rubia tinctorum L. (RT) In this study, we first explored whether RT ethanolic (E-RT) ethyl acetate (EA-RT) could prevent occurrence...