A5042894334- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Metal complexes synthesis and properties
- Organometallic Compounds Synthesis and Characterization
- Crystallography and molecular interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Organometallic Complex Synthesis and Catalysis
- Synthesis and biological activity
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Covalent Organic Framework Applications
- Ferrocene Chemistry and Applications
- Various Chemistry Research Topics
- Reproductive System and Pregnancy
- Amino Acid Enzymes and Metabolism
- Histone Deacetylase Inhibitors Research
- Chemical Thermodynamics and Molecular Structure
- African Botany and Ecology Studies
- Nuclear Receptors and Signaling
- Epigenetics and DNA Methylation
Sunway University
2016-2025
University of Malaya
2011-2015
Hospital Kuala Lumpur
2015
The incorporation of dithiocarbamate ligands in the preparation metal complexes is largely prompted by versatility this molecule. Fascinating coordination chemistry can be obtained from study such ranging their preparation, solid-state properties, solution behavior as well applications bioactive materials and luminescent compounds, to name a few. In overview, platinum-group elements form focus discussion. structural aspects these will discussed based upon intriguing findings solid-...
The regulation of gene expression is fundamental to health and life essentially carried out at the promoter region DNA each gene. Depending on molecular context, this may be accessible or non-accessible (possibility integration RNA polymerase not region). Among enzymes that control process, methyltransferase (DNMTs), are responsible for demethylation CpG islands, particularly regions, regulate transcription. aberrant activity these enzymes, i.e. their abnormal activity, can result in...
Abstract Two polymorphs of Cy 3 PAu[SC(OEt)=N(C 6 H 4 Cl-3)], that is a triclinic form ( P <m:math xmlns:m="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <m:mrow> <m:mover accent="true"> <m:mn>1</m:mn> <m:mo>‾</m:mo> </m:mover> </m:mrow> </m:math> $\overline{1}$ with Z ′ = 1; the α -form) and monoclinic 2 1 / c ; β have been characterised. The molecular structures feature linear P–Au–S coordination geometries close intramolecular Au⋯O(ethoxy) contacts 3.1552(17) 3.097(2) Å for -...
Interactions of the type C–H⋯π(CuCl⋯HNCS), <italic>i.e</italic>. C–H⋯π(quasi-chelate ring) where a six-membered quasi-chelate ring is closed by an N–H⋯Cl hydrogen bond, are presented.
Bacterial infection remains a worldwide problem that requires urgent addressing. Overuse and poor disposal of antibacterial agents abet the emergence bacterial resistance mechanisms. There is clear need for new approaches development therapeutics. Herein, potential molecules based on dithiocarbamate anions, general formula R(R’)NCS2(−), metal salts transition metals main group elements, summarized. Preclinical studies show broad range potential, these investigations are supported by...
The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to essentially linear gold atom coordination geometries defined by phosphane-P thiolate-S atoms, exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μg/ml against four Gram-positive bacteria, namely Bacillus cereus, Enterococcus faecalis, faecium Staphylococcus aureus; compounds 1–3 are less potent a broad panel 16 Gram-negative bacteria. As bactericidal...
ABSTRACTBackground The process of drug development and discovery is costly slow. Although an understanding molecular design principles biochemical processes has progressed, it essential to minimize synthesis-testing cycles. An effective approach analyze key heteroatoms, including oxygen nitrogen. Herein, we present analysis focusing on the utilization nitrogen atoms in approved drugs.Research methods work examines frequency, distribution, prevalence, diversity a dataset comprising 2,049...
Compact molecular structures of antimicrobial (R<sub>3</sub>PAu)<sub>2</sub>L (R = Et (<bold>1</bold>), Ph ((<bold>2</bold>) and Cy ((<bold>3</bold>); LH<sub>2</sub> {1,4-[MeOC(S)-N(H)]<sub>2</sub>C<sub>6</sub>H<sub>4</sub>}), arise from intramolecular Au⋯π(aryl) interactions, proven by theory to be attractive 12 kcal mol<sup>–1</sup> more stable than anticipated Au⋯O interactions.
The metal–organic framework (MOF) [Cd(tp)(bpe)]2.2DMF (1) was synthesized solvothermally [DMF; 393 K; 3 days; tpH2 = terephthalic acid and bpe 1,2-di(4-pyridyl)ethylene]. When the analogous reaction conducted hydrothermally, a supramolecular isomer (SI) formed, i.e., [Cd(tp)(bpe)] (2). SI 1 comprises layers, arising from tp κ2O,O′ μ2-κ2O,O′:κ1O coordination, pillared by staves; in 2, both carboxylates of one coordinate mode, other, are μ2-κ2O,O′:κ1O. Solid-state interconversion between 2 not...
Gold compounds have shown promise in the treatment of non-communicable diseases such as rheumatoid arthritis and cancer, are considered value anti-microbial agents against Gram-negative Gram-positive bacteria, anti-parasitic properties Schistosoma mansoni, Trypanosoma brucei, Plasmodium falciparum, Leishmania infantinum, Giardia lamblia, Entamoeba histolytica. They known to affect enzymatic activities that required for cellular respiration processes.Anti-amoebic effects phosphanegold(I)...
Abstract A conformational polymorph, form β, for Ph 3 PAu[SC(OEt)=NPh] has been characterised. Like the original structure (form α), molecule features a linear P–Au–S geometry. The difference between molecular structures rests with relative disposition of thiolate ligand which places N-bound aryl ring in close proximity to gold centre β) rather than oxygen atom α). Density functional theory calculations show Au···π interaction is more stable by 5.2 kcal/mol one Au···O contact. packing both...
The Y group in (CH 2 CH ) NC(S)SCH C 6 H 4 -4-Y, = Cl, Br, I, Me and NO , plays a preeminent role the molecular packing.
The title compound, C 10 H 13 NOS, is a second monoclinic polymorph (space group P 2 1 / c , Z ′ = 2) of the previously reported 2/ ( 1) [Tadbuppa & Tiekink (2005). Z. Kristallogr. New Cryst. Struct . 220 395–396]. Two independent molecules comprise asymmetric unit new and each these exists as thioamide–thione tautomer. In molecule, central CNOS chromophore strictly planar [r.m.s. deviations 0.0003 0.0015 Å] forms dihedral angles 6.17 (5) 20.78 (5)° with N-bound 3-tolyl rings, thereby...
1 : co-crystals formed between 1,4-diiodotetrafluorobenzene and each of the three isomeric n -pyridinealdazines ( = 2, 3 4), featuring I⋯N halogen bonding contacts within one-dimensional chains, are described.
Abstract A review of the crystallographic literature is presented whereby structures featuring a quasi-six-membered chelate ring type {CuCl…HNCS} were evaluated for presence intermolecular C–H…π(quasi-chelate) interactions. These are shown to stabilise crystal leading zero-, one-, two- and even three-dimensional architectures. Details these interactions described comparison analogous formed intramolecularly has been made. The in occur one-third where such contacts can potentially form.