A5061089487- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Protein Kinase Regulation and GTPase Signaling
- Renal Transplantation Outcomes and Treatments
- Bacterial Infections and Vaccines
- Amoebic Infections and Treatments
- Extracellular vesicles in disease
- Organ Transplantation Techniques and Outcomes
- Gut microbiota and health
- Digestive system and related health
- Legionella and Acanthamoeba research
- Cancer Research and Treatments
- Dermatological and COVID-19 studies
- Mesenchymal stem cell research
- Organ Donation and Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Université Laval
2018-2024
Centre hospitalier universitaire de Québec
2020-2024
University Health Network
2021
University of Toronto
2021
Toronto General Hospital
2021
Centre hospitalier de l'Université Laval
2020
Severe acute respiratory syndrome coronavirus 2 is responsible for disease 2019 (COVID-19). While COVID-19 often benign, a subset of patients develops severe multilobar pneumonia that can progress to an distress syndrome. There no cure and few treatments significantly improved clinical outcome. Dexamethasone possibly aspirin, which directly/indirectly target the biosynthesis/effects numerous lipid mediators are among those options. Our objective was define if were characterized by increased...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to a variety of clinical outcomes, ranging from the absence symptoms severe disease and ultimately death. A feature patients with 2019 (COVID-19) is abundance inflammatory cytokines in blood. Elevated levels are predictive severity outcome. In contrast, studies aimed at defining driving forces behind inflammation lungs subjects COVID-19 remain scarce.Our aim was analyze compare plasma bronchoalveolar lavage (BAL)...
Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA2-IIA efficiently bacterial membranes. Here, we show that affects immune system by acting on intestinal microbial flora. Using mice overexpressing transgene-driven human sPLA2-IIA, found microbiota was critical for both induction an...
ABSTRACT BACKGROUND Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent responsible for Coronavirus disease 2019 (COVID-19). While SARS-CoV-2 infections are often benign, there also severe COVID-19 cases, characterized by bilobar pneumonia that can decompensate to an acute respiratory distress syndrome, notably increased inflammation and a cytokine storm. no cure against some treatments significantly decrease severity of disease, aspirin dexamethasone, which...
The increased usage of marginal grafts has triggered interest in perfused kidney preservation to minimize graft injury. We used a donation after circulatory death (DCD) porcine autotransplantation model compare 3 the most frequently ex vivo perfusion techniques: nonoxygenated hypothermic machine (non-oxHMP), oxygenated (oxHMP), and normothermic (NEVKP).Following 30 min warm ischemia, were retrieved preserved with either 16 h non-oxHMP, oxHMP, or NEVKP (n = 5 per group). After contralateral...