A5074688010- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Antibiotic Resistance in Bacteria
- Antimicrobial agents and applications
- Force Microscopy Techniques and Applications
- Bacterial biofilms and quorum sensing
- Supramolecular Chemistry and Complexes
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Phytochemistry and Biological Activities
- Nanoparticles: synthesis and applications
- Click Chemistry and Applications
- Crystallography and molecular interactions
- Ethnobotanical and Medicinal Plants Studies
- Nanoparticle-Based Drug Delivery
- African Botany and Ecology Studies
- Cell death mechanisms and regulation
- Mechanical and Optical Resonators
- Hepatitis B Virus Studies
- Antibiotic Use and Resistance
- Pharmaceutical and Antibiotic Environmental Impacts
Université de Lorraine
2016-2025
Laboratoire Lorrain de Chimie Moléculaire
2017-2024
Centre National de la Recherche Scientifique
2014-2023
Délégation Centre-Est
2015-2023
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2021
Université de Limoges
2003-2019
Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes
2007-2018
Cancers et Préventions
2009
Laboratoire de Chimie Physique et Microbiologie pour l'Environnement
2008
Laboratoire de Chimie Physique
2004
ABSTRACT Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity antimicrobials now evolving. We evaluated potential for synergy colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vancomycin against 12 isolates Acinetobacter baumannii ( n = 4), Pseudomonas aeruginosa Klebsiella pneumoniae 4). The strains included six multidrug-resistant isolates, K. ATCC 700603,...
Multidrug-resistant (MDR) bacteria constitute a global health issue. Over the past ten years, interest in nanoparticles, particularly metallic ones, has grown as potential antibacterial candidates. However, there is no consensus about procedure to characterize nanoparticles (MNPs; i.e., aggregates) and evaluate their activity, it impossible conclude real effectiveness new agent. To give part of answer this question, 12 nm gold silver have been prepared by chemical approach. After...
Abstract Objective The aim of this study was to assess the impact sex on management and outcome patients according aortic stenosis (AS) severity. Introduction Sex differences in AS are poorly understood. Methods Doppler echocardiography data with at least mild-to-moderate [aortic valve area (AVA) ≤1.5 cm2 peak jet velocity (VPeak) ≥2.5 m/s or mean gradient (MG) ≥25 mmHg] were prospectively collected between 2005 2015 retrospectively analysed. Patients reduced left ventricular ejection...
Over the coming years, skin cancer could become a significant public health problem. Previous results indicate that ursolic acid (UA), pentacyclic triterpene acid, has pleiotropic biologic activities such as antiinflammatory and antiproliferative on cells. As UA represents promising chemical entity for protection of human skin, in agreement with tests done by cosmetic industry, we investigated its effects M4Beu melanoma cell line. In this report, demonstrated first time had effect M4Beu,...
In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure responsible for poor overall survival rate. Cisplatin exposure sensitive cells has been previously associated with a down-regulation Bcl-X(L) expression apoptosis, whereas was systematically observed when maintained. could thus constitute an interesting chemosensitizing strategy. We showed that Bcl-X(L)targeted RNA interference strategy efficiently sensitized chemoresistant...
A novel pH- and glutathione-responsive drug delivery system has been developed by deposition of tannic acid (TA)–Fe(<sc>iii</sc>) complex on the surface mesoporous silica nanoparticles (MSN).
Saccharomyces cerevisiae and Candida albicans are model yeasts for biotechnology human health, respectively. We used atomic force microscopy (AFM) to explore the effects of caspofungin, an antifungal drug in hospitals, on these two species. Our nanoscale investigation revealed similar, but also different, behaviors response treatment with drug. While administration caspofungin induced deep cell wall remodeling both yeast species, as evidenced by a dramatic increase chitin decrease β-glucan...
Emergence of multidrug-resistant bacteria has encouraged vigorous efforts to develop antimicrobial agents with new mechanisms action. In this study, the in vitro antibacterial activity para-guanidinoethylcalix[4]arene was evaluated and compared that its constitutive monomer, para-guanidinoethylphenol. Hexamidine, a widely used antiseptic, synthalin A, an old antidiabetic anti-trypanosomal compound, were chosen as references.MIC MBC determined for five reference strains (Escherichia coli ATCC...
The demand for dry juniper (Juniperus communis) needles as a raw material the food, pharmaceutical, and cosmetic industries has increased rapidly in recent years. Juniper are known to be rich terpenoids phenolics, but their chemical composition antibacterial properties have not been well-characterized. In this study, we describe soluble phenolic terpenoid of collected Finland (n = 125) demonstrate that concentration these compounds clearly with latitude altitude with, however, stronger...