A5081805770- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Cholesterol and Lipid Metabolism
- Bioactive natural compounds
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- NF-κB Signaling Pathways
- Receptor Mechanisms and Signaling
- Medicinal Plants and Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Immune Response and Inflammation
- Neurological Disorders and Treatments
- Phytochemicals and Antioxidant Activities
- Aluminum toxicity and tolerance in plants and animals
- PARP inhibition in cancer therapy
- Saffron Plant Research Studies
- Regulation of Appetite and Obesity
- Immune cells in cancer
- Vitamin C and Antioxidants Research
- Flavonoids in Medical Research
- CRISPR and Genetic Engineering
- Medicinal Plants and Neuroprotection
Tunis El Manar University
2011-2024
Tunis University
2006-2024
Université de Bourgogne
2019
Laboratoire de Neurobiologie Cellulaire et Moléculaire
2006
In the prevention of neurodegeneration associated with aging and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), neuronal differentiation is interest. this context, neurotrophic factors are a family peptides capable promoting growth, survival, and/or both developing immature neurons. contrast to these peptidyl compounds, polyphenols not degraded in intestinal tract able cross blood–brain barrier. Consequently, they could potentially be used as therapeutic agents...
Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well subjects concerned civilization (type 2 diabetes, bowel diseases, metabolic syndrome). The involvement increased 7-ketocholesterol pathophysiology these widely suspected. Indeed, elevated...
Oxidative stress, associated with a variety of disorders including neurodegenerative diseases, results from accumulation reactive oxygen species (ROS). stress is not only responsible for neuron apoptosis, but can also provoke astroglial cell death. Numerous studies indicate that pituitary adenylate cyclase-activating polypeptide (PACAP) promotes survival, nothing known regarding the action PACAP on survival. Thus, purpose present study was to investigate potential glioprotective effect...
Astroglial cells possess an array of cellular defense mechanisms, including superoxide dismutase (SOD) and catalase antioxidant enzymes, to prevent damages caused by oxidative stress. Nevertheless, astroglial cell viability functionality can be affected significant We have previously shown that pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent glioprotective agent prevents hydrogen peroxide (H2 O2 )-induced apoptosis in cultured astrocytes. The purpose this study was...
Oxidative stress, induced by various neurodegenerative diseases, initiates a cascade of events leading to apoptosis, and thus plays critical role in neuronal injury. In this study, we have investigated the potential neuroprotective effect octadecaneuropeptide (ODN) on 6-hydroxydopamine (6-OHDA)-induced oxidative stress apoptosis cerebellar granule neurons (CGN). ODN, which is produced astrocytes, an endogenous ligand for both central-type benzodiazepine receptors (CBR) metabotropic receptor....
Astrocytes synthesize and release endozepines, a family of regulatory peptides, including the octadecaneuropeptide (ODN) an endogenous ligand both central-type benzodiazepine (CBR) metabotropic receptors. We have recently shown that ODN exerts protective effect against hydrogen peroxide (H(2)O(2))-induced oxidative stress in astrocytes. The purpose present study was to determine type receptor transduction pathways involved cultured rat first observed activity at very low concentrations...
Oxidative stress, resulting from accumulation of reactive oxygen species (ROS), plays a critical role on astrocyte death associated with neurodegenerative diseases. Astroglial cells produce endozepines, family biologically active peptides that have been implicated in cell protection. Thus, the purpose present study was to investigate potential protective effect one octadecaneuropeptide ODN, hydrogen peroxide (H(2) O(2) )-induced oxidative stress and rat astrocytes. Incubation cultured...
Astroglial cells possess an array of cellular defense systems, including superoxide dismutase (SOD) and catalase antioxidant enzymes, to prevent damage caused by oxidative stress on the central nervous system. Astrocytes specifically synthesize release endozepines, a family regulatory peptides octadecaneuropeptide (ODN). ODN is ligand both central-type benzodiazepine receptors (CBR), adenylyl cyclase- phospholipase C-coupled receptor. We have recently shown that potent protective agent...
Oxidative stress plays a major role in triggering astroglial cell death diverse neuropathological conditions such as ischemia and neurodegenerative diseases. Numerous studies indicate that hemoglobin (Hb) is expressed both resting reactive glia cells, but nothing known regarding possible of Hb on survival. Thus, the purpose present study was to investigate potential glioprotective effect hydrogen peroxide (H2O2)-induced oxidative apoptosis cultured rat astrocytes. Our demonstrates...
Astrocytes specifically synthesize and release endozepines, a family of regulatory peptides including octadecaneuropeptide (ODN). We have previously reported that ODN rescues neurons astrocytes from 6-OHDA-induced oxidative stress cell death. The purpose this study was to examine the potential implication miR-34b, miR-29a, miR-21 in protective activity on death cultured rat astrocytes. Flow cytometry analysis showed 6-OHDA increased number early apoptotic dead cells while treatment with...
Oxidative stress is involved in the pathogenesis of smoking-related disease. Protection astrocytes from oxidative insult appears essential to maintain brain function. In this study, we have investigated effect gestational cigarette exposure on astrocyte survival. Pregnant female were randomly allocated control group or smoke which they placed an chamber and inhale three cigarettes twice a day for period 20 days. The was kept same duration, but without smoke. Newborn rats both groups weighed...
Abstract: Astrocytes synthesize and release endozepines, a family of neuropeptides related to diazepam‐binding inhibitor (DBI). Astroglial cells also express the receptors pituitary adenylate cyclase‐activating polypeptide (PACAP) vasoactive intestinal (VIP). In present article, we show that PACAP dose dependently increases DBI gene expression stimulates endozepine through activation PAC1‐R. cAMP formation, enhances polyphosphoinositide turnover, evokes calcium mobilization from...
Trans-resveratrol (RSV) is a non-flavonoid polyphenol (stilbene) with numerous biological activities, such as anti-tumor activities. However, RSV rapidly metabolized, which limits its therapeutic use. The availability of analogues similar activities for use in vivo therefore major challenge. For this purpose, several isomeric RSV, aza-stilbenes (AZA-ST 1a-g), were synthesized, and their toxicities characterized compared to those on murine N2a neuronal cells using especially flow cytometric...
Trans-resveratrol is a natural polyphenol showing numerous biological properties, especially anti-tumoral and antioxidant activity. Among resveratrol derivatives, aza-stilbenes, which bear an imine bound, show interesting activities. In the present study, we synthesized series of analogs trans-resveratrol (seven aza-stilbenes) following easy low-cost procedure green chemistry. The toxicity currently unknown, was evaluated on murine neuronal N2a cells, comparatively to trans-resveratrol, by...