A5047921962- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Radiotherapy Techniques
- Colorectal Cancer Screening and Detection
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Geomagnetism and Paleomagnetism Studies
- Radiation Therapy and Dosimetry
- Nanoparticle-Based Drug Delivery
- Breast Implant and Reconstruction
- Biotechnology and Related Fields
- Sensor Technology and Measurement Systems
- Photoacoustic and Ultrasonic Imaging
- Radiation Dose and Imaging
- Electrical and Bioimpedance Tomography
- Congenital gastrointestinal and neural anomalies
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced MRI Techniques and Applications
- Biosimilars and Bioanalytical Methods
- Biomedical Ethics and Regulation
- Urologic and reproductive health conditions
- Salivary Gland Tumors Diagnosis and Treatment
University of Twente
2012-2022
Health Forecasting
2022
National Institute for Public Health and the Environment
2022
Klinik und Poliklinik für Nuklearmedizin
2019
University Hospital Münster
2019
Imagerie et Cerveau
2011-2018
Medisch Spectrum Twente
2010
Sentinel lymph node biopsy (SLNB) with a superparamagnetic iron oxide (SPIO) tracer was shown to be non-inferior the standard combined technique in SentiMAG Multicentre Trial. The MRI subprotocol of this trial aimed develop magnetic alternative for pre-operative lymphoscintigraphy (LS). We evaluated feasibility using following administration localization sentinel nodes (SLNs) and its potential non-invasive identification (LN) metastases.Patients breast cancer scheduled undergo SLNB were...
Abstract Background A procedure for sentinel lymph node biopsy (SLNB) using superparamagnetic iron-oxide (SPIO) nanoparticles and intraoperative (SLN) detection was developed to overcome drawbacks associated with the current standard-of-care SLNB. However, residual SPIO can result in void artefacts at follow-up magnetic resonance imaging (MRI) scans. We present a grading protocol quantitatively assess severity of these offer an option minimise impact on diagnostic imaging. Methods Follow-up...
Abstract The identification of regulatory challenges for nanotechnology-enabled health products, followed by discussions with the involved stakeholders, is first step towards a strategic planning how such can be successfully addressed in future. In order to better understand whether identified needs are sector-specific products or might also hinder progress other domains, REFINE consortium reached out communities representing sectors that exploit potential nanotechnology, i.e. industrial...
Introduction: Breast cancer staging with sentinel lymph node biopsy relies on the use of radioisotopes, which limits availability procedure worldwide. The a magnetic nanoparticle tracer and handheld magnetometer provides radiation-free alternative, was recently evaluated in two clinical trials. hydrodynamic particle size used differs substantially from radioisotope could therefore benefit optimization. aim this study to assess performance three different-sized tracers for within an vivo...
As the first step in developing a new clinical technique for magnetic detection of colorectal sentinel lymph nodes (SLNs), method is developed to measure content intact, formalin fixated using vibrating sample magnetometer (VSM). A suspension superparamagnetic nanoparticles injected ex vivo around tumor resected colon segments. selection three excised from region and separately measured VSM. The iron quantified moment curve Langevin model superparamagnetism bimodal particle size...
Purpose Data‐driven gating (DDG) approaches for positron emission tomography (PET) are interesting alternatives to conventional hardware‐based methods. In DDG, the measured PET data themselves utilized calculate a respiratory signal, that is, subsequently used purposes. The success of is then highly dependent on statistical quality data. this study, we investigate how determines signal noise and thus motion resolution in clinical scans using center‐of‐mass‐based (COM) DDG approach,...
To assess the feasibility and merits of a complete magnetic approach for sentinel lymph node biopsy (SLNB) procedure in oral cancer patients. This study included ten patients (stage cT1-T2N0M0) scheduled elective neck dissection (END). Superparamagnetic iron oxide nanoparticles (SPIO) were administered peritumorally prior to surgery. A preoperative MRI was acquired identify nodes (LNs) with uptake. detector used hotspots prior, during, after SLNB procedure. The resected LNs (SLNs) evaluated...
Nodal status is the most important prognostic factor in colorectal cancer (CRC). Small occult metastases may remain undetected on conventional histopathological examination, potentially resulting undertreatment. Ex vivo sentinel lymph node mapping (SLNM) can be used to improve accuracy of nodal staging, but currently tracers suffer from drawbacks, which hamper implementation technique routine clinical practice. Magnetic are optimal size for (SLN) retention and allow objective quantitative...
Abstract The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance safety therapeutic diagnostic procedures address wide range diseases. However, successful translation these technologies from their inception (proof-of-concept) clinical practice been challenged by substantial gaps scientific technical capacity R&D companies, especially SMEs, keep up with ever-evolving...
Background and objectives:To determine prognosis treatment, accurate nodal staging is essential in many tumor types. After injection of clinical grade superparamagnetic iron oxide (SPIO) nanoparticles, it has been shown that metastatic lymph nodes can be distinguished from benign specimens usin g MR imaging. However, does not benefit per-operative which requires a non-ionizing, small volume, high resolution, fast imaging technique. In vivo non-invasive photoacoustic (PA) might facilitate...
Abstract The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance safety therapeutic diagnostic procedures address wide range diseases. However, successful translation these technologies from their inception (proof-of-concept) clinical practice been challenged by substantial gaps scientific technical capacity R&D companies, especially SMEs, keep up with ever-evolving...