A5065090179- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
- Celiac Disease Research and Management
- Hepatitis B Virus Studies
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Pancreatitis Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Biliary and Gastrointestinal Fistulas
- Bone and Joint Diseases
- Tattoo and Body Piercing Complications
- Sarcoidosis and Beryllium Toxicity Research
- IgG4-Related and Inflammatory Diseases
- Congenital Anomalies and Fetal Surgery
- Diet and metabolism studies
- Bone health and treatments
- Blood properties and coagulation
- Abdominal vascular conditions and treatments
- Pregnancy and Medication Impact
- HIV/AIDS oral health manifestations
- Microscopic Colitis
Boston Children's Hospital
2018-2024
Harvard University
2018-2024
Beth Israel Deaconess Medical Center
2023
University of Ferrara
2017-2018
Arcispedale Sant'Anna
2017-2018
University of Pisa
2011-2017
Azienda Ospedaliera Universitaria Pisana
2014-2016
Ospedale Santa Chiara
2013-2015
Background and Aims: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, real‐world lacking. This study aimed to elucidate the natural history of liver disease in contemporary, international cohort children with ALGS. Approach Results: was multicenter retrospective clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 August 2019. Native survival (NLS) event‐free rates...
Background and Aims: Alagille syndrome (ALGS) is characterized by chronic cholestasis with associated pruritus extrahepatic anomalies. Maralixibat, an ileal bile acid transporter inhibitor, approved pharmacologic therapy for cholestatic in ALGS. Since long-term placebo-controlled studies are not feasible or ethical children rare diseases, a novel approach was taken comparing 6-year outcomes from maralixibat trials aligned harmonized natural history cohort the G lobal AL agille A lliance...
Celiac disease (CD) is common in patients with autoimmune liver (AILD); however, the long-term response to treatment of AILDs coexistent CD has not been explored detail. The aim present study was analyze features and immunosuppressive children hepatitis (AIH) associated CD.Retrospective prospective evaluation followed at a single center.Among 79 AIH, 15 (19%) had (9 type 1, 3 2, seronegative). In group AIH CD, female sex significantly more represented than alone; also, former group,...
Abstract TE measures liver stiffness to assess fibrosis. Its use in post‐transplant patients was reported few small pediatric studies. We evaluated ability predict graft fibrosis a large cohort while comparing it the performance of APRI and FIB‐4. also investigated effect type on LSMs. Patients at Boston Children's Hospital who underwent LT LSM ≤ 1 year from biopsy (2007‐2018) were eligible. Ninety‐four (45%M) aged 1‐21 years (89% < 18 years; 13% 2 years) Median time between...
Piercing is the practice of puncturing some parts body, including area stomach, to apply ornamental objects. The presence oral and perioral piercings are a risk factor for numerous acute chronic complications, such as chipping dental enamel, lesions gums infection. in cavity may also act stimulant inflammation determine modifications components saliva. aim this study evaluate whether there variation inflammatory or immunitary saliva adult patients with labial tongue piercings. Twenty-five...
To the Editor: We read with interest ESPGHAN Hepatology Committee Position Statement on Paediatric Autoimmune Liver Disease (1). were, however, surprised that giant cell hepatitis associated autoimmune haemolytic anaemia (GCH-AHA) was not included among paediatric liver conditions having a likely pathogenesis. GCH-AHA is rare disease of infancy unknown aetiology characterised by severe Coombs-positive anaemia. The current reasons to believe in an immune-mediated pathogenesis are (2) 1....
Besides the transient bilirubin transport immaturity, preterm infants are particularly at risk for different forms and degrees of bile formation impairment because metabolic demands that not matched by functional maturation in first weeks life. Cholestasis, affecting approximately 1 2 500 infants, is more commonly reported with an incidence varying between 10 20%, it mainly due to a combination factors including delayed enteral nutrition, low birth weight, prolonged parenteral hypoxia,...