A5006533887- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Clinical Nutrition and Gastroenterology
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Liver Diseases and Immunity
- Hepatitis C virus research
- Muscle Physiology and Disorders
- Metabolism and Genetic Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Organ Transplantation Techniques and Outcomes
- Lipid metabolism and biosynthesis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pancreatitis Pathology and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Immune Cell Function and Interaction
Cleveland Clinic
2016-2025
Cleveland Clinic Lerner College of Medicine
2015-2025
Case Western Reserve University
2013-2025
MetroHealth Medical Center
2001-2023
Creative Commons
2021
Bridge University
2021
University Gastroenterology
1998-2020
Stanford University
2020
National Institute on Alcohol Abuse and Alcoholism
2019
The Geneva Association
2018
The prognoses with respect to mortality and hepatic nonhepatic outcomes across the histologic spectrum of nonalcoholic fatty liver disease (NAFLD) are not well defined.
Supported by the American Association for Study of Liver Diseases. Dr. Lai is partially supported R01 AG059183 and R21 AG067554. Srinivasan Dasarathy NIH RO1 GM119174; DK113196; P50 AA024333; AA021890; 3U01AA026976 ‐ 03S1; UO1 AA 026976; R56HL141744;UO1 DK061732; 5U01 DK062470‐17S2. Potential conflict interest: received grants from Axcella Lipocine. Bernal advises Versantis. Purpose Scope This Practice Guidance first Diseases (AASLD) practice guidance on management malnutrition, frailty,...
Sarcopenia is associated with increased wait‐list mortality, but a standard definition lacking. In this retrospective study, we sought to determine the optimal of sarcopenia in end‐stage liver disease (ESLD) patients awaiting transplantation (LT). Included were 396 newly listed for LT 2012 at 5 North American transplant centers. All computed tomography scans read by 2 individuals interobserver correlation 98%. Using image analysis software, total cross‐sectional area (cm ) abdominal skeletal...
Adult nonalcoholic fatty liver disease (NAFLD) is characterized by absent or mild portal chronic inflammation (CI); in children, CI may be predominant. This study correlated clinical features with CI. Centrally-graded biopsies and temporally-related parameters from 728 adults 205 children. From the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) were evaluated. Mild, more than no found 60%, 23% 16% of adult 76%, 14% 10% pediatric biopsies. Autoantibodies, elevated alanine...
<h3>Importance</h3> The histologic evolution of the full spectrum nonalcoholic fatty liver disease (NAFLD) and factors associated with progression or regression remain to be definitively established. <h3>Objective</h3> To evaluate NAFLD changes in severity over time. <h3>Design, Setting, Participants</h3> A prospective cohort substudy from Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Database study, a noninterventional registry, was performed at 8 university medical...
Significance Loss of skeletal muscle mass, or sarcopenia, is nearly universal in cirrhosis and adversely affects the outcome these patients. There are no established therapies to prevent reverse sarcopenia because mechanisms not known. We show that expression myostatin, a negative regulator increased cirrhotic mediated by ammonia concentration. Skeletal concentrations significantly cirrhosis, resulting activation transcription factor NF-κB, which turn increases myostatin. Given high...
Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here, we demonstrate gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked obesity and energy metabolism. In multiple clinical cohorts, systemic levels of TMAO were observed strongly associate with type 2 diabetes. addition, circulating associated traits different inbred strains represented Hybrid Mouse...
No therapy has been shown to reduce the risk of serious adverse outcomes in patients with nonalcoholic steatohepatitis (NASH).To investigate long-term relationship between bariatric surgery and incident major liver cardiovascular events (MACE) obesity biopsy-proven fibrotic NASH without cirrhosis.In SPLENDOR (Surgical Procedures Long-term Effectiveness Disease Obesity Risk) study, 25 828 biopsies performed at a US health system 2004 2016, 1158 adult were identified who fulfilled enrollment...
Cirrhosis is the consequence of progression many forms necro-inflammatory disorders liver with hepatic fibrosis, hepatocellular dysfunction, and vascular remodeling. Reversing primary disorder, transplantation, controlling complications are major management goals. Since former options not available to majority cirrhotics, treating remains mainstay therapy. Sarcopenia and/or cachexia most common complication adversely affects survival, quality life, development other cirrhosis, outcome after...
Frailty has emerged as a powerful predictor of outcomes in patients with cirrhosis and inevitably made its way into decision making within liver transplantation. In an effort to harmonize integration the concept frailty among transplant centers, AST ASTS supported efforts our working group develop this statement from experts field. is multidimensional construct that represents end-manifestation derangements multiple physiologic systems leading decreased reserve increased vulnerability health...
Loss of muscle mass and function, or sarcopenia, is a common feature cirrhosis contributes significantly to morbidity mortality in this population. Sarcopenia main indicator adverse outcomes population, including poor quality life, hepatic decompensation, patients with evaluated for liver transplantation (LT), longer hospital intensive care unit stay, higher incidence infection following LT, overall health cost. Although it clear that an important predictor LT outcomes, many questions...