A5078849443- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Radiation Dose and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound in Clinical Applications
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Neuroblastoma Research and Treatments
- Gallbladder and Bile Duct Disorders
- Radiology practices and education
- Pediatric Urology and Nephrology Studies
- Liver Diseases and Immunity
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Spinal Fractures and Fixation Techniques
- Ultrasound Imaging and Elastography
- Nutrition and Health in Aging
- Intraperitoneal and Appendiceal Malignancies
- Congenital Anomalies and Fetal Surgery
University of Cincinnati Medical Center
2018-2025
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2013-2025
Children's Hospital & Medical Center
2021-2025
Society of Nuclear Medicine and Molecular Imaging
2017-2024
The Medical Center of Aurora
2023-2024
Sabin Vaccine Institute
2023
Tuberous Sclerosis Association
2021
House of Representatives
2021
Trout Unlimited
2021
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disease affecting multiple body systems with wide variability in presentation. In 2013, Pediatric Neurology published articles outlining updated diagnostic criteria and recommendations for surveillance management of manifestations. Advances knowledge approvals new therapies necessitated a revision those recommendations.Chairs working group cochairs from the 2012 International TSC Consensus Group were invited to meet...
Changes in the plant community and ecosystem properties that follow conversion of agriculture to restored tallgrass prairies are poorly understood. Beginning 1995, we established a species-rich, prairie chronosequence where ∼3 ha agricultural land have been converted each year. Our goals were examine differences between these adjacent fields determine changes in, potential interactions between, occur over time prairies. During summers 2000–2002, examined species cover, soil C N, net N...
We assessed the performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in children to stratify hepatic steatosis grade before and after treatment Cysteamine Bitartrate Delayed‐Release for Treatment Nonalcoholic Fatty Liver Disease Children (CyNCh) trial, using centrally scored histology as reference. Participants had multiecho 1.5 Tesla (T) or 3T MRI on scanners from three manufacturers. Of 169 enrolled children, 110 (65%) 83 (49%) liver biopsy at baseline end...
Background CT deep learning reconstruction (DLR) algorithms have been developed to remove image noise. How the DLR affects quality and radiation dose reduction has yet be fully investigated. Purpose To investigate a algorithm’s improvement for pediatric CT. Materials Methods was compared with filtered back projection (FBP), statistical-based iterative (SBIR), model-based (MBIR) in retrospective study by using data from examinations of patients (February December 2018). A comparison object...
Purpose To prospectively assess agreement and repeatability of magnetic resonance (MR) elastography liver stiffness measurements across imager manufacturers, field strengths, pulse sequences. Materials Methods This prospective cross-sectional study was approved by the institutional review board; informed consent obtained from all subjects. On basis an a priori power calculation, 24 volunteer adult subjects underwent MR with four imaging systems (two vendors) multiple sequences...
Purpose To assess the diagnostic performance of magnetic resonance (MR) elastography-derived liver stiffness to detect fibrosis in a pediatric and young adult population with spectrum diseases. Materials Methods This retrospective study included patients younger than 21 years age who underwent MR elastography biopsy within 3 months one another between January 2012 September 2016 for indications other transplantation or Fontan palliation congenital heart disease. examinations were reprocessed...
Background Proton density fat fraction (PDFF) estimated by using chemical shift–encoded (CSE) MRI is an accepted imaging biomarker of hepatic steatosis. This work aims to promote standardized use CSE estimate PDFF. Purpose To assess the accuracy methods for estimating PDFF determining linearity and range bias observed in a phantom. Materials Methods In this prospective study, commercial phantom with 12 vials known values were shipped across nine U.S. centers. The underwent 160 independent...
Quantification of Hepatic Steatosis by Ultrasound: Prospective Comparison With MRI Proton Density Fat Fraction as Reference StandardJonathan R. Dillman, MD, MSc1,2, Samjhana Thapaliya, MD1, Jean A. Tkach, PhD1,2 and Andrew T. Trout, MD1,2,3Audio Available | Share
Despite the literature supporting efficacy of vertebroplasty for treatment osteoporotic vertebral compression fractures, few reports exist documenting its use in fractures multiple myeloma patients. Accordingly, we sought to characterize imaging characteristics, clinical course, and outcomes patients treated with vertebroplasty.We performed a retrospective review outcome data from 67 since October 2000. Quantitative including Roland Morris Disability Questionnaire (RDQ) Visual Analog Scales...
Objective: To determine small bowel distention, scanning time, and side effects of commercially available oral contrast agents used in cross-sectional enterography. Methods: Ten healthy volunteers ingested 2000 mL water, methylcellulose, polyethylene glycol (PEG), or 1350 low-concentration barium (LCB) followed by 500 water on different days. Magnetic resonance imaging occurred every 10 minutes from 30 to 90 after ingestion. Small distention was compared between time points agents....
Purpose To determine the agreement of proton density fat fraction (PDFF) measurements obtained with hepatic magnetic resonance (MR) imaging among readers, imager manufacturers, and field strengths. Materials Methods This HIPAA-compliant study was approved by institutional review board. After providing informed consent, 24 adult volunteers underwent one 1.5-T MR unit (Ingenia; Philips Healthcare, Best, Netherlands) two different 3.0-T units (750 W [GE Waukesha, Wis] Ingenia) on same day to...
Purpose To compare two-dimensional (2D) gradient-recalled echo (GRE) and 2D spin-echo (SE) echo-planar imaging (EPI) magnetic resonance (MR) elastography for measurement of hepatic stiffness in pediatric young adult patients suspected having liver disease. Materials Methods In this institutional review board-approved, HIPAA-compliant study, 58 underwent both GRE SE-EPI MR at 1.5 T during separate breath holds. Liver (mean means; kilopascals) was measured by five blinded reviewers. Pooled...