A5015659565- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Diet and metabolism studies
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- Pathogenesis and Treatment of Hiccups
- Child Nutrition and Feeding Issues
- Complementary and Alternative Medicine Studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Clinical Nutrition and Gastroenterology
- Intestinal and Peritoneal Adhesions
- Intestinal Malrotation and Obstruction Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Pelvic floor disorders treatments
- Digestive system and related health
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
Temple University Hospital
2014-2025
Virtua Health
2024
Temple University
2013-2023
Temple University Health System
2023
University Gastroenterology
2018-2021
George Washington University
2021
Gomal University
2021
Pyloric dysfunction has been associated with gastroparesis, particularly diabetic gastroparesis. Endoscopic functional luminal imaging probe (EndoFLIP) uses 16 sensors inside a balloon that is inflated sphincter to assess physiologic characteristics. The aim of this study was measure the pressure, diameter, cross-sectional area (CSA), and distensibility pylorus using EndoFLIP in patients In addition, relationship between pyloric pathophysiology gastroparesis etiology, symptoms, gastric...
Noncardiac chest pain is associated with poor quality of life and high care expenditure. The majority noncardiac either gastresophageal reflux disease related or due to esophageal motility disorders, the rest are considered functional (FCP) central peripheral hypersensitivity. Current treatment FCP improves 40-50% patients. Cannabinoid receptors 1 (CB1) 2 (CB2) modulate release neurotransmitters; CB1 located in epithelium reduces excitatory enteric transmission potentially could reduce We...
Limited research exists regarding the relationship between small intestinal bacterial overgrowth (SIBO), bowel transit (SBT), and colonic (CT). Furthermore, symptom analysis is limited subtypes of SIBO: hydrogen producing (H-SIBO) methane (M-SIBO). The primary aims this study are to: compare SBT CT in patients with a positive lactulose breath test (LBT) to those normal study; among H-SIBO or M-SIBO; severity symptoms LBT M-SIBO.A retrospective review was performed for 89 who underwent whole...
Summary Background Patients with gastroparesis and related disorders have symptoms including early satiety, postprandial fullness bloating. Buspirone, a 5‐HT 1 receptor agonist, may improve fundic accommodation. Aim To determine if buspirone treatment improves satiety in patients of gastroparesis. Methods This 4‐week multi‐centre clinical trial randomised moderate‐to‐severe (Gastroparesis Cardinal Symptom Index [GCSI] satiety/postprandial subscore [ES/PPF]) to (10 mg orally) or placebo three...
Abstract Background Understanding factors that impair quality of life (QOL) in gastroparesis is important for clinical management. Aims: (a) Determine QOL patients with gastroparesis; (b) QOL. Methods Gastroparetic patientsAQ6 underwent history and questionnaires assessing symptoms (PAGI‐SYM Rome III), (SF‐36v2 PAGI‐QOL), depression (Beck Depression Inventory [BDI]), anxiety (State Trait Anxiety InventoryAQ7). Key Results 715 (256 diabetic (DG), 459 idiopathic (IG)) were evaluated. SF‐36...
Gastroparesis is a complication following lung transplantation. This study aimed to assess the prevalence of gastroparesis in patients with transplants undergoing solid phase gastric emptying scintigraphy (GES). Specifically, we investigated which type transplant more susceptible and whether timing GES post-transplantation impacts diagnosis severe gastroparesis.
SUMMARY Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan performed. The objective of this determine usage patterns in clinical practice and estimate quantitative qualitative performance metrics as they are applied Barrett's esophagus (BE) management. All procedures...
Background: Eosinophilic esophagitis is a chronic inflammatory disease with mucosal accumulation of eosinophils. There paucity data among racial/ethnic groups other than white patients. Aim: To determine if differences exist in clinical presentation, endoscopic appearance, and biopsy results adult patients (age ≥18 y) eosinophilia examine the prevalence at an urban hospital over 10-year period. Methods: Pathology reports searched Temple University Hospital 2000 to 2009; key words:...
Patients with chronic constipation who do not respond to initial treatments often need further evaluation for dyssynergic defecation (DD) and slow transit (STC). The aims of this study are characterize the prevalence DD STC in patients referred a motility center correlate diagnoses patient demographics, medical history, symptoms. High-resolution ARM (HR-ARM), balloon expulsion testing (BET) whole gut scintigraphy (WGTS) consecutive were reviewed. completed questionnaires describing their...
Patients often are evaluated for gastroparesis because of symptoms occurring with meals. Gastric emptying scintigraphy (GES) is used diagnosis, although results not well correlated symptoms. The aim this study to assess relationships between symptoms, gastric (GE), and accommodation (GA). completed the Patient Assessment Upper GI Symptoms (PAGI-SYM) recorded during GES water load satiety test (WLST), an indirect assessment GA. A total 109 patients were assessed. Symptom severity increased...
The goal of this study was to determine the effect and safety domperidone on QTc interval at commonly prescribed doses 30 80 mg daily.Domperidone is a dopamine receptor antagonist used for treatment gastroparesis. However, it has been associated with QT prolongation, ventricular arrhythmias, sudden cardiac death.This analyzed patients gastroparesis between January 2012 September 2017 single center. This reviewed EKGs, primarily interval, taken baseline, 2 6 months after initiation...
Abstract Background Gastrointestinal (GI)‐specific anxiety has been identified as a treatment target in irritable bowel syndrome. However, GI‐specific understudied other GI functional/motility disorders. Among adults with gastroparesis, we aimed to: (1) initially validate measure of anxiety, the Visceral Sensitivity Index (VSI); and (2) evaluate relationship between gastroparesis symptom severity quality life, compared to measures depression, somatization. Methods Consecutive adult patients...
IMD 0 and WLST were assessed for their clinical utility in assessing patients with symptoms of gastroparesis. Low is associated less gastric retention heartburn. Volume water consumed during WLST, while IMD0, has associations early satiety, postprandial fullness, loss appetite, nausea. appear to overlap somewhat assessment physiology adults gastroparesis but relate different dyspeptic symptoms.