A5080639191- Gastrointestinal motility and disorders
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Pediatric Pain Management Techniques
- Infant Nutrition and Health
- Infant Health and Development
- Gastroesophageal reflux and treatments
- Gut microbiota and health
- Digestive system and related health
- Intestinal Malrotation and Obstruction Disorders
- Infant Development and Preterm Care
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Pharmaceutical studies and practices
- Clostridium difficile and Clostridium perfringens research
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal disorders and treatments
- Child Nutrition and Water Access
- Child and Adolescent Health
- Metabolism and Genetic Disorders
- Adolescent and Pediatric Healthcare
- Breastfeeding Practices and Influences
Children's Nutrition Research Center at Baylor College of Medicine
2016-2025
Texas Children's Hospital
2016-2025
Baylor College of Medicine
2016-2025
United States Department of Agriculture
2011-2024
Duke University
2024
Agricultural Research Service
1999-2023
Baylor School
2023
Arkansas Children's Nutrition Center
1995-2021
Rush University Medical Center
2021
University College Hospital
2020
Summary Background A low fermentable oligosaccharides, disaccharides, monosaccharides and polyols ( FODMAP ) diet can ameliorate symptoms in adult irritable bowel syndrome IBS within 48 h. Aim To determine the efficacy of a childhood whether gut microbial composition and/or metabolic capacity are associated with its efficacy. Methods In double‐blind, crossover trial, children Rome III completed 1‐week baseline period. They then were randomised to or typical American TACD ), followed by 5‐day...
The gut microbiome influences myriad host functions, including nutrient acquisition, immune modulation, brain development, and behavior. Although human microbiota are recognized to change as we age, information regarding the structure function of during childhood is limited. Using 16S rRNA gene shotgun metagenomic sequencing, characterized structure, function, variation healthy pediatric in a cohort school-aged, pre-adolescent children (ages 7–12 years). We compared with that adults...
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
Background Data on enteral feeding management of premature infants are limited and often not the subject randomized clinical trials. Several small studies suggest benefits from early initiation feeding, but do assess combined effects time tube-feeding method, type milk used. Either singly or in combination, these treatments may affect growth, bone mineralization, biochemical measures nutritional status, tolerance, and, ultimately, duration hospitalization. Methods. A total 171 infants,...
We sought to determine whether a low fermentable substrate diet (LFSD) decreases abdominal pain frequency in children with irritable bowel syndrome (IBS) and identify potential microbial factors related efficacy. Pain symptoms, stooling characteristics, breath hydrogen methane, whole intestinal transit time, stool microbiome, metabolite composition were collected and/or documented eight IBS at baseline during one week of an LFSD intervention. (P < 0.05), severity pain-related interference...
Abstract Background Rater reproducibility of the Bristol Stool Form Scale ( BSFS ), which categorizes stools into one seven types, is unknown. We sought to determine reliability and agreement by individual stool type when responses are categorized Rome III clinical designation as normal or abnormal (constipation diarrhea). Methods Thirty‐four gastroenterology providers from three institutions rated 35 photographs using . Twenty rerated photographs. Key Results 1190 ratings were completed....
The objective of this study was to report on the measurement properties Pediatric Quality Life Inventory (PedsQL) Gastrointestinal Symptoms Module for patients with functional gastrointestinal (GI) disorders (FGIDs) and organic GI diseases, hereafter referred as "GI disorders," patient self-report ages between 5 18 parent proxy-report 2 years.The 74-item PedsQL 23-item Generic Core Scales were completed in a 9-site by 584 682 parents. Patients had physician-diagnosed (such chronic...
Accurate diagnosis and stratification of children with irritable bowel syndrome (IBS) remain challenging. Given the central role recurrent abdominal pain in IBS, we evaluated relationships pediatric IBS intestinal microbes fecal metabolites using a comprehensive clinical characterization multiomics strategy. Using rigorous phenotyping, identified preadolescent (aged 7 to 12 years) Rome III (n = 23) healthy controls 22) characterized their microbial communities whole-genome shotgun...