A5108456403- Congenital Heart Disease Studies
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Transplantation: Methods and Outcomes
- Breastfeeding Practices and Influences
- Cardiovascular Function and Risk Factors
- Clinical Nutrition and Gastroenterology
- Infant Development and Preterm Care
- Cardiomyopathy and Myosin Studies
- Child Nutrition and Feeding Issues
- Obesity, Physical Activity, Diet
- Phytoestrogen effects and research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mechanical Circulatory Support Devices
- Cell Adhesion Molecules Research
- Diabetes Management and Research
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Viral gastroenteritis research and epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Tracheal and airway disorders
- Cardiac Arrest and Resuscitation
South West London and St George's Mental Health NHS Trust
2025
St George’s University Hospitals NHS Foundation Trust
2025
Baylor College of Medicine
2008-2020
St Bartholomew's Hospital
2016-2020
The University of Texas Health Science Center at Houston
2019
Centers for Disease Control and Prevention
2019
Texas Children's Hospital
2000-2017
United States Department of Agriculture
1995-2017
Children's Nutrition Research Center at Baylor College of Medicine
2004-2016
Southern Utah University
2015-2016
Objective. Compared with preterm formula (PF), mother's milk (MM) is associated lower rates of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) among premature infants. Because not all mothers infants produce sufficient to supply their throughout hospitalization, we reasoned that pasteurized donor human (DM) would be a suitable alternative. Methods. Extremely (<30 weeks gestation) whose intended breastfeed were assigned randomly receive either DM or PF if the own MM became...
Objectives. The aim of this study was to elucidate the frequency major clinical manifestations in children with mitochondrial disease and establish their course, prognosis, rates survival depending on features. Methods. We performed a retrospective review medical records 400 patients who were referred for evaluation disease. By use modified Walker criteria, only assigned definite diagnosis included study. Results. A total 113 pediatric identified. 102 (90%) underwent muscle biopsy as part...
Background Data on enteral feeding management of premature infants are limited and often not the subject randomized clinical trials. Several small studies suggest benefits from early initiation feeding, but do assess combined effects time tube-feeding method, type milk used. Either singly or in combination, these treatments may affect growth, bone mineralization, biochemical measures nutritional status, tolerance, and, ultimately, duration hospitalization. Methods. A total 171 infants,...
Severe obesity increases the prevalence of metabolic syndrome, and moderate acute weight loss with a very low-calorie diet in obese subjects syndrome leads to significant benefits. Adiponectin has been implicated both pathogenesis obesity-related insulin resistance increased inflammation. We analyzed relationship adipocyte-derived hormone adiponectin indices inflammation, adiposity, (MS+, n = 40) without (MS−, examined effects rapid loss. MS+ had significantly lower (7.6 ± 0.6 vs. 10.4...
OBJECTIVES. The objectives of this study were to determine the prevalence hyperglycemia in extremely low birth-weight infants and whether increases risk early adverse outcomes (death or intraventricular hemorrhage grade 3 4) and/or affects length hospital stay among survivors without hemorrhage. METHODS. charts all (n = 93) admitted Texas Children's Hospital (Houston, TX) during 2001 reviewed. highest daily blood glucose concentrations, dopamine infusion rates, percentage inspired oxygen,...
Dystrophin gene mutations cause 2 common muscular dystrophies, Duchenne dystrophy (DMD) and Becker (BMD). Both are frequently associated with dilated cardiomyopathy (DCM) premature death. We hypothesized that early diagnosis treatment of DCM in DMD/BMD patients would lead to ventricular remodeling specific dystrophin predict cardiac involvement.Sixty-nine boys DMD (n=62) BMD (n=7) (mean age, 12.9 13.7 years, respectively) were referred our Cardiovascular Genetics Clinic for evaluation,...
Objective. Empyema remains a significant cause of morbidity in children. This study evaluates the changes that have affected outcome children with pleural empyema, including emergence resistant organisms, introduction pneumococcal conjugate vaccine, and earlier treatment video-assisted thoracoscopy (VATS). Methods. A retrospective chart review was performed on all patients who were discharged diagnosis empyema community-acquired pneumonia over 10-year period (1993–2002) at Texas Children’s...
Background —Restrictive cardiomyopathy (RCM) is rare in children, and the prognosis poor. In present study, we evaluated all pediatric patients with RCM who were at our institution during a 31-year period to determine clinical outcome cause of death. Those sustained sudden, unanticipated cardiac arrests for risk factors that are predictive sudden Methods Results —Eighteen consecutive reviewed. Presentation, course, laboratory data, histopathological evidence ischemia compared between without...
Plasma B-type natriuretic peptide (BNP) levels are elevated in adults with heart failure and correlate functional classification prognosis. The range predictive power of BNP concentrations children chronic failure, however, not known.Whole blood were measured 53 consecutive patients left ventricular (LV) systolic dysfunction (biventricular hearts, ejection fraction < 50%, > 3 months since diagnosis). Children who had been hospitalized within before potential enrollment those 2 or 21 years...
Near-infrared spectroscopy is a noninvasive method of measuring local tissue oxygenation (StO2). Abdominal StO2 measurements in preterm piglets are directly correlated with changes intestinal blood flow and markedly reduced by necrotizing enterocolitis. The objectives this study were to use near-infrared establish normal values for abdominal infants test whether these who develop enterocolitis.We conducted 2-year prospective cohort where we prospectively measured infants, reference compared...
Obesity has been linked to cardiovascular disease, hypertension, diabetes and the metabolic syndrome, with elevated markers of systemic inflammation. Intercellular adhesion molecule-1 (ICAM-1) is a transmembrane molecule involved in leukocyte migration sites In human obesity, expression soluble form ICAM-1 (sICAM-1) positively correlated abdominal fat deposition. Increases adiposity have also macrophage infiltration into adipose tissue. Here we investigate tissue production transcriptional...
Objectives: The purpose of this study was to determine the incidence renal insufficiency in children hospitalized with acute decompensated heart failure and whether worsening function is associated adverse cardiovascular outcome. Design: Prospective observational cohort study. Setting: Single-center children's hospital. Patients: All pediatric patients from birth age 21 yrs admitted our institution October 2003 2005. Interventions: None. Measurements Main Results: Acute defined as new-onset...
Asthma and obesity incidence is increasing worldwide, asthma often more severe in the obese. Eotaxin, a CC chemokine, important extrinsic asthma, an inflammatory disorder.Our objective was to examine relation between eotaxin obesity.We conducted comparison study of mice fed high-fat vs. standard chow diet for 26 wk, obese lean humans, humans before after 4-6 wk weight loss, sc visceral adipose tissue from patients undergoing bariatric surgery.Our clinical occurred outpatient loss...
To determine the sequela of right ventricular pacing in children with congenital complete atrioventricular block.Pacing is a well-accepted therapy for patients block. The long-term this population has not been well described.We performed cohort study on all block who underwent pacemaker implantation at our institution from 1972 to 2004. Patients associated heart disease or dysfunction prior were excluded.A total 63 included study. median age was 6.5 years, an average follow-up 9.9 years....
Osteomyelitis is a common pediatric musculoskeletal infection. This infection can weaken the normal bone structure, resulting in risk of pathologic fracture. The purpose this study was to evaluate factors for fracture children with Staphylococcus aureus osteomyelitis.Seventeen who were treated long-bone secondary osteomyelitis between January 2001 and 2009 at tertiary-care hospital identified. These patients compared control group consisting forty-nine without matched age, sex, methicillin...