A5072152157- Eosinophilic Esophagitis
- Anesthesia and Pain Management
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Eosinophilic Disorders and Syndromes
- Allergic Rhinitis and Sensitization
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Chromatin Remodeling and Cancer
- Nausea and vomiting management
- Genomics and Chromatin Dynamics
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Airway Management and Intubation Techniques
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- Spine and Intervertebral Disc Pathology
- Primate Behavior and Ecology
- Anesthesia and Neurotoxicity Research
- Protein Degradation and Inhibitors
- RNA and protein synthesis mechanisms
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
California University of Pennsylvania
2012-2024
ENT and Allergy
2024
Penn Center for AIDS Research
2022
University Hospital Southampton NHS Foundation Trust
2019-2020
National Institute for Health Research
2020
NIHR Southampton Biomedical Research Centre
2020
Philadelphia University
2012-2019
Children's Hospital & Medical Center
2019
Significance Obesity has reached pandemic levels, prompting the need for novel therapeutics. The immune system been suggested to be critically linked metabolic health, leading prospect of immune-directed therapies. We report that obese fat tissue contains multiple distinct populations macrophages with unique distributions, transcriptomes, chromatin landscapes, and functions. These results provide a higher resolution cellular functional heterogeneity within adipose framework which develop new...
Summary Concise guidelines are presented that relate abnormalities of coagulation, whether the result administration drugs or pathological processes, to consequent haemorrhagic risks associated with neuraxial and peripheral nerve blocks. The advice is based on published known properties anticoagulant drugs. Four separate Tables address drugs, blocks, obstetric anaesthesia special circumstances such as trauma, sepsis massive transfusion.
The rates of childhood allergic conditions are changing, prompting the need for continued surveillance. Examination healthcare provider-based diagnosis data is an important and lacking methodology needed to complement existing studies that rely on participant reporting. Utilizing our care network 1,050,061 urban sub-urban children, we defined two retrospective cohorts: (1) a closed birth cohort 29,662 children (2) cross-sectional 333,200 children. These cohorts were utilized determine...
A study was conducted to examine the posthatch growth performance of high-yielding broilers when eggs were incubated at 3 different embryo temperatures from 2 flocks breeders ages (different egg size). Two thousand, four hundred broiler breeder (29 and 57 wk age) same strain (Cobb × Cobb) in incubator for 16 d 37.5°C. Following candling, transferred into hatcher cabinets starting 36.5°C (low, L), 37.6°C (middle, M), 38.7°C (high, H) adjusted achieve a shell temperature 37.5°C (L), 38.6°C...
Abstract Eukaryotic microorganisms are important but understudied components of the human microbiome. Here we present a pipeline for analysis deep sequencing data on single cell eukaryotes. We designed new 18S rRNA gene-specific PCR primer set and compared published gene internal transcribed spacer (ITS) set. Amplicons were tested against 24 specimens from defined eukaryotes eight well-characterized stool samples. A software https://sourceforge.net/projects/brocc/ was developed taxonomic...
ABSTRACT We investigated the spatial and temporal response of murine gut microbiome to infection with Citrobacter rodentium , an attaching-and-effacing bacterium that provokes innate adaptive immune responses, resulting in transient bacterial colitis. Previous studies have suggested C. -induced inflammation is associated increased abundance Enterobacteriaceae . report here a deeper analysis this model using DNA bar coding 454 pyrosequencing characterize 101,894 partial 16S rRNA gene...
The coronavirus disease 2019 (COVID-19) pandemic caused dramatic changes in daily routines and health care utilization delivery patterns the United States. Understanding influence of these associated public interventions on asthma is important to determine effects patient outcomes identify measures that will ensure optimal future delivery.We sought pediatric asthma-related utilization, respiratory viral testing, air pollution during COVID-19 pandemic.For time period January 17 May 17, 2015...
The nuclear receptor peroxisome proliferator-activated γ (PPARγ) is known to regulate lipid metabolism in many tissues, including macrophages. Here we report that peritoneal macrophage respiration enhanced by rosiglitazone, an activating PPARγ ligand, a PPARγ-dependent manner. Moreover, required for even the absence of exogenous ligand. Unexpectedly, dramatically affects oxidation glutamine. Both glutamine and have been implicated alternative activation (AA) macrophages, was interleukin 4...
Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to alleviate liver fibrosis, which is a devastating feature leading hepatic dysfunction. Here, we integrated single-nucleus transcriptomics and epigenomics characterize all major cell types during NASH development in mice humans. The bifurcation of hepatocyte trajectory with progression was conserved between At the fatty (NAFL) stage, hepatocytes exhibited metabolic adaptation, whereas at subset...
The ataxia telangiectasiamutated (ATM) gene encodes a serine/threonine protein kinase that plays critical role in genomic surveillance and development. Here, we use peptide library approach to define the <i>in vitro</i> substrate specificity of ATM activity. analysis identified an optimal sequence with central core motif LSQE is preferentially phosphorylated by ATM. contributions amino acids surrounding serine were assessed utilizing specific libraries or individual substrates. All...