A5071024069- Cancer survivorship and care
- Cancer Immunotherapy and Biomarkers
- Cancer-related cognitive impairment studies
- Circadian rhythm and melatonin
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Tryptophan and brain disorders
- Light effects on plants
- Nutrition and Health in Aging
- Diet and metabolism studies
- Plant Molecular Biology Research
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Brain Metastases and Treatment
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
Jiangnan University
2024-2025
University of Pennsylvania
2022-2023
Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to alleviate liver fibrosis, which is a devastating feature leading hepatic dysfunction. Here, we integrated single-nucleus transcriptomics and epigenomics characterize all major cell types during NASH development in mice humans. The bifurcation of hepatocyte trajectory with progression was conserved between At the fatty (NAFL) stage, hepatocytes exhibited metabolic adaptation, whereas at subset...
Background: Depressive symptoms (DepS) are prevalent among patients with breast cancer. Offering an anti-inflammatory diet is a promising strategy for DepS management, but it costly and difficult to scale up. Instead, dietary education cost-effective may be more conducive the promotion of strategy. Methods: A prospective, assessor-blinded, two-arm randomized controlled trial was designed determine effects 12-week on in cancer depression. Adult female depression receiving adjuvant...
Objectives: Cancer-related fatigue (CRF) is highly prevalent in patients with breast cancer, resulting undesirable outcomes and even reduced survival rates. This cross-sectional study investigated the relationship between dietary quality CRF potential role of gut microbiota (GM) this association. Methods: Dietary intake were evaluated 342 patients, 64 fecal samples collected for 16sRNA sequencing 106 plasma tryptophan (TRP) metabolite determination. Results: A total 149 (43.6%) experienced...
To explore the association between oxidative balance score (OBS) and cancer-related cognitive impairment (CRCI) in patients with lung cancer, as well stress biomarkers involved.
Circadian gene transcription is fundamental to metabolic physiology. Here we report that the nuclear receptor REV-ERBα, a repressive component of molecular clock, forms circadian condensates in nuclei mouse liver. These are dictated by an intrinsically disordered region (IDR) located protein’s hinge which specifically concentrates corepressor 1 (NCOR1) at genome. IDR deletion diminishes recruitment NCOR1 and disrupts rhythmic vivo. REV-ERBα high-order transcriptional hubs liver genome highly...
Abstract Combinatorial immunotherapy (CIT) has afforded patients with advanced HCC a potential for long-term survival. However, sustained responses are seen only in minority of patients. Thus, there is an unmet need precision modeling to differentiate responder vs. non-responders and uncover predictive biomarkers. Here, we establish mouse models mimic genetic alterations human by either overexpression MYC Tgfa (Myc OE ;Tgfa ) or combining activated b-catenin inactivated p53 (N90-CTNNB1...