A5048009054- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Cholesterol and Lipid Metabolism
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
University at Albany, State University of New York
2020-2021
University of Pennsylvania
2018
Significance Obesity has reached pandemic levels, prompting the need for novel therapeutics. The immune system been suggested to be critically linked metabolic health, leading prospect of immune-directed therapies. We report that obese fat tissue contains multiple distinct populations macrophages with unique distributions, transcriptomes, chromatin landscapes, and functions. These results provide a higher resolution cellular functional heterogeneity within adipose framework which develop new...
Many bacterial genes are regulated by RNA elements in their 5´ untranslated regions (UTRs). However, the full complement of these is not known even model bacterium Escherichia coli . Using complementary RNA-sequencing approaches, we detected large numbers 3´ ends UTRs and open reading frames (ORFs), suggesting extensive regulation premature transcription termination. We documented for multiple transcripts, including spermidine induction involving Rho translation an upstream ORF mRNA encoding...
Vascular aging has been documented as a vital process leading to arterial dysfunction and age-related cardiovascular cerebrovascular diseases. However, our understanding of the molecular underpinnings phenotypes in vascular system is incomplete. Here we performed bulk RNA sequencing young old mouse aortae elucidate age-associated changes transcriptome. Results showed that majority upregulated pathways aged relate immune response, including inflammation activation, apoptotic clearance,...
Abstract Many bacterial genes are regulated by RNA elements in their 5′ untranslated regions (UTRs). However, the full complement of these is not known even model bacterium Escherichia coli . Using complementary RNA-sequencing approaches, we detected large numbers 3′ ends UTRs and open reading frames (ORFs), suggesting extensive regulation premature transcription termination. We documented for multiple transcripts, including spermidine induction involving Rho translation an upstream ORF mRNA...