A5019165930- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Gastric Cancer Management and Outcomes
- TGF-β signaling in diseases
- RNA modifications and cancer
- Pleural and Pulmonary Diseases
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Medical Imaging Techniques and Applications
- Lymphatic System and Diseases
- Bone Tumor Diagnosis and Treatments
- Microbial Applications in Construction Materials
- Oral and gingival health research
- Macrophage Migration Inhibitory Factor
- Safety and Risk Management
- Phagocytosis and Immune Regulation
- Thermal Regulation in Medicine
- Protein Kinase Regulation and GTPase Signaling
- Ferroptosis and cancer prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Infrastructure Resilience and Vulnerability Analysis
- Internet Traffic Analysis and Secure E-voting
- Autophagy in Disease and Therapy
Fuzhou University
2025
Hubei University of Medicine
2020-2023
Albany Medical Center Hospital
2017-2023
Fujian Provincial Cancer Hospital
2023
Fujian Medical University
2023
Xiang Yang No.1 People's Hospital
2023
Peking University People's Hospital
2020-2022
Zhongshan Hospital
2021-2022
Fudan University
2020-2022
Peking University
2020-2022
Activation of vascular smooth muscle cell (VSMC) inflammation is vital to initiate disease. The role human-specific long noncoding RNAs in VSMC poorly understood.
Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy. Myocardin related transcription factor A (MRTFA, MKL1) multifaceted factor, regulating diverse biological processes. However, detailed understanding of the mechanistic role MKL1 in AAA has yet to be elucidated. In this study, we showed induced expression thoracic and abdominal aneurysmal tissues, respectively both mice humans. global knockout displayed reduced formation rupture compared wild-type mice....
Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), redox-regulated p38MAPK family member was negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated function VSMC-MAPK14 vivo injury-induced neointima hyperplasia and underlying mechanism using an inducible SMC-MAPK14 knockout mouse line (iSMC-MAPK14-/-). show MAPK14 expression activity were induced VSMCs after carotid artery ligation injury mice ex cultured human...
Tetraspanins (TSPANs) comprise a large family of 4-transmembrane domain proteins. The importance TSPANs in vascular smooth muscle cells (VSMCs) is unexplored. Given that TGF-β1 and myocardin (MYOCD) are potent activators for VSMC differentiation, we screened MYOCD/serum response factor (SRF)–regulated by using RNA-seq analyses RNA-arrays. TSPAN2 was found to be the only TSPAN gene induced MYOCD, reduced SRF deficiency VSMCs. We also highly expressed muscle–enriched tissues down-regulated...
Abstract Background Preventing breast cancer-related lymphedema (BCRL) by preserving upper lymphatic drainage is still controversial. Our study aimed to use the axillary reverse mapping (ARM) technique in patients who underwent surgery analyse correlation between postoperative residual ARM nodes and occurrence of lymphedema, select candidates at high risk developing oncologic safety nodes. Methods Patients undergoing sentinel lymph node biopsy (SLNB) or dissection (ALND) from October 2015...
Vascular aging has been documented as a vital process leading to arterial dysfunction and age-related cardiovascular cerebrovascular diseases. However, our understanding of the molecular underpinnings phenotypes in vascular system is incomplete. Here we performed bulk RNA sequencing young old mouse aortae elucidate age-associated changes transcriptome. Results showed that majority upregulated pathways aged relate immune response, including inflammation activation, apoptotic clearance,...
In F9 teratocarcinoma stem cells, retinoic acid induces a primitive endoderm-like phenotype and sharp decline in G alpha i-2, response mimicked by expression of RNA antisense to i-2 the absence this morphogen (D. C. Watkins, G. L. Johnson, Malbon. Science Wash. DC 258: 1373-1375, 1992). The role GS alpha/G axis cellular differentiation was explored. acid, cells stably expressing constitutively active mutant (G225T) progressed endoderm phenotype, as judged morphological markers, such tissue...
Morphogen-induced decline in Giα triggers F9 teratocarcinoma stem cells to progress primitive endoderm via activation of protein kinase C and mitogen-activated (Gao, P., Malbon, C. (1996) J. Biol. Chem. 271, 9002-9008). Constitutive expression Giα2 blocks, whereas Gsα provokes, progression endoderm, permitting identification the effectors response-utilizing chimera created between Gsα. N-terminal substitution with sequence create (1-54)/Gsα produced a that activated adenylylcyclase but...
The linkage between G and morphogen-induced promotion of F9 embryonic teratocarcinoma stem (F9 stem) cells to primitive endoderm was explored using probes the mitogen-activated protein (MAP) kinase network. decline in is shown trigger activation phospholipase C, thereby activating MAP kinase, cell progression endoderm. In absence retinoic acid, reduction-of-function mutants (G-deficient) display effects morphogen, i.e. Gain-of-function (expressing Q205L activating-mutation G) displayed no...
In order to circumvent Internet censorship, more and malicious users utilize Virtual Private Network (VPN) software penetrate firewall access restricted resources. It's important identify classify VPN traffic for network management security. this paper, 6 different kinds of are analyzed. Characterizing by Sample Entropy Fingerprint Payload Length Sequence (PLS) separately, we apply Machine Learning (ML) algorithms construct classifiers basing on these features. Comparing with Deep Packet...
The popularity of mobile dating applications has reconstructed how people initiate new romantic relationships. Photo attractiveness, the most prominent information provided in online context before social interactions, attracted considerable attention but reached inconsistent conclusions. By considering location, gender, and attractiveness difference between each dyad participants (hunter target) together, this study attempts to re-examine contingent impact physical initiating interactions....
Heinrich's law shows that the occurrence of a large number unsafe events will inevitably lead to heavy casualties. At present, more than 80% aviation accidents are related human factors, and study factors in incidents is conducive prevention accidents. There many organizations industry, an incident often involves organizations. Based on OHFAM model paper analyses typical security behavior, prerequisites for middle-level management, organization government regulatory details application event...
Bronchial asthma (BA) is a serious problem affecting the quality of life patients. Long noncoding RNAs (lncRNAs) are involved in BA. This study set out to investigate expressions PVT1/miR-423-5p serum BA patients and its clinical value on diagnosis evaluation. included same number (N = 100) with at remission (BA-R), exacerbation (BA-E), healthy controls. PVT1 level was increased BA-R BA-E patients, higher than miR-141-3p targeted PVT1. miR-423-5p downregulated negatively correlated Area...