A5103150101- Gut microbiota and health
- Tryptophan and brain disorders
- Ferroptosis and cancer prognosis
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Treatment of Major Depression
- Angiogenesis and VEGF in Cancer
- Neurotransmitter Receptor Influence on Behavior
- Rheumatoid Arthritis Research and Therapies
- Helicobacter pylori-related gastroenterology studies
- Machine Learning in Bioinformatics
- Mental Health Research Topics
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Stress Responses and Cortisol
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traditional Chinese Medicine Studies
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Parkinson's Disease Mechanisms and Treatments
- Gastrointestinal disorders and treatments
- Nuclear Receptors and Signaling
- Genomics and Rare Diseases
- Pediatric health and respiratory diseases
Lishui City People's Hospital
2020-2025
Tianjin Medical University
2023-2025
Tianjin Huanhu Hospital
2025
Xian Yang Central Hospital
2020-2024
Wenzhou Medical University
2023-2024
Peking University
2002-2023
Peking University People's Hospital
2023
Peking University International Hospital
2023
Yuhuangding Hospital
2016-2022
Lishui Central Hospital
2022
ABSTRACT Background Plasma protein has gained prominence in the non‐invasive predicting of lung cancer. We utilised Zeolite Zotero NaY‐based plasma proteomics to investigate its potential for multiple event predicting, including cancer diagnosis (task #1), lymph node metastasis detection #2) and tumour‒node‒metastasis (TNM) staging #3). Methods A total 4703 proteins were quantified from 241 participants based on a prospective cohort 2757 participants. An additional 46 external 735 used...
Mounting evidence indicates that alterations in the intestinal microbiota may be associated with neurological disorders such as multiple sclerosis (MS). MS is a putative autoimmune disease of central nervous system. However, it has not been determined whether and host immune status are altered Chinese patients stable MS. In our study, 22 33 healthy controls were enrolled for fecal analysis immunity evaluation. The microbial diversity composition, bacterial co-occurrence correlations,...
Depression in childhood negatively affects the growth and development, school performance, peer or family relationships of affected children, may even lead to suicide. Despite this, its etiology pathophysiology remain largely unknown. Increasing evidence supports that gut microbiota plays a vital role development depression. However, little is known about underlying mechanisms, as most clinical studies investigating link between depression have been undertaken adult cohorts. In present...
Schizophrenia (SZ) is a severe neuropsychiatric disorder with largely unknown etiology and pathogenesis. Mounting preclinical clinical evidence suggests that the gut microbiome vital player in SZ. However, microbiota characteristics its host response elderly SZ patients are still not well understood. A total of 161 samples was collected, including 90 from 71 healthy controls. We explored profiles targeting V3–V4 region 16S rRNA gene by MiSeq sequencing, to analyze their associations immune...
Our study aimed to evaluate the prognostic value of NT-proBNP in predicting adverse outcomes among patients with anterior circulation infarction (ACI) and posterior (PCI), specifically those without pre-existing cardiac comorbidities. This single-center, prospective observational enrolled acute ischemic stroke (AIS) within 7 days symptom onset. We elucidate predictive role levels determining AIS patients. Additionally, sought explore relationship between risk poor functional both ACI PCI...
Microglia-evoked neuroinflammation contributes to neurodegenerative diseases such as multiple sclerosis (MS). Metabolic reprogramming, including changes in polyunsaturated fatty acids (PUFAs), plays a critical role MS pathophysiology. Previous studies identified reduced plasma α-dimorphecolic acid (α-DIPA), linoleic derivative, patients. This study investigated the anti-inflammatory effects of α-DIPA on microglia and underlying pathways. Lipopolysaccharide (LPS)-induced BV-2 microglial...
Abstract Schizophrenia (SZ) is a complex psychiatric neurodevelopmental disorder with uncertain etiology and pathogenesis. Increasing evidence has recognized the key role of gut microbiota in SZ. However, few studies have investigated potential link between oral We studied tongue coating inflammatory profiles 118 elderly SZ patients 97 age-matched healthy controls using Illumina MiSeq sequencing multiplex immunoassays, respectively. Reduced α-diversity, along significant difference...
Psychiatric disorders are a class of complex characterized by brain dysfunction with varying degrees impairment in cognition, emotion, consciousness and behavior, which has become serious public health issue. The NGFR gene encodes the p75 neurotrophin receptor, regulates neuronal growth, survival plasticity, was reported to be associated depression, schizophrenia antidepressant efficacy human patient animal studies. In this study, we investigated its association major depression role...
Recent evidence suggests that lung microbiota can be recognized as one of the ecological determinants various respiratory diseases. However, alterations in and associated immunity these diseases remain unclear. To compare immune profiles common diseases, a total 78 patients were enrolled present study, including 21 with primary pulmonary tuberculosis (PTB), eight newly diagnosed cancer (LC), 49 community-acquired pneumonia (CAP). Bronchoalveolar lavage fluid (BALF) was collected for cytokine...
Papillary thyroid carcinoma (PTC) is the most common subtype of cancer. PTC typically curable with an excellent survival rate; however, some patients experience disease recurrence or death. This study aimed to discover potential key genes and signaling pathways PTC, which could provide new insights for lesions. Four GEO microarray datasets were integrated screen candidate involved in progression. A total 164 upregulated 168 downregulated differentially expressed (DEGs) screened. Gene...
The high prevalence of hepatitis B and C viruses (HBV HCV), paralleling the growing epidemic human immunodeficiency virus (HIV) Treponema pallidum (TP) infections in general population, poses a great threat to blood safety China. This study investigated serological markers for causative agents transfusion-transmissible (TTI), i.e. HBV, HCV, HIV TP, among volunteer donors five cities/regions Zhejiang Province, China.We whole apheresis donations collected at Blood Services Province between...
BACKGROUND ABCA2 has been genetically linked to Alzheimer's disease (AD) risk, but its mRNA expression and epigenetics in AD have not investigated. MATERIAL AND METHODS To explore the diagnosis value of AD, 2 datasets GES15222 GSE33000 containing profile brain cortex tissues GSE63063 (Cohort 1) 2) blood were downloaded from NCBI GEO database analyzed by receiver operating characteristic curve (ROC) analyses logistic regression. The co-expressed genes also GO annotation investigate potential...
Multiple sclerosis (MS) is an autoimmune disease that leads to the demyelination of nerve axons. An increasing number studies suggest patients with MS exhibit altered metabolic profiles, which might contribute course MS. However, alteration profiles in Chinese and their potential roles regulating immune system remain elusive. In this study, we performed a global untargeted metabolomics approach plasma samples from 22 MS-affected 21 healthy subjects. A total 42 differentially abundant...
Multiple sclerosis (MS) is an autoimmune disorder caused by chronic inflammatory reactions in the central nervous system. Currently, little known about changes of plasma proteomic profiles Chinese patients with MS (CpwMS) and its relationship altered multi-omics such as metabolomics gut microbiome, well potential molecular networks that underlie etiology MS. To uncover characteristics proteomics landscape interaction CpwMS, Plasma samples were collected from 22 CpwMS healthy controls (HCs)...
Oral microbial dysbiosis contributes to the development of schizophrenia (SZ). While numerous studies have investigated alterations in oral bacterial microbiota among SZ patients, investigations into fungal microbiota, another integral component are scarce. In this cross-sectional study, we enrolled 118 Chinese patients with and 97 age-matched healthy controls (HCs) evaluate from tongue coating samples using internal transcribed spacer 1 amplicon sequencing assess host immunity via multiplex...
Abstract Background Biallelic mutations in the MYORG gene were first identified as cause of recessively inherited primary familial brain calcification. Interestingly, some heterozygous carriers also exhibited calcifications. Objectives To further investigate role single development Methods A nation‐wide cohort Chinese calcification probands was enrolled from March 2016 through September 2019. Mutational analysis performed 435 who negative for other four known calcification–causative genes (...
Abstract Happiness and depression are interlinked both heritable, while personality, as an important predictor of them, shares the genetic basis with them. We conjecture that factors can affect depressive symptoms (DS) subjective well-being (SWB), personality traits play roles in mediating this process. In study, 878 Han Chinese college freshmen 384 patients major disorder (MDD) were included. SNPs genotyped using AGENA MassARRAY iPLEX technology we investigated MDD variant rs454214....
Zhuling Jisheng decoction is employed for the treatment of bladder urothelial cancer in clinical practice traditional Chinese medicine. However, there are few studies on its precise mechanism. For antibladder action decoction, a network pharmacological technique was used to design component/target/pathway molecular regulatory network. The TCMSP dataset identify chemical makeup which then analyzed and assessed oral bioavailability similarity. composition identified through database, it...